|1.||Kitchen, Scott G: 2 articles (09/2014 - 06/2004)|
|2.||Zack, Jerome A: 2 articles (09/2014 - 06/2004)|
|3.||Calzado, Marco A: 2 articles (09/2010 - 03/2009)|
|4.||Muñoz, Eduardo: 2 articles (09/2010 - 03/2009)|
|5.||Liechti, Thomas: 1 article (01/2015)|
|6.||Trkola, Alexandra: 1 article (01/2015)|
|7.||Rehr, Manuela: 1 article (01/2015)|
|8.||Günthard, Huldrych F: 1 article (01/2015)|
|9.||Zimmermann, Kathrin: 1 article (01/2015)|
|10.||Haas, Anna: 1 article (01/2015)|
12/01/2006 - "To demonstrate that EGCG binds to the CD4 molecule at the gp120 attachment site and inhibits gp120 binding at physiologically relevant levels, thus establishing EGCG as a potential therapeutic treatment for HIV-1 infection. "
08/01/1988 - "Additional studies of HTLV-IV infection of Sup-T1 cells, which are exquisitely sensitive to cytopathic effects induced by HIV-1, demonstrated that HTLV-IV infection could occur in the absence of cytopathic effects and, remarkably, with minimal or no downmodulation of the CD4 molecule from the cell surface. "
01/15/2015 - "Consistent with these in vitro results we show that CD4(+) T cells isolated from HIV(+) individuals are covered with ICs, which at least partially contain gp120, and suggest that IC binding to CD4 receptors might contribute to the progressive decline of CD4(+) T cell function during HIV-1 infection. "
06/01/2014 - "Importantly, the aptamers selectively bound CD4 on human cells and disrupted the interaction of viral gp120 to CD4 receptors, which is a prerequisite step of HIV-1 infection. "
05/15/2013 - "To obtain a global view of the signaling events induced during HIV-1 entry, we conducted a quantitative phosphoproteomics screen of primary human CD4(+) T cells after infection with an HIV-1 strain that engages the receptors CD4 and CXCR4. "
|2.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
05/15/1987 - "Because the L3T4 antigen in mice is homologous to the Leu-3/T4 (CD4) antigen in humans, these findings suggest that treatment with CD4 MAb may be effective in people with systemic lupus erythematosus."
07/01/1989 - "Heterogeneity of the CD4 antigen epitopes has been occasionally reported in healthy subjects, in patients affected by autoimmune diseases, such as Graves' disease and systemic lupus erythematosus (SLE), and recently also in HIV-infected subjects. "
|3.||HIV Infections (HIV Infection)
09/01/2014 - "Our studies have identified a novel function for the CD4 molecule on peripheral monocytes in triggering macrophage development that has direct consequences for HIV infection."
09/01/1996 - "Several studies have suggested that the CD4 molecule, in addition to serving as the HIV receptor, may also be involved in postbinding events of HIV infection. "
09/01/2014 - "Other than allowing HIV infection, the role of the CD4 molecule on human monocytes or macrophages is not known. "
06/01/2010 - "In the case of HIV infection, SIR was basically attributed to downregulation of the CD4 receptors. "
05/01/2009 - "Trophoblasts and villi have CD4 receptors, which make them potential candidates for HIV infection. "
|4.||Acquired Immunodeficiency Syndrome (AIDS)
03/05/1991 - "A soluble, recombinant CD4 molecule (rCD4), produced by expression of a truncated CD4 gene in Chinese hamster ovary (CHO) cells [Smith et al. (1987) Science 238, 1704-1707], is in clinical trials as a potential therapeutic agent in the treatment of acquired immunodeficiency syndrome (AIDS). "
10/01/1999 - "Since HIV also infects T-cells via the CD4 molecule, the interactions of these viruses within T-cells during the course of AIDS are important areas of investigation."
02/01/1995 - "Although 13 years have passed since identification of human immunodeficiency virus-1 (HIV-1) as the cause of AIDS, we do not yet know how HIV kills its primary target, the T cell that carries the CD4 antigen. "
01/01/1992 - "In AIDS a complementary interface between the HIV virus and the CD4 molecule of the T4 lymphocyte suggest a possible cause of immune self-recognition. "
06/01/1991 - "Since the CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV), it has been suggested that a soluble truncated form of CD4 may compete with cell-surface CD4 for HIV binding and thus be of use in the therapy of AIDS. "
01/01/1995 - "It is suggested that IAP may play a role in cancer-related immunosuppression through the down-modulation of the CD4 antigen on the lymphocyte surface."
01/01/1995 - "The modulation of the CD4 antigen by IAP on the lymphocyte surface was correlated with an increment of serum IAP levels in cancer patients. "
01/01/1995 - "This CD4 antigen modulation by IAP was observed in PBLs freshly isolated from patients with unresectable cancer but not in those isolated from patients with resectable tumor or from healthy volunteers. "
01/01/1988 - "Fluorescence-activated cell sorter (FACS) analysis of primary and transplantable lymphomas revealed cells of the T-cell lineage, with tumor cells expressing both OX-8 (CD8) and W3/25 (CD4) antigens. "
07/01/1994 - "These relatively large numbers of DC progeny should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors."
|3.||CD4 Antigens (CD4 Antigen)
|4.||IgE Receptors (Fc epsilon RI)
|5.||Indicators and Reagents (Reagents)
|7.||DNA (Deoxyribonucleic Acid)
|8.||monoclonal antibody 13B8-2
|9.||immune RNA (I-RNA)
|1.||Highly Active Antiretroviral Therapy (HAART)