|3.||Encephalitis (Encephalitis, Rasmussen)
|1.||Walochnik, Julia: 7 articles (01/2015 - 03/2002)|
|2.||Alizadeh, Hassan: 7 articles (06/2014 - 11/2003)|
|3.||Bourcier, T: 5 articles (03/2015 - 11/2006)|
|4.||Alizadeh, H: 5 articles (12/2006 - 01/2000)|
|5.||Kowalski, Regis P: 4 articles (11/2015 - 10/2008)|
|6.||Sutphin, John E: 4 articles (01/2015 - 02/2002)|
|7.||Khan, Naveed Ahmed: 4 articles (01/2014 - 05/2007)|
|8.||Oikawa, Yosaburo: 4 articles (07/2013 - 11/2003)|
|9.||Tu, Elmer Y: 4 articles (12/2011 - 12/2006)|
|10.||Neelam, Sudha: 4 articles (01/2009 - 11/2003)|
02/01/2005 - "This assay has been optimized for determination of drug efficacy against two potentially pathogenic species, Acanthamoeba castellanii and Acanthamoeba polyphaga, and has been validated by comparison of their relative susceptibilities to chlorhexidine, a drug widely used to treat Acanthamoeba keratitis. "
04/01/1999 - "To evaluate the efficacy of chlorhexidine solution in the treatment of patients with Acanthamoeba keratitis. "
04/01/2015 - "In this prospective interventional case series, 31 eyes of 31 patients with Acanthamoeba keratitis (AK) were treated with chlorhexidine 0.02% as monotherapy, from April 2010 to April 2011. "
11/01/2008 - "To observe the ultrastructure of the strains of acanthamoeba isolated from acanthamoeba keratitis (AK), the morphologic changes of acanthamoeba after culture with 0.02% chlorhexidine, and ultrastructure characteristics of acanthamoeba in corneal tissue of AK. "
02/01/2008 - "The use of chlorhexidine as 1 agent in the medical management of Acanthamoeba keratitis may not eradicate the organisms."
04/15/1993 - "We believe the addition of polyhexamethylene biguanide to our treatment regimen in Acanthamoeba keratitis dramatically aided and hastened the clinical improvement in five consecutive patients and may, with early diagnosis, increase the number of medical cures."
05/01/1998 - "Is polyhexamethylene biguanide alone effective for Acanthamoeba keratitis?"
08/01/1998 - "Acanthamoeba keratitis in New Zealand, including two cases with in vivo resistance to polyhexamethylene biguanide."
02/01/1998 - "Polyhexamethylene biguanide treatment for Acanthamoeba keratitis."
01/01/1998 - "The reason for the apparent decline in incidence of Acanthamoeba keratitis is believed to be due to the introduction by industry over the last 3 years of sterile multipurpose (cleaning and disinfecting) solutions (MPS) containing polyhexamethylene biguanide to achieve their current popularity. "
01/01/1995 - "A combination of Brolene and Neomycin is the best approach in treating Acanthamoeba keratitis. "
10/01/1997 - "This study investigates the clinical outcome of Acanthamoeba keratitis treated with polyhexamethyl biguanide (PHMB) and propamidine isethionate (Brolene). "
01/01/2015 - "A 48-year-old woman who is a contact lens wearer presented with unilateral ACANTHAMOEBA keratitis, confirmed by PCR, which responded initially to topical polyhexamethylene biguanide (PHMB) and brolene. "
01/01/2011 - "Acanthamoeba keratitis was induced in Chinese hamsters; who were randomly assigned to one of the animal groups: UV-A + B2, propamidine isethionate (Brolene; Sanofi-Aventis, Ellerslie, Auckland, Australia), UV-A + B2 + propamidine isethionate (Brolene), only UV-A, only B2, and blank. "
05/01/2002 - "To point out that acanthamoeba keratitis can show therapeutical resistance to dibrome propamidine isethionate (Brolene). "
05/01/2012 - "By early diagnosis, using triple-topical therapy (polyhexamid, propamidinisoethionat, neomycin) acanthamoeba keratitis often heals appropriately. "
01/01/1995 - "A combination of Brolene and Neomycin is the best approach in treating Acanthamoeba keratitis. "
05/01/1999 - "Propamidine isethionate and neomycin are an effective treatment for Acanthamoeba keratitis. "
05/01/1999 - "Results of a trial of combined propamidine isethionate and neomycin therapy for Acanthamoeba keratitis. "
12/01/2013 - "After early diagnosis acanthamoeba keratitis can often be successfully treated using triple topical therapy with polyhexamide, propamidine isethionate and neomycin. "
|5.||Adrenal Cortex Hormones (Corticosteroids)IBA
09/01/1995 - "With timely diagnosis and medical treatment with a combination of antiamebic drugs and avoidance of topical corticosteroids, most cases of Acanthamoeba keratitis can be cured, with an excellent prognosis for visual recovery."
