4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine

A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.

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Networked: 98 relevant articles (10 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cheng, Wing Yin: 1 article (01/2017)
2.	Gallegos, Zachary R: 1 article (01/2017)
3.	Jin, Zixue: 1 article (01/2017)
4.	Krzeszinski, Jing Y: 1 article (01/2017)
5.	Saghatelian, Alan: 1 article (01/2017)
6.	Schwaid, Adam G: 1 article (01/2017)
7.	Wan, Yihong: 1 article (01/2017)
8.	Aggarwal, Nitin T: 1 article (07/2008)
9.	Campbell, William B: 1 article (07/2008)
10.	Gauthier, Kathryn M: 1 article (07/2008)

Related Diseases

1.	Paramyxoviridae Infections (Parainfluenza) 01/01/1991 - "Further studies in vitro showed that the drugs ETYA and BW755c were effective in inhibiting the replication of two additional orthopoxviruses, ectromelia and vaccinia viruses, but not human parainfluenza virus-3. "
2.	Ectromelia (Phocomelia) 01/01/1991 - "Further studies in vitro showed that the drugs ETYA and BW755c were effective in inhibiting the replication of two additional orthopoxviruses, ectromelia and vaccinia viruses, but not human parainfluenza virus-3. "
3.	Pleurisy (Pleuritis) 10/01/1982 - "BW755C produced a depressive effect on carrageenin-induced pleurisy, but on triple vaccine-induced pleurisy, BW755C produced only a slight depressive effect. " 01/01/1987 - "Both nonsteroidal anti-inflammatory drugs and a mixed lipoxygenase-cyclooxygenase inhibitor (BW 755C) preferentially inhibited fluid accumulation in RPAR pleurisy elicited with 5 mg BSA and 1 mg anti-BSA and in carrageenan pleurisy. " 03/01/1986 - "Furthermore, KME-4, when administered orally 5 h after the carrageenan, inhibited both monocyte numbers and exudate volume in a 24 h pleurisy and was more effective than indomethacin and BW755c which inhibited only monocyte migration. " 02/05/1982 - "In rat carrageenin pleurisy, dexamethasone (0.25 mg/kg p.o.) inhibited exudate accumulation in the pleural cavity throughout the period of testing while the non-steroidal anti-inflammatory drugs indomethacin (10 mg/kg p.o.) and BW755C (100 mg/kg p.o.) inhibited it for 6 and 9 h respectively after the intrapleural injection of carrageenin but not thereafter. " 02/05/1982 - "Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats."
4.	Pulmonary Edema 01/01/1995 - "BW-755C diminishes smoke-induced pulmonary edema." 01/01/1991 - "In contrast, EP10161, aspirin and BW755C significantly inhibited pulmonary edema by 49%, 30% and 27%, respectively. " 01/01/1987 - "Neither pretreatment with the LTD4/E4 antagonist, LY171883 (10 microM), nor the 5-lipoxygenase/cyclooxygenase inhibitor, BW755C (100 microM), attenuated the pulmonary edema. " 08/01/1994 - "Prevention of high-permeability pulmonary edema after smoke with BW-755C suggests that LTB4, may be etiologic, as previous work has eliminated LTC4, LTD4, and LTE4." 01/01/1995 - "We, therefore, hypothesized that acrolein, a component of smoke from burning cotton, might have a major role in producing pulmonary edema in sheep after cotton smoke inhalation and that BW-755C, a combined cyclo- and lipoxygenase inhibitor, would prevent the edema, whereas indomethacin, a cyclooxygenase inhibitor, would not. "
5.	Leukopenia 10/01/1986 - "The Paf-induced haemoconcentration and plasma exudation were significantly reduced by pretreatment with prednisolone (20 mg kg-1 s.c.) or BW755C (50 mg kg-1 p.o.), while Paf-induced leukopenia was unaffected by either drug. " 10/01/1986 - "The mixed cyclo-oxygenase/lipoxygenase inhibitor compound BW 755C was very effective in blocking bronchoconstriction by the highest dose of FMLP used, but failed to interfere with leukopenia. " 01/01/1989 - "To determine whether invading leukocytes mediate these responses, acute inflammatory cell influx was suppressed either by inducing leukopenia with nitrogen mustard or by administration of BW-755C, a mixed cyclooxygenase-lipoxygenase inhibitor. "

Related Drugs and Biologics

1.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2.	Lipoxygenase Inhibitors
3.	Dexamethasone (Maxidex)
4.	Lipoxygenase (Lipoxygenase-1)
5.	Indomethacin (Indometacin)
6.	5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
7.	Leukotriene D4
8.	Masoprocol (Actinex)
9.	Methysergide (Sansert)
10.	Leukotriene B4

Related Therapies and Procedures

1.	Controlled Hypotension
2.	Cautery
3.	Oral Administration