Cochlear Diseases

Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).

Also Known As:

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Retinal Diseases
2.	Facioscapulohumeral Muscular Dystrophy
3.	Wounds and Injuries (Trauma)
4.	Ototoxicity

Experts

1.	Cristerna, Mayte Lizeth Padilla: 1 article (05/2022)
2.	Hernández, Lory Jhenifer Rochin: 1 article (05/2022)
3.	Jiménez-Acosta, Miguel A: 1 article (05/2022)
4.	Meraz-Ríos, Marco A: 1 article (05/2022)
5.	Al-Ubaidi, Muayyad R: 1 article (01/2021)
6.	Conley, Shannon M: 1 article (01/2021)
7.	Crane, Ryan: 1 article (01/2021)
8.	Naash, Muna I: 1 article (01/2021)
9.	Cilurzo, Francesco: 1 article (01/2018)
10.	Franzé, Silvia: 1 article (01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cochlear Diseases:

1.	Interleukin-1beta (Interleukin 1 beta)IBA 09/01/2002 - "Interleukin-1beta expression is a general cochlear response to trauma, whereas tumor necrosis factor-alpha expression in the infiltrated immunocompetent cells is the cytokine that induces amplification of the response that leads to cochlear disease."
2.	CytokinesIBA 09/01/2002 - "Interleukin-1beta expression is a general cochlear response to trauma, whereas tumor necrosis factor-alpha expression in the infiltrated immunocompetent cells is the cytokine that induces amplification of the response that leads to cochlear disease."
3.	Biomarkers (Surrogate Marker)IBA 10/11/2023 - "Neonatal treatment prevented the death of the sensory cochlear hair cells and rescued cochlear disease biomarkers as demonstrated by RNAseq and physiological measurements of auditory function. "
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/01/2002 - "Interleukin-1beta expression is a general cochlear response to trauma, whereas tumor necrosis factor-alpha expression in the infiltrated immunocompetent cells is the cytokine that induces amplification of the response that leads to cochlear disease."
5.	SteroidsIBA 01/01/2018 - "In clinical practice, the current pharmacological approaches to treat cochlear diseases are based on the almost exclusive use of systemic steroids. "
6.	Retinaldehyde (Retinal)IBA 10/01/1999 - "Yet remarkably, the nature of the gene product(s) of the affected proximal gene(s), as well as of the molecular pathogenesis of facioscapulohumeral muscular dystrophy muscle, retinal and cochlear disease, is completely unknown. "
7.	Indicators and Reagents (Reagents)IBA 01/01/1978 - "It is confirmed that the main indicator of retrocochlear versus cochlear disease is the interaural latency difference of the Jewett5 wave, the IT5. "
8.	Cisplatin (Platino)FDA LinkGeneric 01/01/2016 - "While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little is known about the function of C1P in cochlear diseases. "
9.	CeramidesIBA 01/01/2016 - "While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little is known about the function of C1P in cochlear diseases. "

Therapies and Procedures

1.	Therapeutics 03/01/2012 - "EP4 might therefore be an effective target for cochlear disease therapeutics." 01/01/2021 - "Recent exciting advances in gene therapy have shown promise for the clinical treatment of inherited retinal diseases, and while clinical gene therapies for cochlear disease are not yet available, research in the last several years has resulted in significant advancement in preclinical development for gene delivery to the cochlea. "
2.	Hearing Aids (Hearing Aid) 02/01/1994 - "This article will describe a clinical procedure using simultaneous pure-tone masking to improve upon the localization of cochlear disease, particularly for low-frequency hearing losses, and a model for using the Articulation Index (AI) to develop prognoses for hearing aid performance in these cases, which can then be tested. "