2-Chloroadenosine (2 Chloroadenosine)

2-Chloroadenosine. A metabolically stable analog of adenosine which acts as an adenosine receptor agonist. The compound has a potent effect on the peripheral and central nervous system.

Also Known As:

2 Chloroadenosine; Adenosine, 2-chloro-

Networked: 97 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Headrick, John P: 3 articles (01/2007 - 07/2002)
2.	Willems, Laura: 3 articles (01/2007 - 07/2002)
3.	Dubey, Raghvendra K: 2 articles (01/2020 - 12/2015)
4.	Gillespie, Delbert G: 2 articles (01/2020 - 12/2015)
5.	Imthurn, Bruno: 2 articles (01/2020 - 12/2015)
6.	Jackson, Edwin K: 2 articles (01/2020 - 12/2015)
7.	Mi, Zaichuan: 2 articles (01/2020 - 12/2015)
8.	Rosselli, Marinella: 2 articles (01/2020 - 12/2015)
9.	Bache, Robert J: 2 articles (08/2009 - 10/2008)
10.	Chen, Yingjie: 2 articles (08/2009 - 10/2008)

Related Diseases

1.	Seizures (Absence Seizure) 03/05/1991 - "Lower doses of 2-chloroadenosine provided significant protection against audiogenic seizures (66 and 331 pmol) when injected into the inferior colliculus. " 03/05/1991 - "2-Chloroadenosine infusion into the substantia nigra pars reticulata provided significant protection against electroshock seizures (1.66, 8.33 and 25 nmol) and audiogenic seizures (66, 331 pmol and 1.66 nmol). " 11/01/2010 - "Minimal clonic seizures in 18-day and older rats were suppressed by high doses of 2-chloroadenosine. " 07/01/2005 - "Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application." 11/14/1997 - "Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures."
2.	Self Mutilation 02/01/1988 - "After systemic administration of SKF-38393 or L-dopa, central microinjection of the adenosine agonists, 2-chloroadenosine or 5'-N-ethylcarboxamide adenosine, were effective in preventing self mutilation induced by these dopamine agonists in neonatally lesioned rats. "
3.	Ischemia 01/01/1997 - "2-Chloroadenosine (0.6 mg/kg, IV) was administered 5 min subsequent to ischemia. " 06/01/1993 - "This study evaluated the effects of an adenosine analogue, 2-chloroadenosine (2CA), on ischemia-reperfusion (IR) injury in rabbit lungs. " 07/01/2002 - "Coronary responses were selectively reduced: 2-chloroadenosine and ADP dilated with pEC(50)s of 8.4+/-0.1 and 7.4+/-0.1 in non-ischemic hearts versus 7.7+/-0.1 and 7.1+/-0.1 after 20-min ischemia (P<0.05). " 01/01/1996 - "3. It is concluded that 2-chloroadenosine treatment influenced ATP production and Na,K ATPase activity in ischemia and reperfusion (P < 0.05)." 01/01/1996 - "The effect of 2-chloroadenosine, an adenosine analogue, on brain ATP level and Na,K ATPase activity in ischemia and reperfusion was studied. "
4.	Neoplasms (Cancer) 02/11/2000 - "Furthermore, the administration of 2-chloroadenosine following the tumor cell challenge had little effect on the metastatic potential. " 02/11/2000 - "Treatment of mice with 2-chloroadenosine prior to the tumor cell challenge cancelled the suppression of not only metastasis but also the lung accumulation. " 11/01/1994 - "In this study we show that 2-chloroadenosine (2CA), a stable analogue of adenosine, inhibits, in a dose-dependent fashion, MHC-unrestricted killing of P815 tumor target cells by anti-CD3-activated killer (AK) lymphocytes. " 03/01/1988 - "The metastatic capacity of murine mammary tumor line 410.4 is greatly increased by treatment of the host with asialo-GM1 antiserum (5-fold), 2-chloroadenosine (4-fold) or k-carrageenan (2.5-fold). " 10/01/2008 - "Moreover, 2-Chloroadenosine is capable of modulating PAR-1 and IL-23 gene expression suggesting a modulation of cancer metastasis and immune system activity. "
5.	Bone Resorption 05/25/1983 - "Studies on the mechanisms by which 2-chloroadenosine stimulates bone resorption in tissue culture." 05/25/1983 - "The results suggest that 2-chloroadenosine stimulated bone resorption by a process which is dependent on osteoclastic activity. " 05/25/1983 - "The effect of 2-chloroadenosine on bone resorption was studied in calvarial bones from 6-7-day-old mice in organ culture. " 04/01/1985 - "Prostaglandin E2 and 2-chloroadenosine act in concert to stimulate bone resorption in cultured murine calvarial bones." 06/01/1982 - "The initial stimulatory effect on bone resorption by 2-chloroadenosine may therefore not depend on cyclic AMP. "

Related Drugs and Biologics

1.	Adenosine (Adenocard)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	Purinergic P1 Receptor Antagonists
4.	Pentylenetetrazole (Metrazol)
5.	Aminophylline (Carine)
6.	Phenobarbital (Luminal)
7.	Benzodiazepines
8.	Dopamine Agonists (Dopamine Agonist)
9.	2,3,4,5- Tetrahydro- 7,8- dihydroxy- 1- phenyl- 1H- 3- benzazepine (SKF 38393)
10.	Trimethadione (Tridione)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Microspheres (Microsphere)
3.	Intravenous Injections
4.	Injections
5.	Anesthesia