Angle-Closure Glaucoma (Glaucoma, Angle Closure)

A form of glaucoma in which the intraocular pressure increases because the angle of the anterior chamber is blocked and the aqueous humor cannot drain from the anterior chamber.

Also Known As:

Glaucoma, Angle Closure; Glaucoma, Angle-Closure; Glaucoma, Narrow-Angle; Glaucoma, Uncompensated; Glaucoma, Uncompensative; Angle Closure Glaucoma; Angle Closure Glaucomas; Angle-Closure Glaucomas; Closed-Angle Glaucoma; Closed-Angle Glaucomas; Glaucoma, Closed Angle; Glaucoma, Narrow Angle; Glaucomas, Angle Closure; Glaucomas, Angle-Closure; Glaucomas, Closed-Angle; Glaucomas, Narrow-Angle; Glaucomas, Uncompensated; Glaucomas, Uncompensative; Narrow-Angle Glaucoma; Narrow-Angle Glaucomas; Uncompensated Glaucoma; Uncompensated Glaucomas; Uncompensative Glaucoma; Uncompensative Glaucomas; Glaucoma, Closed-Angle

Networked: 1667 relevant articles (101 outcomes, 161 trials/studies)

Relationship Network

Disease Context: Research Results

Eye Diseases: 3522
- Ocular Hypertension: 3271
  - Glaucoma: 24513
    - Angle-Closure Glaucoma: 1667
      - Nanophthalmos 1

Related Diseases

1.	Cataract (Cataracts)
2.	Open-Angle Glaucoma (Glaucoma, Open Angle)
3.	Glaucoma
4.	Ocular Hypertension (Glaucoma, Suspect)
5.	Angle-Closure Glaucoma (Glaucoma, Angle Closure)

Experts

1.	Aung, Tin: 24 articles (01/2022 - 08/2002)
2.	Lai, Jimmy S M: 18 articles (01/2021 - 06/2002)
3.	Tham, Clement C Y: 17 articles (05/2015 - 06/2002)
4.	Lam, Dennis S C: 17 articles (01/2015 - 06/2002)
5.	Sun, Xinghuai: 14 articles (01/2022 - 08/2014)
6.	Sihota, Ramanjit: 12 articles (10/2021 - 04/2003)
7.	Liu, Xing: 12 articles (01/2021 - 08/2008)
8.	Nongpiur, Monisha E: 11 articles (01/2022 - 04/2011)
9.	Zhang, Xiulan: 11 articles (01/2022 - 06/2007)
10.	Ge, Jian: 11 articles (01/2020 - 06/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Angle-Closure Glaucoma:

