|1.||Trapman, Jan: 2 articles (01/2011 - 11/2005)|
|2.||Rodriguez, Ronald: 2 articles (03/2010 - 05/2002)|
|3.||Horie-Inoue, Kuniko: 2 articles (01/2009 - 12/2004)|
|4.||Inoue, Satoshi: 2 articles (01/2009 - 12/2004)|
|5.||Rennie, Paul S: 2 articles (11/2007 - 11/2006)|
|6.||Onate, Sergio A: 2 articles (05/2006 - 09/2003)|
|7.||Gao, Allen C: 2 articles (05/2006 - 09/2003)|
|8.||Too, Catherine K L: 1 article (03/2014)|
|9.||Thomas, Lynn N: 1 article (03/2014)|
|10.||Koirala, Samir: 1 article (03/2014)|
11/01/1978 - "In this study biopsies from 16 cancer patients were taken before therapy was given, and the specimens were analyzed with regard to content of specific methyltrienolone-binding sites. "
01/01/2014 - "Principal component analysis with linear discriminant analysis of the Raman spectra was able to differentiate between cancer cells that were treated with MPA, R1881, and untreated."
11/01/2005 - "PC346Flu1 proliferation was inhibited in vitro by R1881 at 0.1 nM concentration, consistent with a slower tumor growth rate in intact males than in castrated mice. "
04/01/2001 - "AR from all of the tumors and cell lines bound [3H]R1881 with similar high affinity (mean Kd, 0.12 nM). "
01/01/1995 - "The inhibitory effect of R 1881 on a PgR-positive/AR-negative tumor suggested that R 1881 action was partially PgR-mediated. "
|2.||Prostatic Neoplasms (Prostate Cancer)
05/14/2009 - "Although several studies have used microarrays to identify AR-regulated genes in prostate cancer cell lines and in prostate tumours, we present here the results of gene expression microarray profiling of the androgen-responsive LNCaP prostate-cancer cell line treated with R1881 for the identification of androgen-regulated genes. "
05/01/2002 - "In vitro studies showed that our viral constructs preferentially kill PSA-positive prostate cancer cells in the presence of exogenous androgen (R1881). "
01/01/2011 - "Androgen regulation of TMPRSS2 is measured in commonly used LNCaP prostate cancer cells grown with and without the synthetic androgen R1881. "
12/01/2007 - "To investigate possible effects of androgen on SOCS-3 protein expression, two prostate cancer cell lines (PC3-AR and LAPC4) were treated with different concentrations of R1881. "
01/01/2006 - "We present the utility of massively parallel sequencing by synthesis for profiling the transcriptome of a human prostate cancer cell-line, LNCaP, that has been treated with the synthetic androgen, R1881. "
|3.||Breast Neoplasms (Breast Cancer)
03/01/2014 - "In summary, PRL and R1881, acting through Stat5 and AR, act cooperatively to stimulate CPD gene transcription in breast cancer cells. "
10/01/1988 - "Specific [3H]R1881 binding was found in four different gubernaculum fibroblast cultures (9,000-42,000 sites/cell) and MCF-7 human breast cancer cells (34,000 sites/cell) which were used as controls. "
12/01/1970 - "Antitumor efficacy and toxicity of methyltrienolone (NSC-92858) in advanced breast cancer."
03/01/2014 - "This study showed that synthetic androgen R1881 and PRL elevated CPD mRNA/protein levels in human MCF-7 and T47D breast cancer cells in a time-/dose-dependent manner. "
03/01/2014 - "Prolactin/Stat5 and androgen R1881 coactivate carboxypeptidase-D gene in breast cancer cells."
12/01/1985 - "This paper describes the dose-response inhibitory effects of a synthetic androgen, methyltrienolone, on the growth of a grade II endometrial adenocarcinoma in vitro. "
01/01/1986 - "The synthetic androgen 17 beta-hydroxy-17 alpha-[3H]methyl-4,9,11-estratrien-3-one (R1881) has been used as photoaffinity label to characterize androgen receptors in rat prostate, in a human transplantable prostatic adenocarcinoma (PC-82) and in calf uterus. "
01/11/2002 - "We show that androgens (dihydrotestosterone and R1881) down-regulate TGF-beta1-induced expression of TGF-beta1, c-Fos, and Egr-1 in the human prostate adenocarcinoma cell line, LNCaP. "
09/10/1999 - "In the present study we explored whether androgens (R1881), retinoids (all-trans- and 9-cis-retinoic acid: atRA and 9cRA), deltanoids (1alpha,25-dihydroxycholecalciferol: VD3) and thyroid hormone (triiodothyronine: T3) influence the production of IGFBPs by LNCaP prostatic adenocarcinoma cells and whether the observed changes affect tumor cell growth. "
|5.||Androgen-Insensitivity Syndrome (Testicular Feminization)
11/01/1984 - "Using conditions for optimal recovery of androgen receptor from human testes established by previous studies, we detected the presence of a high-affinity (dissociation constant = 3.2 X 10(-10) mol/L), low-capacity (4.2 X 10(-12) mol/mg DNA), androgen-binding protein when tritium-labeled R1881 was incubated at 4 degrees C with nuclear extracts from the gonads of control patients or from a patient with testicular feminization syndrome but not when incubated at 37 degrees C. "
07/01/1978 - "We have found a specific binding protein for synthetic progestins 6,7-[3H]methyltrienolone (R1881) and 17,21-dimethyl-19-norpregna-4,9-diene-3,20-dione (R5020) and in the testis cytosol from three "sisters" with the complete form of the testicular feminization syndrome. "
|1.||Androgen Receptors (Androgen Receptor)
|6.||Messenger RNA (mRNA)
|7.||DNA (Deoxyribonucleic Acid)
|9.||Tretinoin (Retinoic Acid)
|10.||Small Interfering RNA (siRNA)