HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

HLA-B8 Antigen (HLA B8 Antigen)

Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is in linkage disequilibrium with HLA-A1 and HLA-DR3. This explains the fact that though HLA-B8 was originally associated with several diseases, including celiac disease, dermatitis herpetiformis, and myasthenia gravis, their association with HLA-DR3 is now considered more significant.
Also Known As:
HLA B8 Antigen; HLA-B8; Antigen, HLA-B8
Networked: 210 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Al-Attiyah, Rajaa: 1 article (09/2014)
2. Al-Muzairai, Ibrahim: 1 article (09/2014)
3. Mosaad, Youssef M: 1 article (09/2014)
4. Abdul-Moneam, Mohamed: 1 article (09/2014)
5. Mansour, Merveet: 1 article (09/2014)
6. Shahin, Manal: 1 article (09/2014)
7. Al-Otabi, Turky: 1 article (09/2014)
8. Bjarnadottir, Kristjana: 1 article (09/2013)
9. Gislason, Thorarinn: 1 article (09/2013)
10. Petursdottir, Dyrleif: 1 article (09/2013)

Related Diseases

1. Myasthenia Gravis
2. Fibrosis (Cirrhosis)
06/01/1990 - "Remission (79% vs. 71%), relapse after drug withdrawal (76% vs. 71%), treatment failure (13% vs. 6%), progression to cirrhosis (46% vs. 32%), and death from liver failure (6% vs. 3%) occurred as frequently in patients with and without HLA-B8. "
05/01/1980 - "Men with alcoholic hepatitis with or without cirrhosis showed an increased incidence of the histocompatibility antigen HLA-B8 (P less than 0.02). "
06/19/1982 - "To test whether the increased prevalence of HLA-B8 reported in patients with alcoholic cirrhosis is due to the antigen being a genetic marker of susceptibility to liver damage from alcohol, patients who had cirrhosis of comparable clinical and histological severity were investigated for HLA-B8 status and cumulative alcohol intake. "
06/01/1990 - "To assess the clinical and prognostic implications of human leukocyte antigen B8 in corticosteroid-treated severe autoimmune chronic active hepatitis, 81 consecutive patients were tested for histocompatibility antigens on the A and B loci, treated with corticosteroids, and followed prospectively for 111 +/- 8 mo. The 47 patients with HLA-B8 were younger (38 +/- 2 yr vs. 48 +/- 2 yr; p less than 0.01), had higher serum levels of aspartate aminotransferase (658 +/- 60 U/L vs. 465 +/- 49 U/L; p = 0.02) and bilirubin (7 +/- 1 mg/dl vs. 2.8 +/- 0.4 mg/dl; p = 0.003), and more commonly had histologic features of bridging necrosis, multilobular necrosis, and cirrhosis (85% vs. 56%; p less than 0.01) at presentation than the 34 patients without HLA-B8. "
3. Liver Failure
4. Chronic Kidney Failure (Chronic Renal Failure)
5. Graves Disease (Basedow Disease)

Related Drugs and Biologics

1. Antigens
2. HLA-A28
3. HLA-DR11 antigen
4. Histocompatibility Antigens (Histocompatibility Antigen)
5. HLA Antigens (Human Leukocyte Antigens)
6. HLA-B7 Antigen (HLA B7 Antigen)
7. HLA-DR2 Antigen (HLA DR2 Antigen)
8. HLA-Bw51
9. HLA-B Antigens (HLA-B)
10. HLA-DR3 Antigen (HLA DR3 Antigen)

Related Therapies and Procedures

1. Thymectomy
2. Aftercare (After-Treatment)
3. Transplants (Transplant)
4. Liver Transplantation
5. Breast Implantation (Implantation, Breast)