|3.||Diabetic Retinopathy (Retinopathy, Diabetic)
|4.||Sarcoidosis (Schaumann Disease)
|1.||Campochiaro, Peter A: 22 articles (08/2014 - 03/2002)|
|2.||Kim, Jeong Hun: 15 articles (02/2015 - 11/2007)|
|3.||Kim, Jin Hyoung: 15 articles (02/2015 - 11/2007)|
|4.||Smith, Lois E H: 13 articles (09/2015 - 07/2003)|
|5.||Shen, Jikui: 13 articles (08/2014 - 01/2004)|
|6.||Chen, Jing: 12 articles (09/2015 - 06/2007)|
|7.||Grant, Maria B: 12 articles (09/2015 - 06/2002)|
|8.||Sorenson, Christine M: 11 articles (09/2015 - 12/2003)|
|9.||Sheibani, Nader: 11 articles (09/2015 - 12/2003)|
|10.||Penn, John S: 11 articles (10/2014 - 12/2003)|
04/01/2006 - "Finally, a significant reduction in the severity of abnormal retinal neovascularization was observed in the eyes treated with soluble EphA2-Fc receptors, yet the normal total retinal vascular area was not significantly changed. "
06/01/2003 - "The uPAR(-/-) mouse demonstrated normal retinal vascular development; however, the absence of functional uPAR resulted in a significant reduction in the extent of retinal neovascularization. "
01/01/2012 - "These results demonstrate long-term efficacy of AAV-mediated PEDF overexpression in counteracting retinal neovascularization in a relevant animal model, and provides evidence towards the use of this strategy to treat angiogenesis in DR and other chronic proliferative retinal disorders."
03/01/2013 - "The purpose of this study was to characterize diabetic retinal neovascularization (NV) and accompanying retinal and vitreal morphologic changes using high-resolution spectral domain optical coherence tomography. "
01/01/2010 - "This observation may provide a basis for study of relationship between EPCs and retinal neovascularization, as well as further clinical application of EPCs in ischemic retinal lesions."
|2.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/01/2010 - "Although antiangiogenic therapies using anti-VEGF drugs are effective in treating retinal neovascularization, they show a transient efficacy and cause general adverse effects. "
06/01/1999 - "Previous studies have demonstrated partial inhibition of retinal neovascularization in animal models using antagonists of vascular endothelial growth factor or other signaling molecules implicated in the angiogenesis cascade. "
11/07/1995 - "In this study, we evaluated whether in vivo inhibition of VEGF action could suppress retinal neovascularization in a murine model of ischemic retinopathy. "
11/01/2015 - "It is known that VEGF causes a breakdown of the blood‑retinal barrier (BRB) and retinal neovascularization; however, how AGEs affect the retina has largely remained elusive. "
07/01/2015 - "Expression of COX-2 correlated positively with VEGF in retinal neovascularization. "
01/01/2014 - "Thus, the object of the present study is to examine the mechanism of action and efficacy of SDT on retinal neovascularization in oxygen-induced ischemic retinopathy (OIR) mice. "
12/01/2001 - "In this study, efficacy of AdoR antagonist administration in reducing retinal neovascularization was examined in a mouse pup model of oxygen-induced retinopathy. "
06/01/2014 - "The aim of this study was to determine whether PGC-1α is involved in the transcriptional regulation of retinal neovascularization in oxygen-induced retinopathy (OIR). "
03/15/2013 - "In the present study we show that haploinsufficiency of endoglin results in attenuation of retinal neovascularization during oxygen-induced ischemic retinopathy. "
01/01/2012 - "The goal of our study was to investigate whether 15-LOX-1 plays a role in inhibiting retinal neovascularization (RNV) in a mouse model of oxygen-induced retinopathy (OIR) and the underlying mechanism. "
10/01/2004 - "Nevertheless, the retinas of the RTP801-knockout mice in an ROP model showed a significant reduction in retinal neovascularization (P < 0.0001) and in the number of apoptotic cells in the inner nuclear layer (P < 0.0001). "
12/01/2015 - "Retinal neovascularization (RNV) is a characteristic pathological finding of retinopathy of prematurity (ROP). "
02/20/2015 - "Our results suggest that treatment with antioxidant drugs at early hyperoxic phase of ROP even before the appearance of retinal neovascularization may be more effective than their application to ROP at late phase, which may abolish the deleterious factors that contribute to retinal neovascularization and promote retinal blood vessels to develop healthily. "
09/01/2013 - "These data suggest that KH902 could serve as an innovative pharmaceutical agent to prevent retinal neovascularization (NV) and as a strategy for the treatment of ROP."
03/01/2013 - "The apelin/APJ system may be involved in the development of retinal neovascularization of ROP. "
|5.||Small Interfering RNA (siRNA)IBA
03/01/2011 - "[Experimental study of Twist siRNA to inhibit the formation of retinal neovascularization in mice]."
