Thrombolytic Therapy

Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.

Also Known As:

Therapeutic Thrombolysis; Therapy, Fibrinolytic; Therapy, Thrombolytic; Fibrinolytic Therapies; Therapeutic Thrombolyses; Therapies, Fibrinolytic; Therapies, Thrombolytic; Thrombolyses, Therapeutic; Thrombolytic Therapies; Fibrinolytic Therapy; Thrombolysis, Therapeutic

Networked: 8675 relevant articles (705 outcomes, 1121 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Thrombolytic Therapy: 8675
    - Hirudin Therapy: 7

Experts

1.	Gibson, C Michael: 32 articles (11/2012 - 10/2002)
2.	Cannon, Christopher P: 27 articles (08/2009 - 10/2002)
3.	Antman, Elliott M: 25 articles (09/2010 - 10/2002)
4.	Schwamm, Lee H: 23 articles (01/2022 - 04/2002)
5.	Murphy, Sabina A: 23 articles (09/2010 - 10/2002)
6.	Saver, Jeffrey L: 22 articles (01/2022 - 01/2002)
7.	White, Harvey D: 22 articles (01/2022 - 01/2000)
8.	Granger, Christopher B: 21 articles (01/2022 - 09/2002)
9.	Braunwald, Eugene: 21 articles (01/2021 - 10/2002)
10.	Özkan, Mehmet: 20 articles (01/2022 - 02/2013)

Related Diseases

1.	Myocardial Infarction 01/01/2014 - "Reperfusion by means of percutaneous coronary intervention or thrombolytic therapy is the most effective treatment for acute myocardial infarction, markedly reducing mortality and morbidity. " 02/01/2008 - "Although primary coronary angioplasty seems to be the best treatment in acute myocardial infarction (MI), thrombolytic therapy still remains the most common reperfusion strategy particularly in smaller centers. " 05/25/2005 - "This article examines thrombolytic therapy, the first-line treatment for patients presenting with acute myocardial infarction in most UK hospitals. " 06/01/1996 - "These observational data, if replicated, suggest that in patients with acute myocardial infarction, thrombolytic therapy may be most effective in current smokers, whereas nonsmokers and ex-smokers may require other management strategies, such as emergency percutaneous transluminal coronary angioplasty." 12/01/1994 - "Thrombolytic therapy has been proven to be highly effective and safe in patients presenting with acute myocardial infarction. "
2.	Ischemic Stroke 12/01/2010 - "Only the latter has been proven to be effective in larger randomized trials and is a Class 1/Level A recommendation in national or international guidelines.(1) This review summarizes the evidence for thrombolytic therapy of acute ischemic stroke with emphasis on progress regarding the approved intravenous treatment. " 01/01/2016 - "Systemic thrombolytic therapy (STLT) is an available method of treatment of ischemic stroke (II) with proven efficacy. " 07/01/2015 - "Thrombolytic therapy has been proven to be effective in acute ischemic stroke treatment and shown to improve long-term functional outcomes. " 09/01/2009 - "Thrombolytic therapy has been proven to be beneficial in selected patients with ischaemic strokes. " 12/01/2021 - "Thrombolytic therapy has been shown to be beneficial in acute ischemic stroke. "
3.	Stroke (Strokes) 10/01/2014 - "Ample evidence has shown that patients presenting early and receiving intravenous thrombolytic therapy have the best chance for significant improvement in functional outcome, particularly if they are transported to specialized stroke centers. " 07/01/2014 - "Extending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND), a multicentre randomised controlled trial testing the efficacy of thrombolytic therapy in patients with clinically significant ischaemic penumbra between 4.5 to 9 hours after stroke onset, was used as a model to evaluate inclusion and exclusion criteria for late thrombolysis trials. " 04/01/2019 - "The outcome of stroke patients can be improved by a rapid initiation of thrombolytic therapy. " 06/05/2018 - "CONCLUSIONS MPV and CRP values were significantly associated with improvement in the NIH Stroke Scale and MRS scores in AIS when patients were treated with IV thrombolytic therapy within 4.5 hours of the onset of symptoms." 01/01/2012 - "In patients with stroke attributable to ICA occlusion, thrombolytic therapy results in a significant reduction in the proportion of patients dependent in activities of daily living. "
4.	Thrombosis (Thrombus) 05/01/2019 - "From a clinical perspective the ability to accurately assess the age and composition of thrombus is highly desirable given that anticoagulation and, in particular, fibrinolytic therapies are more effective in treating acute rather than chronic thrombosis. " 09/01/2016 - "However, in such giant thrombosis cases as this one, it is considered that thrombolytic therapy is ineffective and that immediate surgical resection is the best choice of treatment. " 03/01/2013 - "Thrombolytic therapy has been shown to be effective in most patients, resulting in complete resolution of the massive thrombus and clinical improvement. " 09/16/2008 - "The optimal management of the right heart thromboemboli remains unclear, but thrombolytic therapy with rt-PA appears to be rapidly effective in most patients resulting with complete resolution of the thrombus and improvement of pulmonary perfusion. " 01/01/2005 - "Consensus on optimal treatment continues to be hampered by a lack of randomized trials, but recent studies demonstrate the efficacy of thrombolytic therapy in acute thrombosis, and the apparent safety and benefit of anticoagulation in patients with chronic portal vein thrombosis."
5.	Infarction (Infarctions) 11/01/1997 - "Conservative intra-arterial thrombolytic therapy is considered to be the most effective treatment for renal infarction." 02/15/1993 - "Consequently, in this series, primary coronary angioplasty proved safe and highly effective in rapidly restoring sustained infarct-vessel patency during AMI, and led to a greater improvement in early and late outcomes than that reported in the literature for medically treated subjects in this high-risk subset for which thrombolytic therapy is contraindicated." 12/01/1986 - "In the long term, improved survival and enhanced quality of life are most evident after thrombolytic therapy in patients with larger anterior wall infarction, and less pronounced in patients with smaller inferior wall infarction." 01/01/1998 - "The levels of these inhibitors at the time of infarction may be important in the efficacy of thrombolytic therapy." 05/01/2000 - "(4-12) Several of these studies have found modest but statistically significant benefits in short-term mortality, reinfarction rates, infarct size, and/or complication rates.(4-8) Other studies failed to confirm these benefits and found the 2 therapies to be of equal value.(9-12) Emergency physicians who practice in centers that offer primary angioplasty are frequently faced with the conundrum of whether to activate the emergency cardiac catheterization team or give fibrinolytic therapy in the ED. "

Related Drugs and Biologics

1.	Tissue Plasminogen Activator (Alteplase)
2.	Streptokinase
3.	Urokinase-Type Plasminogen Activator (Urokinase)
4.	Fibrinolytic Agents (Antithrombotic Agents)
5.	Heparin (Liquaemin)
6.	Anticoagulants
7.	Aspirin (Acetylsalicylic Acid)
8.	Plasminogen Activators (Plasminogen Activator)
9.	Clopidogrel (Plavix)
10.	Fibrin

Related Therapies and Procedures

1.	Therapeutics
2.	Percutaneous Coronary Intervention
3.	Catheters
4.	Contraindications
5.	Thrombectomy