|1.||Wek, Ronald C: 9 articles (05/2014 - 02/2004)|
|2.||Wek, R C: 5 articles (02/2006 - 02/2000)|
|3.||Narasimhan, Jana: 4 articles (06/2008 - 06/2004)|
|4.||McGrath, Barbara C: 3 articles (01/2007 - 02/2004)|
|5.||Cavener, Douglas R: 3 articles (01/2007 - 02/2004)|
|6.||Dey, Souvik: 2 articles (05/2014 - 05/2010)|
|7.||Wek, Sheree A: 2 articles (05/2014 - 02/2004)|
|8.||Baird, Thomas D: 2 articles (05/2014 - 04/2011)|
|9.||Storey, Kenneth B: 2 articles (02/2013 - 03/2002)|
|10.||Dever, Thomas E: 2 articles (11/2012 - 01/2009)|
11/10/1984 - "However, the dsRNA requirement for eIF-2 alpha phosphorylation in vitro was eliminated by prior infection of cells with reovirus Dearing strain virions but not with defective top component particles. "
10/01/2014 - "The alpha subunit of Eukaryotic Initiation Factor 2 (eIF2α) is a key translation regulator that plays an important role in cellular stress responses, which including virus infection. "
08/08/2013 - "PKR's pro-apoptotic role through eukaryotic initiation factor 2 α (eIF2α) phosphorylation is well established in the host defense against viral infection. "
01/01/2011 - "Remarkably, we now describe that poliovirus translation takes place at late times of infection when eIF2 is inactivated by phosphorylation. "
09/01/2010 - "Nonetheless, the dependency of IFN induction on IFN promoter stimulator 1 (IPS-1) as well as the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) suggest the cytoplasmic exposure of some viral dsRNA late in infection. "
12/01/1992 - "This conclusion is supported by biochemical studies showing that the truncated GLC7 allele increases the level of eIF-2 alpha phosphorylation in the gcn2-507 mutant to a level approaching that seen in wild-type cells under starvation conditions. "
05/23/2014 - "In response to amino acid starvation, GCN2 phosphorylation of eIF2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress. "
10/01/2010 - "The model predicts that the abundance of the eIF1-eIF3-eIF5 complex increases under amino acid starvation conditions, suggesting a possible auxiliary role for these factors in modulating translation initiation in addition to the known mechanisms involving eIF2. "
05/28/2010 - "Amino acid starvation activates the GAAC through Gcn2p phosphorylation of translation factor eIF2 and preferential translation of GCN4, a transcription activator. "
07/01/2005 - "Increased phosphorylation of eIF2 under amino acid starvation conditions leads to a corresponding increase in GCN4 mRNA translation. "
09/01/2004 - "At later times postinfection, VSV overcame a hypoxia-associated increase in alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha) phosphorylation and initial suppression of viral protein synthesis in hypoxic cells to produce large amounts of viral protein. "
03/01/2002 - "Western blotting of hepatopancreas samples from normoxic, 24 h anoxic, and 1 h aerobic recovered snails demonstrated that eIF-2alpha is substantially phosphorylated during anoxia exposure and dephosphorylated during normoxia and aerobic recovery, suggesting a decrease in translation initiation during anoxia exposure. "
02/27/2008 - "Protection of eIF-2alpha phosphorylation with systemically administered salubrinal throughout hypoxia/reoxygenation exposure prevented CHOP/GADD153 activation in susceptible motoneurons. "
12/01/2013 - "This study investigated whether or not the stress and hypoxia, which are the effects of radiation on normal vascular endothelium, leading to the release of HIF-1α, VEGF, eIF2, TIA-1, and TSP-1 were related and the possibility of them stimulating angiogenesis. Twenty-four male Swiss Albino mice were separated into 4 groups. "
02/01/2013 - "The phosphorylation state of protein kinase-like ER kinase (PERK) (a UPR-regulated kinase) and eukaryotic initiation factor 2 (eIF2α) increased by 1.43-2.50 fold in response to anoxia in turtle heart, kidney, and liver. "
|4.||Contagious Ecthyma (Orf)
04/01/2011 - "Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation."
03/14/2008 - "During non-stressed conditions, when eIF2 phosphorylation is low, ribosomes reinitiate translation at the next ORF, the inhibitory uORF2. "
04/01/2003 - "According to the known EST sequence, the 3'-terminal primer that matched the sequencing primer for the 5'-terminal in pTriplEx2 plasmid was designed and used to amplify the full-length open reading frame (ORF) sequence of the eIF2 alpha from the cDNA Library. "
04/01/2011 - "In this study, we show that eIF2 phosphorylation induces preferential translation of CHOP by a mechanism involving a single upstream ORF (uORF) located in the 5'-leader of the CHOP mRNA. "
11/01/2000 - "In contrast to Drosophila melanogaster, RT-PCR analysis in the two coleopteran and the lepidopteran species demonstrated the usage of a nonconserved splice donor site located within the 3' end of the SU(VAR)3-9 ORF, resulting in removal of the Su(var)3-9-specific stop codon from the mRNA and complete in-frame fusion of the SU(VAR)3-9 and eIF-2gamma ORFs. "
06/01/2004 - "Collectively, this study suggests that eIF2 kinase-mediated stress responses are conserved in Apicomplexa, and a novel family member exists that may control parasite-specific events, including the clinically relevant conversion into bradyzoite cysts."
06/13/2008 - "Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii."
|2.||Peptide Initiation Factors (Initiation Factor)
|3.||eIF-2 Kinase (eIF 2 Kinase)
|4.||Messenger RNA (mRNA)
|5.||Guanosine Triphosphate (GTP)
|6.||Staphylococcal Protein A (A, Protein)
|7.||Inhibitor of Apoptosis Proteins
|8.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|1.||Induced Heart Arrest (Cardioplegia)