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HLA-B8 Antigen (HLA B8 Antigen)

A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*08 allele family.
Also Known As:
HLA B8 Antigen; HLA Class I Histocompatibility Antigen, B-8 alpha Chain; HLA-B8; Antigen, HLA-B8; HLA Class I Histocompatibility Antigen, B 8 alpha Chain
Networked: 239 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bello, Murilo Lamim: 1 article (06/2021)
2. Fernandes, Tácio Vinício Amorim: 1 article (06/2021)
3. da Costa, Aline Silva: 1 article (06/2021)
4. de Souza, Theo Luiz Ferraz: 1 article (06/2021)
5. Einollahi, Behzad: 1 article (11/2015)
6. Futohi, Farzaneh: 1 article (11/2015)
7. Nemati, Eglim: 1 article (11/2015)
8. Rostami, Zohre: 1 article (11/2015)
9. Saber, Azadeh: 1 article (11/2015)
10. Abdul-Moneam, Mohamed: 1 article (09/2014)

Related Diseases

1. Graves Disease (Basedow Disease)
2. Myasthenia Gravis
3. Fibrosis (Cirrhosis)
06/01/1990 - "Remission (79% vs. 71%), relapse after drug withdrawal (76% vs. 71%), treatment failure (13% vs. 6%), progression to cirrhosis (46% vs. 32%), and death from liver failure (6% vs. 3%) occurred as frequently in patients with and without HLA-B8. "
05/01/1980 - "Men with alcoholic hepatitis with or without cirrhosis showed an increased incidence of the histocompatibility antigen HLA-B8 (P less than 0.02). "
06/19/1982 - "To test whether the increased prevalence of HLA-B8 reported in patients with alcoholic cirrhosis is due to the antigen being a genetic marker of susceptibility to liver damage from alcohol, patients who had cirrhosis of comparable clinical and histological severity were investigated for HLA-B8 status and cumulative alcohol intake. "
09/25/1976 - "Determination of histocompatibility antigens in 63 patients with alcoholic liver disease showed that HLA-B8 was more prevalent in patients with cirrhosis than in controls, but among those with fatty liver and minimal fibrosis the prevalence of this antigen was normal. "
06/01/1990 - "To assess the clinical and prognostic implications of human leukocyte antigen B8 in corticosteroid-treated severe autoimmune chronic active hepatitis, 81 consecutive patients were tested for histocompatibility antigens on the A and B loci, treated with corticosteroids, and followed prospectively for 111 +/- 8 mo. The 47 patients with HLA-B8 were younger (38 +/- 2 yr vs. 48 +/- 2 yr; p less than 0.01), had higher serum levels of aspartate aminotransferase (658 +/- 60 U/L vs. 465 +/- 49 U/L; p = 0.02) and bilirubin (7 +/- 1 mg/dl vs. 2.8 +/- 0.4 mg/dl; p = 0.003), and more commonly had histologic features of bridging necrosis, multilobular necrosis, and cirrhosis (85% vs. 56%; p less than 0.01) at presentation than the 34 patients without HLA-B8. "
4. Liver Failure
5. Chronic Kidney Failure (Chronic Renal Failure)

Related Drugs and Biologics

1. Antigens
2. HLA-A28 antigen
3. Antithyroid Agents (Antithyroid Drugs)
4. HLA-DR11 antigen
5. Histocompatibility Antigens (Histocompatibility Antigen)
6. HLA Antigens (Human Leukocyte Antigens)
7. HLA-B7 Antigen (HLA B7 Antigen)
8. HLA-DR2 Antigen (HLA DR2 Antigen)
9. HLA-B51 Antigen
10. HLA-B44 Antigen

Related Therapies and Procedures

1. Thymectomy
2. Kidney Transplantation
3. Aftercare (After-Treatment)
4. Therapeutics
5. Liver Transplantation