Estrogen Replacement Therapy

The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.

Also Known As:

Estrogen Progestin Combination Therapy; Estrogen Progestin Replacement Therapy; Estrogen Replacement; Replacement, Estrogen; Therapy, Estrogen Replacement; Estrogen Replacement Therapies; Estrogen Replacements; Hormone Replacement Therapy, Post Menopausal; Replacement Therapies, Estrogen; Replacements, Estrogen; Therapies, Estrogen Replacement; Hormone Replacement Therapy, Post-Menopausal; Postmenopausal Hormone Replacement Therapy; Replacement Therapy, Estrogen

Networked: 2033 relevant articles (143 outcomes, 348 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Hormone Replacement Therapy: 5377
    - Estrogen Replacement Therapy: 2033

Experts

1.	Herrington, David M: 16 articles (02/2016 - 03/2002)
2.	Shuid, Ahmad Nazrun: 8 articles (03/2015 - 01/2011)
3.	Misra, Madhusmita: 6 articles (01/2019 - 10/2011)
4.	Mohamed, Norazlina: 6 articles (12/2013 - 01/2011)
5.	Hodis, Howard N: 6 articles (06/2013 - 01/2003)
6.	Sohrabji, Farida: 5 articles (01/2020 - 06/2005)
7.	Li, Yan: 5 articles (02/2016 - 06/2003)
8.	Lichtenstein, Alice H: 5 articles (02/2016 - 09/2004)
9.	Mack, Wendy J: 5 articles (06/2013 - 01/2003)
10.	Ren, Jun: 5 articles (03/2012 - 06/2004)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 02/23/2000 - "Several reports from small clinical trials have suggested that estrogen replacement therapy may be useful for the treatment of Alzheimer disease (AD) in women. " 01/01/1998 - "Epidemiologic studies suggest protective effects against Alzheimer's disease from postmenopausal estrogen replacement and nonsteroidal anti-inflammatory drugs. " 10/01/1998 - "Collectively, these data demonstrate the ability for estrogen replacement to attenuate specific pharmacologically induced impairments in learning and retention and provide additional clues as to potential mechanisms by which estrogen replacement may help to reduce cognitive deficits associated with aging and Alzheimer's disease in postmenopausal women." 05/01/1998 - "Post-menopausal estrogen replacement therapy is associated with a reduction in the risk of Alzheimer's disease and has been reported to improve cognitive functioning in several small clinical trials. " 11/08/1996 - "Estrogen-replacement therapy has been associated with a reduced incidence of Alzheimer's disease (AD) and improved cognition in several small open clinical trials. "
2.	Osteoporosis 10/01/1999 - "Estrogen replacement therapy is increasingly used by perimenopausal and postmenopausal women for management of menopausal symptoms and for long-term protection against osteoporosis and arterial disease. " 03/01/1990 - "Although clinicians and policy groups have advocated estrogen replacement therapy and other clinical measures to prevent osteoporosis, few studies have assessed whether these measures are being adopted by physicians in practice. " 11/01/2020 - "Early initiation of estrogen replacement therapy (ERT) between 11-12 years of age, prompt titration to the adult dose after 2 years, and long-term follow-up to guarantee compliance with ERT, are the key points of osteoporosis prevention in women with TS." 01/01/2020 - "Two months after ovariectomy, osteoporosis occurred in the subchondral bone of the rats in the PMOP group, while fewer symptoms of osteoporosis occurred in the subchondral bone of the rats with estrogen replacement therapy. " 01/01/2019 - "We also found angiogenesis changed in early menopausal osteoporosis treated with estrogen replacement therapy. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 05/01/1996 - "These findings may help to explain the beneficial effects of estrogen replacement therapy in terms of protection from cardiovascular disease." 10/01/1999 - "Is physical activity as effective in reducing risk of cardiovascular disease as estrogen replacement therapy in postmenopausal women?" 06/01/1998 - "The aim of the present study was to evaluate the efficacy of transdermal estrogen replacement therapy in improving the risk profile of cardiovascular disease in postmenopausal women. " 03/01/2012 - "Although recent clinical trials have found an increased incidence of cardiovascular disease in women on estrogen replacement therapy, the underlying mechanism remains unclear. " 10/01/2006 - "Clinical trials failed to show a beneficial effect of postmenopausal hormone replacement therapy, whereas experimental studies in young animals reported a protective function of estrogen replacement in cardiovascular disease. "
4.	Postmenopausal Osteoporosis 06/01/1997 - "Replacement estrogen therapy is of proven efficacy for the prevention and treatment of postmenopausal bone loss. " 06/01/1991 - "Estrogen replacement therapy is effective in the prophylaxis of postmenopausal osteoporosis, and is the only therapy with well-proven antifracture efficacy. " 01/01/2001 - "Although estrogen replacement therapy (ERT) has been established as an effective treatment for postmenopausal bone loss, the clinical features which predict the effects of ERT have not been well investigated in Japanese postmenopausal women. " 02/01/1995 - "Estrogen replacement therapy is effective in the prevention of postmenopausal osteoporosis, and a direct action of 17-beta-estradiol (17 beta E2) on osteoblastic and osteoclastic cells has been demonstrated. " 04/01/1996 - "Estrogen replacement is known to manifest bone protective effects in the treatment of postmenopausal osteoporosis. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Evidence from the randomized trial shows a significant reduction in both incidence of and mortality from breast cancer in women who took estrogen replacement therapy; this message needs to be presented clearly and robustly so that it can help women with decision making when considering HRT for menopause." 09/28/2001 - "Because a categorical refusal of estrogen replacement therapy (ERT) from postmenopausal patients with a history of breast cancer is not based on any research evidence and may be more harmful than beneficial, we evaluated the safety and efficacy of ERT in these women. " 12/01/2018 - "Safe usage of vaginal estrogen replacement therapy in breast cancer patients has not been studied within randomised clinical trials of long duration; the guidelines below reflect a clinical consensus." 01/01/2016 - "Risk-modifying effects of premature ovarian insufficiency and estrogen-progestin replacement therapy on radiation-induced breast cancer require further study." 01/01/2016 - "Nonetheless, studies have suggested that estrogen replacement therapy is positively correlated to increased risk of breast cancer. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Progestins (Progestagens)
3.	Lipids
4.	Progesterone
5.	Estradiol (Delestrogen)
6.	Glucose (Dextrose)
7.	Medroxyprogesterone Acetate (Depo-Provera)
8.	Estrogen Receptors
9.	Calcitonin (Calcitonin, Eel)
10.	Lipoproteins (Lipoprotein)

Related Therapies and Procedures

1.	Therapeutics
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Ovariectomy (Oophorectomy)
4.	Secondary Prevention
5.	Aftercare (After-Treatment)