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Thrombolytic Therapy

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Use of infusions of fibrinolytic agents to destroy or dissolve thrombi in blood vessels or bypass grafts.

Also Known As:

Therapeutic Thrombolysis; Therapy, Fibrinolytic; Therapy, Thrombolytic; Fibrinolytic Therapies; Therapeutic Thrombolyses; Therapies, Fibrinolytic; Therapies, Thrombolytic; Thrombolyses, Therapeutic; Thrombolytic Therapies; Fibrinolytic Therapy; Thrombolysis, Therapeutic

Networked: 5551 relevant articles (423 outcomes, 744 trials/studies) for this Therapy, Comments

Relationship Network

Therapy Context: Research Results

Therapeutics: 6904
- Drug Therapy: 126775
  - Thrombolytic Therapy: 5551
    - Hirudin Therapy: 7

Experts

1.	Gibson, C Michael: 26 articles (08/2009 - 10/2002)
2.	Cannon, Christopher P: 24 articles (08/2009 - 10/2002)
3.	Antman, Elliott M: 23 articles (01/2009 - 10/2002)
4.	Murphy, Sabina A: 21 articles (01/2009 - 10/2002)
5.	Braunwald, Eugene: 19 articles (01/2009 - 10/2002)
6.	Sabatine, Marc S: 15 articles (08/2009 - 01/2005)
7.	Giugliano, Robert P: 14 articles (01/2009 - 01/2003)
8.	Krumholz, Harlan M: 13 articles (12/2009 - 09/2002)
9.	White, Harvey D: 12 articles (06/2010 - 07/2002)
10.	Chopp, Michael: 12 articles (11/2009 - 06/2003)

Related Diseases

1.	Myocardial Infarction 02/01/2008 - "BACKGROUND: Although primary coronary angioplasty seems to be the best treatment in acute myocardial infarction (MI), thrombolytic therapy still remains the most common reperfusion strategy particularly in smaller centers. " 05/25/2005 - "This article examines thrombolytic therapy, the first-line treatment for patients presenting with acute myocardial infarction in most UK hospitals. " 06/01/1996 - "CONCLUSIONS: These observational data, if replicated, suggest that in patients with acute myocardial infarction, thrombolytic therapy may be most effective in current smokers, whereas nonsmokers and ex-smokers may require other management strategies, such as emergency percutaneous transluminal coronary angioplasty." 12/01/1994 - "Thrombolytic therapy has been proven to be highly effective and safe in patients presenting with acute myocardial infarction. " 05/01/1996 - "Multiple clinical trials have proven that thrombolytic therapy is an effective treatment for acute myocardial infarction. " Order ALL the reference details at left...
2.	Stroke (Strokes) 09/01/2009 - "Thrombolytic therapy has been proven to be beneficial in selected patients with ischaemic strokes. " 01/01/1993 - "CONCLUSIONS: Emergency cerebral angiography, which can be carried out relatively safely, adds important information about the nature and extent of the arterial occlusions, and the recanalization efficacy of fibrinolytic therapy for patients with acute stroke. " 05/01/2008 - "BACKGROUND AND PURPOSE: Results of our recent pilot clinical trial suggest that the efficacy of thrombolytic therapy in acute ischemic stroke may be enhanced by the coadministration of high-dose albumin. " 09/01/2003 - "RESULTS: Helicopter transport of acute stroke patients to tertiary care centers for thrombolytic therapy costs $35,000 per additional good outcome and $3,700 per QALY for the reference case. " 01/01/2003 - "For patients treated within three hours of stroke, thrombolytic therapy appeared more effective in reducing death or dependency (OR 0.66, 95% CI 0.53 to 0.83) with no statistically significant adverse effect on death (OR 1.13, 95% CI 0.86 to 1.48). " Order ALL the reference details at left...
3.	Thrombosis (Thrombus) 09/16/2008 - "The optimal management of the right heart thromboemboli remains unclear, but thrombolytic therapy with rt-PA appears to be rapidly effective in most patients resulting with complete resolution of the thrombus and improvement of pulmonary perfusion. " 01/01/2005 - "Consensus on optimal treatment continues to be hampered by a lack of randomized trials, but recent studies demonstrate the efficacy of thrombolytic therapy in acute thrombosis, and the apparent safety and benefit of anticoagulation in patients with chronic portal vein thrombosis." 01/01/1994 - "The paper reports a case of a positive response to fibrinolytic therapy with complete lysis of the thrombus in the left internal carotid artery (ICA) and significant reduction of the baseline neurological deficiency. " 04/01/2002 - "We report the successful management of acute portal vein thrombosis with percutaneous transphepatic thrombolytic therapy. " 02/01/1994 - "Local thrombolytic therapy may be beneficial for other patients with rapid neurologic deterioration caused by extensive thrombosis of superficial and deep venous structures." Order ALL the reference details at left...
4.	Pulmonary Embolism 12/01/2009 - "Acute massive pulmonary embolism with hemodynamic compromise treated successfully with thrombolytic therapy." 09/01/1998 - "This case suggests that delayed thrombolytic therapy in patients with massive pulmonary embolism can still be beneficial in selected cases, even if given more than 2 weeks after symptom onset." 06/01/1996 - "We found a significant ABD-assisted right ventricular hypokinetic regression after thrombolytic therapy in acute pulmonary embolism but could not demonstrate a linear relation between improvement in early right ventricular function and angiography." 06/01/1989 - "Many investigators have reported about beneficial results with thrombolytic therapy in patients with acute pulmonary embolism. " 04/15/1992 - "OBJECTIVES: To determine whether thrombolytic therapy reduces the rate of death or complications in patients with acute pulmonary embolism and whether a particular thrombolytic regimen is more effective than others. " Order ALL the reference details at left...
5.	Hemorrhage 12/19/1996 - "Despite the fact that each of the third-generation drugs has shown considerable potential with regard to improving the efficacy of thrombolytic therapy, the risk of intracranial bleeding remains problematic and will need to be assessed in large, randomized trials." 09/01/1994 - "Although safe and effective, thrombolytic therapy is relatively contraindicated within 10 days of major surgery due to the risk of bleeding. " 11/19/1988 - "Our experience confirms the reduced incidence of allergic side effects (3.5%), major bleeding (0.3%) and minor bleeding (2.9%) during or after thrombolytic therapy." 12/01/2003 - "However, primary percutaneous coronary intervention (PCI) is associated with improved outcomes and less bleeding complications compared with fibrinolytic therapy, but it is not widely available. " 12/01/1993 - "All 3 trials have shown that immediate PTCA does not affect positively, but can worsen, the outcome of thrombolytic therapy since it increases mortality and bleeding complication with no improvement in reocclusion rate. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Tissue Plasminogen Activator (Alteplase)
2.	Streptokinase
3.	Urokinase-Type Plasminogen Activator (Urokinase)
4.	Heparin (Liquaemin)
5.	Aspirin (Acetylsalicylic Acid)
6.	Fibrinolytic Agents (Antithrombotic Agents)
7.	glucuronyl glucosamine glycan sulfate (Vessel)
8.	Fibrin
9.	Plasminogen Activators (Plasminogen Activator)
10.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)

Related Therapies and Procedures

1.	Angioplasty (Angioplasties)
2.	Percutaneous Coronary Transluminal Angioplasty (PTCA)
3.	Cardiopulmonary Resuscitation (CPR)
4.	Transplants (Transplant)
5.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)

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