09/01/2013 - "Presumed late recurrence of Acanthamoeba keratitis exacerbated by exposure to topical corticosteroids."
12/01/2011 - "The majority of respondents (62.2%) reported using topical corticosteroids at least some of the time for acanthamoeba keratitis. "
05/01/1997 - "Topical corticosteroids were not associated with a higher rate of medical treatment failure in patients with Acanthamoeba keratitis. "
05/01/1997 - "To clarify the role of topical corticosteroids in the management of Acanthamoeba keratitis. "
02/01/2012 - "Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters."
02/01/2012 - "The aim of the study therefore was to assess the therapeutic potential of miltefosine on Acanthamoeba keratitis-infected hamster eyes. "
02/01/2012 - "Miltefosine appeared to hold necessary therapeutic properties for the treatment of Acanthamoeba keratitis."
06/01/2011 - "Although hexadecylphosphocholine is a potential agent for treatment of Acanthamoeba keratitis and systemic infections, in clinical practice the possible insusceptibility of the amoebic strain should be considered for optimizing therapy."
03/01/2002 - "Hexadecylphosphocholine may be a promising new candidate for the topical treatment of Acanthamoeba keratitis and, conceivably, even for the oral treatment of granulomatous amoebic encephalitis."
04/01/2002 - "[Acanthamoeba keratitis treated with propamidine and polyhexamethyl biguanide (PHMB)]."
10/01/1997 - "Outcome of acanthamoeba keratitis treated with polyhexamethyl biguanide and propamidine."
01/01/1996 - "The combination of topical chlorhexidine and propamidine was very effective for treating Acanthamoeba keratitis provided the drugs were continued for a sufficient period. "
04/01/2002 - "To report patients with acanthamoeba keratitis treated with the association of propamidine (Brolene) and polyhexamethylbiguanide (PHMB) 0.02%. "
04/01/2000 - "Propamidine and polyhexamethylene biguanide drops are recommended as initial choices for the treatment of Acanthamoeba keratitis. "
|8.||Contact Lens Solutions (Contact Lens Solution)IBA
01/15/2013 - "The Fusarium and Acanthamoeba keratitis outbreaks of years past were a wake-up call to manufacturers, ECPs, and regulatory agencies that risk cannot be managed without diligence, and that the complex relationship between contact lens materials, contact lens solutions, and compliance needs to be better understood in order to optimize the efficacy of contact lens care and improve care guidelines."
02/01/2012 - "Since the recall of these specific contact lens solutions, the rate of Acanthamoeba keratitis has remained above the expected baseline, indicating unidentified risk factors that may include environmental exposures. "
01/01/2012 - "Increase in acanthamoeba keratitis may be associated with use of multipurpose contact lens solution."
08/01/2009 - "National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States."
02/01/2009 - "MoisturePlus contact lens solution as a source of acanthamoeba keratitis."
11/01/2003 - "Furthermore, as antibodies produced both prior to and after infection reduced clinical symptoms of disease, the protein may represent an important immunotherapeutic target for Acanthamoeba keratitis."
01/01/2015 - "We developed an immunochromatographic assay kit that uses fluorescent silica nanoparticles bound to anti-Acanthamoeba antibodies (fluorescent immunochromatographic assay [FICGA]) and evaluated its efficacy for the detection of Acanthamoeba and diagnosis of Acanthamoeba keratitis (AK). "
01/01/2002 - "However, immunization via mucosal surfaces induces anti-Acanthamoeba IgA antibodies in the tears and provides solid protection against the development of Acanthamoeba keratitis. "
05/01/2001 - "Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies."
07/01/1999 - "These data show that monoclonal anti- Acanthamoeba IgA antibodies can protect against Acanthamoeba keratitis and suggest that this occurs by inhibiting adhesion of the parasite to the corneal epithelium."
|10.||Riboflavin (Vitamin B2)FDA LinkGeneric
03/01/2015 - "Given the in vitro efficacy of riboflavin combined with UV-A against cystic forms of A. castellani and excellent in vivo tolerance of the procedure, the treatment of acanthamoeba keratitis might be improved by this new therapeutic approach."