06/01/2014 - "Retinal neovascularization was inhibited by PGC-1α siRNA. "
06/01/2014 - "Suppression of retinal neovascularization by small interfering RNA targeting PGC-1α."
11/02/2012 - "Moreover, intravitreal administration of siRNA targeting ORP150 significantly reduced the retinal neovascularization in OIR. "
03/01/2011 - "PRR siRNA could obviously reduce PRR expression, inhibit ERK1/2 signal transduction passageway activation, and diminish retinal neovascularization."
01/01/2012 - "When using traditional laser settings, PRP performed with the PASCAL is less effective than that performed with traditional argon laser in effecting lasting regression of retinal neovascularization in the setting of previously untreated high-risk PDR. "
01/01/2010 - "In our case, bilateral preretinal, intraretinal, and intravascular diffuse oxalate crystals were detected, and argon laser photocoagulation treatments were needed for choroidal and retinal neovascularization. "
07/01/1989 - "20 cases (22 eyes) of retinal neovascularization (RNV) secondary to branch vein occlusion were treated with argon laser photocoagulation. "
07/01/1989 - "[Treatment of retinal neovascularization secondary to branch vein occlusion with argon laser photocoagulation]."
01/01/1973 - "Argon laser photocoagulation of diabetic retinal neovascularization (a five-year appraisal)."
|7.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/01/2009 - "While it is well established that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various cell types, the role of TRAIL in regulation of retinal neovascularization (NV) has not been described. "
01/01/2002 - "Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization."
05/01/2004 - "The results indicate that TNF-alpha is produced by activated macrophages/microglia and may participate in retinal neovascularization during post-ischemic inflammation through the induction of potent angiogenic factors in an autocrine or paracrine manner."
07/01/2011 - "The objective of the present study is to investigate the expression and activation of gelatinase associated with the retinal neovascularization in ED and the relation between the levels of gelatinase and the cytokine tumor necrosis factor-α, known to upregulate matrix metalloproteinase (MMP) expression on various cells. "
05/01/2004 - "We have extended these studies, and investigated whether TNF-alpha is localized in macrophages/microglia in the mouse model of retinal neovascularization, and whether TNF-alpha can induce angiogenic factors in retinal glial cells. "
12/01/2003 - "To study the putative role of endogenous matrix metalloproteinases (MMPs) in retinal neovascularization, an established mouse model was used to compare the retinal neovascularization observed in wild-type mice with that in mice without the MMP-2 or -9 genes. "
01/01/2001 - "To examine the expression of matrix metalloproteinases (MMPs) and their inhibitors during the development of retinal neovascularization (NV) in a mouse model. "
04/01/1999 - "Systemic inhibition of MMPs may have therapeutic potential in preventing retinopathy associated with retinal neovascularization. "
01/01/2002 - "The present study examines the potential role of tumor necrosis factor (TNF)-alpha as a regulator of MMPs in the retinal neovascularization process. "
12/01/2006 - "In retinas of rats with oxygen-induced neovascularization, the expression of LRP-1 and alpha2M was increased along with an enhanced activity of MMPs, suggesting that LRP-1 expression may play a role in modulating retinal neovascularization by regulating proteolytic activity."
11/01/2006 - "Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization."
03/01/2009 - "Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis."
04/01/2011 - "In clinical settings, inhibitors of Raf kinase have shown promising results in cancer treatment, and Raf kinase antisense oligonucleotides, iCo 007, is now in Phase II trial for macular edema, a chronic ocular disease associated with retinal neovascularization. "
07/15/2004 - "Local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice."
10/01/2008 - "To explore a novel strategy for balancing retinal neovascularization by assessing the role activin-like kinase receptor 1 (ALK1) plays in neovascularization in vascular endothelial growth factor (VEGF)-stimulated human retinal capillary endothelial cells (HRCECs). "
|10.||Messenger RNA (mRNA)IBA
11/01/2009 - "Endotatin can inhibit the expression of Tubulinbeta mRNA in retinal neovascularization, this may be correlated with the inhibitive characteristics of ES on neovascularization."
01/01/2004 - "The role of Y2-receptor in hyperoxemia-induced retinal neovascularization was investigated in Y2-receptor knockout mice (Y2-/-) and in rats administered Y2-receptor mRNA antisense oligonucleotide. "
02/01/1999 - "In a murine model of retinal neovascularization, thrombospondin-1 mRNA was increased from postnatal day 13 (P13), with a threefold peak response observed on P15, corresponding to the time of development of retinal neovascularization. "
11/01/2009 - "Quantitativereal-time PCR results indicated that, the expression of Tubulinbeta mRNA in retica was up-regulated in the process of retinal neovascularization induced by hyperoxia, and down-regulated by the treatment of ES. "
03/01/2009 - "Inhibiting EPO mRNA expression with siRNA is effective in suppressing retinal neovascularization, suggesting EPO siRNA is a potentially useful pharmaceutical intervention for treating proliferative retinopathy."