1.	Latanoprost (Xalatan)FDA Link 02/01/2005 - "The aim of this study was to evaluate the efficacy of 0.005% latanoprost in lowering intraocular pressure (IOP) in patients with chronic angle-closure glaucoma (CACG) and no visible ciliary-body face. " 02/01/2005 - "Efficacy of latanoprost in patients with chronic angle-closure glaucoma and no visible ciliary-body face: a preliminary study." 08/01/2002 - "Two independent, prospective trials were recently conducted to assess the efficacy of latanoprost in reducing intraocular pressure (IOP) in patients with primary angle-closure glaucoma (PACG). " 03/01/2016 - "To systematically evaluate the safety and efficacy of latanoprost monotherapy for the treatment of patients with angle-closure glaucoma. " 01/01/2009 - "Efficacy of latanoprost in management of chronic angle closure glaucoma."
2.	ArgonIBA 09/01/2002 - "To study whether argon laser peripheral iridoplasty (ALPI) is as effective and safe as conventional systemic medications in treatment of acute primary angle-closure glaucoma (PACG) when immediate laser peripheral iridotomy is neither possible nor safe. " 06/01/1982 - "Argon laser peripheral iridotomy appears to be a laser peripheral iridotomy appears to be a safe and effective means of treating primary angle closure glaucoma." 01/01/1999 - "To study the efficacy and safety of limited (180 degrees) argon laser peripheral iridoplasty (ALPI) as a first-line treatment for acute primary angle closure glaucoma (PACG) without the use of systemic anti-glaucomatous medications. " 12/01/1998 - "This study aimed to examine the intraocular pressure (IOP)-lowering effects and safety of immediate argon laser peripheral iridoplasty (ALPI) as a first-line treatment for acute primary angle-closure glaucoma (PACG). " 05/01/1993 - "[Efficacy of argon and Nd:YAG laser combined in the treatment of primary chronic closed-angle glaucoma]."
3.	acceleratory factor from growth hormone (AcG)IBA 01/01/2023 - "The aim of the study was to investigate the clinical effectiveness and safety of sclerotonyxis in acute angle-closure glaucoma (ACG) with persistent high intraocular pressure (IOP). " 08/16/2021 - "In this study, we examined a Han RP family with concomitant angle-closure glaucoma (ACG), performed an inductive analysis of their clinical features and assistant results, and applied whole-exome sequencing (WES) technology for a molecular diagnosis. " 03/01/2014 - "The aim of this study was to report the characteristics of angle closure glaucoma (ACG) in eye clinic patients of University College Hospital (UCH), Ibadan, Nigeria. " 01/01/2014 - "In addition, the group of patients with chronic angle-closure glaucoma (ACG) from the Beijing Eye Study (n = 37) was merged with a group of patients with chronic ACG from the Tongren hospital (n = 52). " 09/01/2005 - "This study was conducted to determine the usefulness of peripheral anterior chamber depth assessment in angle-closure glaucoma (ACG) screening in Japanese subjects. "
4.	Bimatoprost (Lumigan)FDA Link 01/01/2011 - "Efficacy of bimatoprost 0.03% in reducing intraocular pressure in patients with 360° synechial angle-closure glaucoma: a preliminary study." 01/01/2011 - "In this study, exclusively involving patients with 360° synechial angle-closure glaucoma and no visual potential, bimatoprost 0.03% treatment demonstrated a statistically significant IOP reduction. " 01/01/2011 - "To assess efficacy and safety profile of bimatoprost 0.03% in lowering intraocular pressure (IOP) in 360° synechial angle-closure glaucoma patients. " 08/01/2007 - "The aim of this study was to compare the long-term efficacy of bimatoprost 0.03% monotherapy in primary open angle glaucoma (POAG) versus primary chronic angle closure glaucoma (PCACG) eyes. " 06/01/2009 - "To compare the intraocular pressure (IOP) lowering efficacy and side effects of latanoprost 0.005% and bimatoprost 0.03% in subjects with chronic primary angle closure glaucoma (PACG). "
5.	Retinaldehyde (Retinal)IBA 03/01/2007 - "To detect the objective structure changes of the retinal nerve fiber layer (RNFL) in primary acute angle closure glaucoma (PAACG) and to evaluate the efficacy of quantitative assessment of RNFL thickness with optical coherence tomography (OCT). " 08/30/2023 - "This study aims to investigate the changes of retinal vascular system in primary angle-closure glaucoma and acute primary angle closure by Optical Coherence Tomography Angiograph and to evaluate the diagnostic ability of changes of vessel density in different sectors and layers of optic disc and macular area in APAC and PACG. " 03/01/2023 - "The purpose of the study was to investigate whether the position of the central retinal vascular trunk (CRVT), as a surrogate for lamina cribrosa (LC) offset, is associated with the dominant hemisphere of visual field defect in primary angle-closure glaucoma (PACG) eyes. " 10/03/2022 - "To study the topographic relationship between parapapillary choroidal microvasculature dropout (MvD) and parapapillary retinal nerve fiber layer (RNFL) defect in primary angle-closure glaucoma (PACG) eyes. " 03/01/2001 - "The aim of this study was to document the time-course of retinal dysfunction by pattern-electroretinography (PERG) in eyes of the DBA/2NNia substrain of mouse that develop an inherited angle-closure glaucoma. "
