HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Complement C1q (C1q Complement)

A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Also Known As:
C1q Complement; Complement 1q; Complement Component 1q; C1q, Complement; Complement, C1q; Component 1q, Complement
Networked: 81 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Trendelenburg, Marten: 7 articles (10/2015 - 11/2005)
2. Lu, Jinhua: 3 articles (09/2015 - 08/2010)
3. Danner, Doris: 3 articles (04/2011 - 09/2008)
4. Bigler, Cornelia: 3 articles (04/2011 - 09/2009)
5. Schaller, Monica: 3 articles (04/2011 - 09/2009)
6. Yeo, Joo Guan: 2 articles (09/2015 - 05/2011)
7. Yolken, Robert H: 2 articles (05/2015 - 12/2012)
8. Severance, Emily G: 2 articles (05/2015 - 12/2012)
9. Petrek, Martin: 2 articles (01/2011 - 01/2011)
10. Khoyetsyan, Aren: 2 articles (01/2011 - 01/2011)

Related Diseases

1. Atherosclerosis
2. Lupus Nephritis
3. Schizophrenia (Dementia Praecox)
4. Peri-Implantitis
5. Type 2 Diabetes Mellitus (MODY)

Related Drugs and Biologics

1. Non-alcoholic Fatty Liver Disease
2. Antibodies
3. Autoantibodies
4. Immunoglobulin G (IgG)
5. Complement System Proteins (Complement)
6. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7. Antigen-Antibody Complex (Immune Complex)
8. Interleukins
9. Complement C3 (C3 Complement)
10. Collagen

Related Therapies and Procedures

1. Ligation