05/01/1994 - "Finally, the treatments for retinal neovascularization, including cryopexy and local and panretinal photocoagulation are reviewed, and techniques and possible mechanisms of the beneficial results of treatment are described."
01/01/2014 - "By 4 years after presentation, retinal neovascularization developed that was successfully treated with photocoagulation. "
01/01/2011 - "On the other hand, panretinal photocoagulation was associated with reduced risk of retinal neovascularization (OR=0.983; P=0.000). "
07/01/2005 - "Thereafter, retinal neovascularization in the right eye developed in 6 months to form a loop-shaped vascular network in the vitreous cavity despite panretinal photocoagulation. "
02/01/2001 - "It has been shown that scatter photocoagulation induces regression of retinal neovascularization, but the mechanism for this effect is not completely understood. "
04/01/2003 - "Laser to nonperfused retina caused some regression of retinal neovascularization. "
10/01/1999 - "The patient was treated with peripheral laser treatment to the ischemic retina with resultant regression of peripheral retinal neovascularization. "
01/01/2015 - "Patients were divided into two groups: group 1 included patients who received only IVR treatment; and group 2 was subdivided into group 2A - including patients with IVR as initial treatment and complementary laser photocoagulation if retinal neovascularization or plus disease did not regress, and group 2B - including patients with initial laser photocoagulation and IVR as rescue therapy. "
10/01/2011 - "Retinal neovascularization in the right eye was treated with laser photocoagulation. "
07/01/2008 - "Four months later, bilateral panretinal laser photocoagulation was performed due to retinal neovascularization. "
08/01/2005 - "This study was performed to determine the feasibility and efficacy of pars plana vitrectomy surgery using two (rather than three or four)-port access for treatment of diabetic patients with nonclearing vitreous haemorrhage due to retinal neovascularization. "
11/24/2015 - "Secondary outcomes included visual acuity area under the curve, peripheral visual field loss, vitrectomy, DME development, and retinal neovascularization. "
08/01/2005 - "Two-port pars plana vitrectomy (with endolaser treatment and membrane delamination if necessary) was performed in a prospective series of 12 consecutive diabetic patients with nonclearing vitreous haemorrhage due to retinal neovascularization. "
03/01/2005 - "Vitrectomy surgery was performed, and choroidal and retinal neovascularization was discovered. "
09/01/1981 - "We have found a good correlation between the presence of progressive retinal neovascularization in an eye and the ability of vitreous cavity fluid from that eye (obtained at the time of vitrectomy) to stimulate vascular endothelial cell migration in vitro."
08/01/2012 - "Intravitreal injection of this mutant caused a significant reduction in vascular obliteration and retinal neovascularization vs. saline injection in the OIR model. "
01/01/2011 - "The effect of unc5b on retinal neovascularization was evaluated by intravitreal injection of unc5b-FC in mice with OIR. "
07/01/2009 - "Intravitreal injection of anti-Cyr61 antibody significantly inhibited retinal neovascularization in the mouse OIR model. "
09/01/2007 - "A single intravitreal injection of 5-amino-2-NMS reduces significantly angioproliferative changes (blood vessel tufts, extra-retinal neovascularization, and blood vessel tortuosity) compared to the contralateral control eye (p=0.025). "
05/01/2003 - "Intravitreal injection of KBP inhibited retinal neovascularization in an OIR model. "
|5.||Laser Therapy (Surgery, Laser)
05/01/2005 - "Both laser therapy and vitrectomy improved visual acuity and induced regression of retinal neovascularization. "
03/01/2012 - "Intravenous sodium fluorescein 10% for laser ablation of subtle retinal neovascularization in FEVR."
05/01/1978 - "Since the complicating macular edema and retinal neovascularization respond, at least in part, to argon laser therapy in some other conditions, some investigators have begun to treat branch vein occlusions with this modality. "
07/01/1994 - "Since current argon laser therapy of retinal neovascularization causes immediate retinal damage, the ability to occlude choroidal vessels without inducing acute thermal damage holds promise for treating clinical pathologic conditions that feature abnormal neovascularization, such as age-related macular degeneration and diabetic retinopathy."
03/01/2014 - "There are several treatment modalities for branch retinal vein occlusion and specifically for its complications, such as macular edema, vitreous hemorrhage, retinal neovascularization, and retinal detachment, including anti-aggregative therapy and fibrinolysis, isovolemic hemodilution, vitrectomy with or without sheathotomy, peripheral scatter and macular grid retinal laser therapy, non-steroid agents, intravitreal steroids, and intravitreal anti-vascular endothelial growth factors (anti-VEGFs)."