Oncogene Protein pp60(v-src) (pp60 v-src)
A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine.
Also Known As:
pp60 v-src; Avian Sarcoma Virus-Transforming Protein; Oncogene Protein src; Phosphoprotein pp60(v-src); Rous Sarcoma Virus-Transforming Protein pp60(v-src); p60(v-src); src Oncogene Product pp60; v-src Protein; Avian Sarcoma Virus Transforming Protein; Protein pp60, v-src; Protein src, Oncogene; pp60 v src; pp60, v-src Protein; src, Oncogene Protein; v src Protein; v src Protein pp60; v-src, pp60; Oncogene Protein pp60(src); pp60(v-src); src Oncogene Protein pp60; v-src Protein pp60; Kinase (phosphorylating), protein pp60src
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Bio-Agent Context: Research Results
|1. ||Neoplasms (Cancer)
- "Transplantation resistance to a Rous sarcoma virus-induced tumor in mice immunized with v-src protein.
- "In the voluminous Hsp90 clientele, a large variety of important regulatory proteins can be identified, including many whose deregulation may lead to cancer initiation and progression, such as the oncogenic clients pp60(v-src), Bcr-Abl, mutated p53, ErbB2 (Her-2), Akt, Flt3, HIF-1alpha and B-Raf.
- "However, cells from a v-src-induced tumor expressed v-src RNA, and antibody to v-src protein precipitated from the tumor cells a 60,000-molecular-weight protein which displayed protein kinase activity.
|4. ||Breast Neoplasms (Breast Cancer)
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