02/01/2013 - "Treatment of Acanthamoeba keratitis by corneal CXL (riboflavin/ultraviolet A) did not prove effective in decreasing the intensity and severity of Acanthamoeba keratitis."
02/01/2013 - "To evaluate the efficacy of corneal cross-linking (CXL; riboflavin/ultraviolet A) as a simple therapy for Acanthamoeba keratitis. "
05/01/2011 - "Ultraviolet-a light and riboflavin therapy for acanthamoeba keratitis: a case report."
02/01/2011 - "To present the first 3 cases of Acanthamoeba keratitis (AK), unresponsive to medical treatment, that were successfully treated with a novel adjunctive therapy using ultraviolet light A (UVA) and riboflavin (B2). "
08/01/2007 - "PTK and DLKP were found to be effective surgical procedures, especially for advanced Acanthamoeba keratitis that fails to respond to medical therapy and corneal debridement."
01/01/1988 - "In these three cases, the early diagnosis of Acanthamoeba keratitis coupled with wide epithelial debridement and medical therapy proved effective in eradicating the protozoan. "
04/01/2012 - "To study the safety and efficacy of treating early-stage Acanthamoeba keratitis (AK) with 20% alcohol-assisted epithelial debridement. "
04/01/2012 - "Treatment of early Acanthamoeba keratitis with alcohol-assisted epithelial debridement."
01/01/1998 - "Early diagnosis and wide epithelial debridement are important elements in the successful treatment of Acanthamoeba keratitis. "
02/01/2000 - "Acanthamoeba keratitis is probably quite common, especially in contact lens wearers, although more than half of the patients in this study did not wear contact lenses."
01/01/1999 - "Patients with Acanthamoeba keratitis in the Scottish study, all of whom wore contact lenses, were compared with 46 healthy asymptomatic contact lens-wearing controls. "
09/01/1998 - "Unworn soft and rigid gas-permeable contact lenses were inoculated with an Acanthamoeba keratitis strain to study the protozoon's ability to adhere. "
04/01/2015 - "Improper care and usage of contact lenses is a major risk factor for Acanthamoeba keratitis. "
06/01/2014 - "Acanthamoeba spp. commonly cause Acanthamoeba keratitis which is typically associated with the wear of contact lenses. "
11/01/2004 - "Penetrating keratoplasty is an effective treatment for medically unresponsive acanthamoeba keratitis. "
11/01/2004 - "[Clinical study of the treatment of acanthamoeba keratitis by penetrating keratoplasty]."
05/01/1984 - "After two penetrating keratoplasties, histopathologic examination and electron microscopic studies established the diagnosis of Acanthamoeba keratitis. "
05/01/2013 - "The infected cornea removed from a patient with Acanthamoeba keratitis during therapeutic penetrating keratoplasty was analyzed by immunohistochemistry. "
07/01/2011 - "Early diagnosis and prudent treatment of Acanthamoeba keratitis are the keys to restoring vision and avoiding the subsequent need for penetrating keratoplasty."
|4.||Corneal Transplantation (Keratoplasty)
08/01/2007 - "To report the efficacy of phototherapeutic keratectomy (PTK) and deep lamellar keratoplasty (DLKP) in the treatment of Acanthamoeba keratitis. "
01/01/2016 - "Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis Poorly Responsive to Medical Treatment."
01/01/2015 - "To report the risk factors for and outcomes of therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis (AK). "
01/01/2015 - "Therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis: risk factors, outcomes, and summary of the literature."
01/01/2014 - "Deep anterior lamellar keratoplasty for acanthamoeba keratitis complicating the use of Boston scleral lens."
06/01/2014 - "With most of the literature focusing on contact lens related Acanthamoeba keratitis, ophthalmologists may hesitate to diagnose this entity in patients without lenses. "
02/01/2007 - "To report four cases of Acanthamoeba keratitis related to the overnight wearing of orthokeratology lenses. "
08/01/2006 - "There are reports of young patients experiencing serious adverse events, particularly bacterial and Acanthamoeba keratitis while using these lenses, although incidence rates are unknown. "
12/01/2003 - "Overnight wear of orthokeratology lenses may induce Acanthamoeba keratitis."
06/17/1995 - "The crude relative risk for developing acanthamoeba keratitis with the use of daily wear disposable lenses was 49.45 (95% confidence interval 6.53 to 2227; P < 0.001) compared with conventional soft lenses (the referent). "