6.	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/01/2023 - "A 67-year-old caucasian female with advanced primary angle-closure glaucoma on four medications with an intraocular pressure (IOP) of 26 mm Hg was listed for a PMS insertion with mitomycin C (MMC). " 11/01/2019 - "We report the surgical technique of a new modified fornix-based separate-site phacotrabeculectomy, with mitomycin C (MMC) application, in both primary open angle and angle closure glaucoma. " 01/01/2015 - "To determine the occurrence of intraoperative and postoperative complications up to three years after primary phacotrabeculectomy with intraoperative use of Mitomycin C (MMC) in primary open angle (POAG) and primary angle closure glaucoma (PACG) patients, and the effect of postoperative complications on surgical outcome. " 01/01/2020 - "Mitomycin C-augmented Phacotrabeculectomy Versus Phacoemulsification in Primary Angle-closure Glaucoma: A Randomized Controlled Study." 01/01/2020 - "Response to: Mitomycin C-augmented Phacotrabeculectomy Versus Phacoemulsification in Primary Angle-closure Glaucoma: A Randomized Controlled Study."
7.	Pilocarpine (Ocusert)FDA LinkGeneric 05/01/1999 - "The finding that pilocarpine increases angular width in patients with narrow angles indicates that this agent is useful for treating patients with narrow angles and angle closure glaucoma. " 06/01/1997 - "Pilocarpine has been well recognized as the drug of choice for acute angle-closure glaucoma. " 01/01/1997 - "A comparative study of Ocusert Pilo 40, intensive pilocarpine and low-dose pilocarpine in the initial treatment of primary acute angle-closure glaucoma." 04/01/1989 - "Pilocarpine, a first choice drug for primary angle closure glaucoma (PACG), is reported to produce shallow anterior chamber and posterior synechia and consequently a small immobile pupil. " 10/01/1984 - "The treatment of acute attack of primary angle-closure glaucoma by pilocarpine ocusert system."
8.	Antiglaucoma AgentsIBA 01/01/2023 - "Ultrasound cyclo plasty (UCP) can be useful in decreasing the intraocular pressure (IOP) and burden of antiglaucoma medications in eyes with primary angle closure glaucoma (PACG). " 09/01/2014 - "A 35-year-old male patient, diagnosed with acute angle-closure glaucoma, did not improve despite intensive treatment with antiglaucoma medications. " 11/09/2010 - "Both phacotrabeculectomy and short-term anti-glaucoma medications can decrease the MUC5AC in the tear fluid of primary angle-closure glaucoma patients. " 04/01/2001 - "To study the efficacy and safety of diode laser peripheral iridoplasty as a first-line treatment of acute primary angle-closure glaucoma (PACG) without the use of systemic anti-glaucoma medications. " 12/01/2022 - "Such was our case an elderly primigravida 10 weeks of gestation who had an acute episode of angle closure glaucoma with diminishing vision, who was managed both medically (anti-glaucoma drugs) and surgically (trabeculectomy). "
9.	Bevacizumab (Avastin)FDA Link 02/01/2021 - "Erratum to: A Case of Refractory Acute Angle Closure Glaucoma after an Intravitreal Bevacizumab Injection." 12/01/2020 - "A Case of Refractory Acute Angle Closure Glaucoma after an Intravitreal Bevacizumab Injection." 01/01/2010 - "[Use of bevacizumab as an additional strategy in angle closure glaucoma--case report]." 01/01/2009 - "We report the case of an acute angle-closure glaucoma that occurred immediately after an intravitreal injection of 0.05 ml of bevacizumab. " 01/01/2009 - "[Acute angle-closure glaucoma complicating an intravitreal injection of bevacizumab]."
10.	Synthetic Prostaglandins (Prostaglandin Analogues)IBA 12/01/2009 - "To evaluate the intraocular pressure (IOP)-lowering efficacy of prostaglandin analogs topical medications in patients with chronic angle-closure glaucoma (CACG). " 09/01/2011 - "Prostaglandin analogues in angle closure glaucoma." 12/01/2009 - "A meta-analysis of topical prostaglandin analogs in the treatment of chronic angle-closure glaucoma." 08/01/2005 - "Four eyes of three patients with chronic angle closure glaucoma developed choroidal detachment after using topical prostaglandin analogs. " 01/01/2009 - "latanoprost, a prostaglandin analogue, is effective in reducing IOP in chronic angle closure glaucoma patients and its efficacy is not affected by the degree of angle closure by peripheral anterior synechiae."

