Foreign-Body Granuloma (Granuloma, Foreign Body)

Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.

Also Known As:

Networked: 429 relevant articles (5 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Ankylosis
2.	Temporomandibular ankylosis
3.	Essential Osteolysis
4.	Inflammation (Inflammations)
5.	Erythema

Experts

1.	Klinge, U: 5 articles (08/2014 - 12/2008)
2.	Binnebösel, M: 5 articles (05/2012 - 12/2008)
3.	Klinge, Uwe: 4 articles (01/2015 - 04/2007)
4.	Junge, K: 4 articles (05/2012 - 12/2008)
5.	Klink, C D: 4 articles (05/2012 - 02/2010)
6.	Otto, J: 3 articles (05/2012 - 02/2010)
7.	Schumpelick, V: 3 articles (01/2011 - 12/2008)
8.	Park, Young Min: 2 articles (03/2022 - 04/2014)
9.	Chang, Sung Eun: 2 articles (01/2021 - 12/2013)
10.	Lee, Mi Woo: 2 articles (01/2021 - 12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Foreign-Body Granuloma:

1.	SteroidsIBA 02/01/2022 - "Diagnosed with foreign body granuloma, the patient rejected the resection or steroids, but willingly took the experimental treatment of HOT instead. " 05/01/2019 - "Foreign-body granuloma formation following filler injections is most commonly seen with permanent fillers; these reactions can occur years following the injections and often require either an intralesional steroid injection or surgical excision. " 09/01/2010 - "The foreign body granulomas could not be treated satisfactorily with intralesional steroids, and the patient required a surgical excision of her granulomas. " 07/01/2008 - "Recurrent foreign body granuloma with airway obstruction: is there a role for steroids?" 09/01/1992 - "We thought that the steroid hormone elicited good results in the treatment of inoperable foreign-body granuloma."
2.	Hormones (Hormone)IBA 09/01/1992 - "We thought that the steroid hormone elicited good results in the treatment of inoperable foreign-body granuloma." 09/01/1992 - "[A case of foreign-body granuloma treated with steroid hormone]." 07/01/1954 - "II. Evolution of a foreign body granuloma (plant charcoal) in white mice treated with somatotropic hormone]."
3.	baysilon (polydimethylsiloxane)IBA 01/01/2002 - "Silastic removal was necessary in five cases due to its inducement of foreign body granuloma. " 01/01/2002 - "In our opinion the gold standard surgery of TMJ ankylosis today is represented by shaving of articular surfaces and subsequent arthroplasty with or without temporal muscle myofascial flap interposition, whereas the use of Silastic as alloplastic material could be associated to an increased persistence of the local symptoms and a higher risk of foreign body granuloma and it may favor ankylosis relapse and hinder rehabilitation." 09/01/1992 - "Eighteen cartilage grafts placed after Proplast (Vitek, Inc, Houston, TX) or Silastic (Dow Corning, Midland, MI) implants had been removed, all showed foreign-body granuloma with coexistent intact cartilage grafts. "
4.	SiliconesIBA 05/26/2020 - "Histopathological study of axillary lymph node revealed foreign body granulomas and macrophages phagocyting silicone. " 01/01/2020 - "Foreign body granulomas are a well-recognized complication of silicone exposure; however, they may be challenging to identify without a clear history. " 05/01/2015 - "Formation of a foreign body granuloma is one of the serious complications of silicone injection, which can be difficult to treat. " 07/15/2008 - "Here we report a case of foreign body granuloma in the thigh secondary to silicone injection in the buttocks. " 07/15/2008 - "Foreign body granuloma formation secondary to silicone injection."
5.	Hemostatics (Antihemorrhagics)IBA 01/01/2015 - "The study presents a clinical observation of foreign body granuloma, which is rare productive inflammation, developed on treatment with a hemostatic material upon removal of cerebral cavernoma. " 05/01/2013 - "The present study aimed to demonstrate why foreign-body granuloma induced by local hemostatic materials should be incorporated into the differential diagnosis of recurrent gastrointestinal stromal tumors post-operatively, particularly soon after surgical resection has been performed."
6.	Dermal FillersIBA 11/01/2021 - "A foreign body granuloma after dermal filler injection successfully treated with a combination of high-intensity focused ultrasound and quantum molecular resonance technology device." 08/01/2018 - "The aim of the paper was to evaluate the utility of high frequency ultrasound imaging for distinguishing between foreign body granulomas and nodular dermal filler deposits. " 08/01/2018 - "High-frequency ultrasound-based differentiation between nodular dermal filler deposits and foreign body granulomas." 03/01/2015 - "Foreign body granulomas may occur after the administration of any dermal filler. " 03/01/2015 - "Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment."
7.	Polyethylene (Polythene)IBA 06/01/2021 - "Postoperative pathology showed polyethylene debris in the soft tissue with an apparent multinucleated giant cell response, which was consistent with foreign body granuloma. " 11/01/2016 - "Foreign Body Granuloma Following Orbital Reconstruction with Porous Polyethylene." 05/01/2000 - "Foreign-body granulomas containing HDPE particles were seen at the bone-implant interface in animals given 10(8) particles. " 01/01/1999 - "Small particles of ultrahigh molecular weight polyethylene stimulate formation of foreign-body granulomas and bone resorption. " 01/01/1997 - "This study demonstrates that polyethylene wear products alone can cause massive osteolysis by triggering the formation of foreign body granuloma at the bone-implant interface."
8.	Polypropylenes (Polypropylene)IBA 12/01/2021 - "Interpretation of the results of a histopathological study of the kidney resection area indicates the development of a taft connective tissue structure around the prolene implant of the "patch" type in the shape of strands of dense granulation tissue surrounded by foreign body granulomas. " 01/01/2014 - "Polypropylene mesh with enlarged pores to 3 mm is associated with a similar strength of FBR in mesh pores and a reduced foreign body granuloma in comparison to a 1 mm pore lightweight and 0.5 mm pore heavyweight mesh." 12/01/2008 - "The diameters of the foreign body granulomas were significantly reduced in the UltraPro mesh group (41.7 +/- 5.5 microm) compared to the Prolene mesh group (48.7 +/- 7.7 microm). " 08/01/1995 - "Polypropylene was responsible for the majority of foreign-body granulomas. " 01/01/2016 - "A delayed foreign body granuloma associated with polypropylene sutures used in tendon transfer. "
9.	Capsules (Microcapsules)IBA 04/01/2016 - "The results of histologic studies indicated that the mass was pseudocystic and fluid-filled, surrounded by a fibrous capsule, and characterized as a foreign-body granuloma. " 06/01/2014 - "Analysis performed after 4 and 9 weeks indicated areas of foreign body granuloma without formation of a fibrous capsule." 01/01/1999 - "The inner surface of the capsule was often covered with numerous giant cells attesting to a foreign-body granuloma developed against the irregular outline of the episcleral implants. " 04/01/2015 - "Microscopic findings showed that the hematoma capsule consisted of collagenous tissue with chronic inflammatory infiltrate and foreign-body granuloma with foam cells and giant cells. " 02/01/2010 - "On postoperative day 60, the inflammatory and connective tissue formation was characterised by measuring the diameter of inner cellular infiltrate and outer fibrous capsule of the foreign body granuloma, and by verifying the collagen type I/III ratio. "
10.	Hyaluronic Acid (Hyaluronan)IBA 07/01/2023 - "Hyaluronic acid-induced foreign body granuloma in the upper lip." 01/01/2020 - "Delayed Foreign Body Granulomas in the Orofacial Region after Hyaluronic Acid Injection." 07/15/2020 - "Herein, we report a patient with foreign body granuloma formation that presented as multiple subcutaneous nodules on both arms, following injections of hyaluronic acid performed about six years earlier. " 02/01/2018 - "The purpose of this study is to present two additional cases of oral foreign body granulomas caused by liquid silicone and hyaluronic acid respectively and review the pertinent literature regarding the demographics, the clinical appearance, the histopathology and the treatment of these lesions. " 02/01/2018 - "Key words:Oral foreign body granuloma, hyaluronic acid, silicone, soft tissue filler."

