Fibrin Tissue Adhesive (Fibrin Sealant)

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1379 relevant articles (156 outcomes, 191 trials/studies) found for this Bio-Agent

Description: An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.

Also Known As:

Fibrin Sealant; Beriplast; Crosseal; Fibrin Klebe System Immuno; Fibrin Seal; Fibrin Sealant, Human; Tisseel; Tissel; Tissucol; Transglutine; Adhesive, Fibrin; Adhesive, Fibrin Tissue; Adhesive, Fibrinogen; Glue, Fibrin; Human Fibrin Sealant; Seal, Fibrin; Sealant System, Fibrin; Sealant, Fibrin; Sealant, Human Fibrin; Tissue Adhesive, Fibrin; Autologous Fibrin Tissue Adhesive; Fibrin Adhesive; Fibrin Glue; Fibrin Sealant System; Fibrinogen Adhesive

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58301

Blood Proteins: 3858

Fibrin: 6342

Fibrin Tissue Adhesive: 1379

Experts

1.	Li, Jieshou: 4 articles (09/2007 - 09/2005)
2.	Vaiman, Michael: 4 articles (07/2006 - 06/2002)
3.	Morey, Allen F: 4 articles (01/2004 - 04/2002)
4.	Bahar, Irit: 3 articles (12/2007 - 12/2006)
5.	Olmi, Stefano: 3 articles (11/2007 - 11/2005)
6.	Croce, Enrico: 3 articles (11/2007 - 11/2005)
7.	Scaini, Alberto: 3 articles (11/2007 - 11/2005)
8.	Eviatar, Efraim: 3 articles (06/2004 - 06/2002)
9.	Segal, Samuel: 3 articles (06/2004 - 06/2002)
10.	Redl, H: 2 articles (10/2008 - 12/2000)

Related Diseases

1.	Hemorrhage 02/01/1989 - "This study shows that fibrin sealant is safe and highly effective in controlling localized bleeding in cardiac operations. " 08/01/2003 - "CONCLUSIONS: These results show that Beriplast is a safe and simple endoscopic treatment option and is very effective in controlling gastric variceal bleeding." 04/01/1999 - "CONCLUSION: These results demonstrate the high degree of efficacy of fibrin sealant delivered through a sheath system in plugging liver biopsy tracts and eliminating bleeding in a severely coagulopathic animal model. " 02/01/1995 - "Autologous fibrin tissue adhesive is beneficial in endoscopic sinus surgery, and its application should be considered, especially when the risk of hemorrhage or synechia is increased." 01/01/1995 - "Results in eight heparinized dogs (activated clotting time 374 +/- 22, mean +/- SEM) revealed a statistically significant reduction in signs of gross bleeding in the fibrin sealant-treated groins (1 versus 8, P = .016). " Order ALL the reference details at left...
2.	Fistula 03/01/2001 - "Fibrin glue is simple and effective treatment for all anal fistulas with excellent functional results." 12/01/2008 - "Closing the bronchial stump with an appropriate technique and supporting it with fibrin glue were considered effective in preventing bronchopleural fistula development after pulmonary resection in high-risk patients." 12/01/2002 - "PURPOSE: Fibrin glue is a novel treatment for anal fistulas and possesses many advantages in the treatment of difficult high fistulas. " 01/01/2009 - "CONCLUSION: Administration of expanded ASCs (20 to 60 million cells) in combination with fibrin glue is an effective and safe treatment for complex perianal fistula and appears to achieve higher rates of healing than fibrin glue alone." 03/01/2001 - "The aim of this study was to determine if a new sphincter muscle-sparing technique that uses fibrin glue was effective in closing all types of anal fistulas. " Order ALL the reference details at left...
3.	Wounds and Injuries (Trauma) 04/01/1986 - "However, comparisons of the curve magnitudes indicated that there was a significantly greater reduction in wound size in the fibrin sealant treated group. " 05/01/1986 - "This study evaluated Fibrin Sealant (FS), a two-component biologic adhesive that is effective in establishing hemostasis, in 27 experimentally produced splenic injuries in five adult mongrel dogs. " 02/01/1991 - "To prevent postoperative cerebrospinal fluid leakage, the following procedures were very useful; 'blind sack closure' of the external auditory canal, careful closure of the Eustachian tube, use of the pedicled muscle flap from the temporal and the sternocleidomastoid muscle, use of fibrin glue at the time of the wound closure, and placement of preventive spinal drainage. " 05/01/1988 - "The authors believe that fibrin seal is an effective and safe hemostatic agent applicable to splenic parenchymal injuries, and that it promotes wound healing and suppresses adhesion formation." 01/01/1986 - "It was found that the Immuno fibrin adhesive is a very useful new material for tightening the tracheal wounds. " Order ALL the reference details at left...
4.	Burns 03/01/2006 - "To facilitate their topical use in infected partial-thickness burns, the efficacy of a mixture with fibrin glue in vitro and in vivo was tested. " 03/01/2001 - "A multicenter clinical trial to evaluate the topical hemostatic efficacy of fibrin sealant in burn patients." 10/01/2007 - "The use of fibrin sealant in burn operations." 03/01/2006 - "CONCLUSION: A mixture of an antimicrobial peptide and commercially available fibrin glue is capable of significantly reducing bacteria in infected partial thickness burns in vivo compared to controls." 01/01/2000 - "Our group developed a new application form, using a suspension of subconfluently cultivated keratinocytes in fibrin glue (keratinocyte-fibrin-glue-suspension = KFGS), which has successfully been used in burn patients. " Order ALL the reference details at left...
5.	Seroma 03/01/2006 - "The success rate for seroma resolution (100 percent) was significantly greater with fibrin sealant injection in study patients than with serial aspiration alone (23 percent) in control patients (p = 0.0077). " 10/01/1988 - "At necropsy on day 5, a significant reduction in the frequency of seroma was noted in the fibrin glue group. " 03/01/1997 - "We conclude that (1) the harvesting of the rat latissimus dorsi muscle is a reliable model for creating seromas, (2) fibrin sealant effectively prevents seroma formation when applied intraoperatively, (3) wound healing in the seroma rat model is improved with intraoperative fibrin sealant application, (4) closed injection of fibrin sealant for existing seromas cannot be recommended at this time, (5) virally deactivated fibrin sealant retains its hemostatic and adhesive properties, and (6) current clinical trials of virally deactivated fibrin sealant may facilitate its use in the United States." 03/01/2006 - "CONCLUSIONS: Percutaneous instillation of fibrin sealant may be an effective treatment for refractory donor-site seromas. " 03/01/2006 - "It was hypothesized that percutaneous instillation of fibrin sealant is effective for the postoperative treatment of refractory donor-site seromas. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Fibrin Tissue Adhesive (Fibrin Sealant)
2.	Thrombin
3.	Fibrinogen (Factor I)
4.	polidocanol (Laureth)
5.	Collagen
6.	Gelatin
7.	Prostaglandins A (PGA)
8.	tachocomb
9.	Epinephrine (Adrenaline)
10.	Aprotinin (Trasylol)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Sutures (Suture)
3.	Tonsillectomy
4.	Pleurodesis
5.	Absorbable Gelatin Sponge

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