Therapies and Procedures

1.	Phacoemulsification 01/01/2021 - "The purpose of this study was to evaluate the safety and efficacy of cyclophotocoagulation under microscopy combined with phacoemulsification in patients with primary chronic angle-closure glaucoma. " 11/01/2023 - "To evaluate the safety and efficacy of phacoemulsification as a first line treatment of acute angle closure glaucoma (AACG) and to evaluate the preoperative and postoperative anterior chamber angle width and anterior chamber parameters using anterior segment OCT(AS-OCT) and Pentacam. " 04/01/2010 - "[Acute angle closure and angle closure glaucoma: Phacoemulsification as first-line treatment]." 01/01/2021 - "Phacoemulsification with Goniosynechialysis versus Phacoemulsification Alone in Angle-Closure Glaucoma: A Meta-Analysis of Randomized Controlled Trials." 01/01/2019 - "Phacoemulsification with or without goniosynechialysis for angle-closure glaucoma: a global Meta-analysis based on randomized controlled trials."
2.	Lasers (Laser) 01/01/1991 - "It thus appears that a combination of goniosynechialysis and laser gonioplasty may be effective in the management of refractory angle-closure glaucoma in the presence of an extremely narrow angle." 09/01/1987 - "While laser iridotomies have proven most effective in the treatment of acute angle-closure glaucoma, there is a diversity of opinion regarding the treatment of chronic forms, in particular when the congestive phase has been of long duration (e.g., 3 to 14 days). " 01/01/1996 - "The dark-room prone-position test could be useful in evaluating the pupillary block component in angle-closure glaucoma eyes and helpful in making a decision for laser iridotomy." 08/01/1992 - "Laser iridotomy is generally a safe and effective procedure for narrow-angle glaucoma. " 09/01/1991 - "During the past decade, laser iridotomy has replaced surgery as first-line treatment in angle-closure glaucoma. "
3.	Trabeculectomy (Trabeculoplasty) 01/01/2019 - "ALPI is relatively effective and safe to prevent angle-closure glaucoma and avoid trabeculectomy in patients with PIS. " 12/01/2015 - "The safety and efficacy of modified minimally invasive trabeculectomy for the treatment of primary chronic angle-closure glaucoma." 10/01/2021 - "This study aims to report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with primary angle-closure glaucoma (PACG). " 04/21/2014 - "The purpose of this study was to evaluate changes in choroidal thickness (CT) in advanced or late-stage primary angle closure glaucoma (PACG) patients who had undergone trabeculectomy. " 04/06/2023 - "Phaco-goniosynechialysis versus phaco-trabeculectomy in patients with refractory primary angle-closure glaucoma: a comparative study."
4.	Iridectomy 01/01/1977 - "In most cases, the angle-closure glaucoma associated with the plateau iris configuration is cured by a peripheral iridectomy. " 01/01/1979 - "Management of chronic or intermittent primary angle-closure glaucoma: a long-term follow-up of the results of peripheral iridectomy used as an initial procedure." 01/01/1975 - "The other group of patients had reversible angle-closure glaucoma associated with anatomically small anterior segments, and typically responded well to iridectomy. " 01/01/1974 - "Indentation gonioscopy and efficacy of iridectomy in angle-closure glaucoma." 01/01/2020 - "In this study, we report a case of new ODP-M detected after surgical iridectomy in a patient with primary angle-closure glaucoma (PACG) with a preoperative normal retina and optic nerve. "
5.	Intraocular Lens Implantation 01/01/2017 - "Early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma: an economic evaluation based on data from the EAGLE trial." 05/23/2011 - "The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial." 01/01/2017 - "To investigate the cost-effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma (PACG) compared to standard care. " 03/01/2009 - "Clinical reports of lensectomy with posterior chamber intraocular lens implantation in the treatment of acute, chronic, and secondary angle-closure glaucoma describe very favorable results. " 09/01/2008 - "To report a case of angle closure glaucoma after piggyback intraocular lens implantation and its treatment. "