Therapies and Procedures

1.	Sutures (Suture) 11/01/2021 - "Delayed Onset of Infectious Foreign Body Granuloma for Nonabsorbable Sutures After Open Achilles Tendon Repair: A Case Report." 11/01/2021 - "Histopathological examination detected many suture materials surrounded by xanthochromic necrotic lesions and the lesion was diagnosed as a foreign body granuloma. " 11/01/2021 - "Foreign body granulomas from sutures are more common among non-absorbable sutures compared to absorbable sutures and have been reported as a postoperative complication in a variety of medical fields. " 08/01/2019 - "Modifications of suture geometry alter the foreign body granuloma and the inflammatory reaction. " 12/01/2016 - "A Potential Complication of Barbed Sutures Preventing Foreign Body Granulomas Induced by Surgical Cloth Particles."
2.	Debridement 01/01/2006 - "Foreign body granuloma and fistulation occurred in 1 (9%) member of the study group, but was treated successfully with debridement; implant palpability subsided after 24 months. " 08/01/2007 - "Through debridement and decompression of neural structures and chronic damage caused by foreign body granulomas can be prevented. "
3.	Arthroplasty 12/01/2013 - "The patient underwent successful revision hip arthroplasty after the removal of the foreign body granuloma. " 02/01/2007 - "Removal of an intrapelvic foreign body granuloma and rerevision hip arthroplasty had to be performed within 2 years after the first revision." 01/01/2002 - "In our opinion the gold standard surgery of TMJ ankylosis today is represented by shaving of articular surfaces and subsequent arthroplasty with or without temporal muscle myofascial flap interposition, whereas the use of Silastic as alloplastic material could be associated to an increased persistence of the local symptoms and a higher risk of foreign body granuloma and it may favor ankylosis relapse and hinder rehabilitation."
4.	Rhinoplasty 10/01/2011 - "Efficacy of open rhinoplasty approach to foreign body granuloma of the nose." 06/01/2017 - "This is the longest reported duration between initial rhinoplasty and the exacerbation of foreign body granuloma. " 06/01/2017 - "This paper reports on a patient with delayed-onset edematous foreign body granuloma that had been caused by augmentation rhinoplasty performed using a silicone implant in conjunction with a liquid silicone injection 40 years earlier. " 06/01/2017 - "Delayed-Onset Edematous Foreign Body Granulomas 40 Years After Augmentation Rhinoplasty by Silicone Implant Combined with Liquid Silicone Injection."
5.	Injections 04/01/2009 - "Foreign body granulomas are a rare adverse reaction to injectable permanent fillers. " 04/01/2009 - "Oral foreign body granuloma: unusual presentation of a rare adverse reaction to permanent injectable cosmetic filler." 01/01/2007 - "Injectable cutaneous microimplants may occasionally cause either persistent local irritation or late skin reactions in the form of foreign body granulomas at the injected areas. " 02/01/2004 - "Purposely, cosmetic injections in orofacial tissues of various resorbable, biodegradable, or permanent fillers may be followed by development of foreign-body granulomas. " 01/01/1999 - "Foreign body granulomas due to injectable aesthetic microimplants."