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Osteocalcin

Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Also Known As:
4-Carboxyglutamic Protein, Bone; Bone gamma-Carboxyglutamic Acid Protein; 4 Carboxyglutamic Protein, Bone; Bone 4-Carboxyglutamic Protein; Bone gamma Carboxyglutamic Acid Protein; Calcium Binding Protein, Vitamin K Dependent; Protein, Bone 4-Carboxyglutamic; Protein, Bone Gla; Vitamin K Dependent Bone Protein; Bone Gla Protein; Calcium-Binding Protein, Vitamin K-Dependent; Gla Protein, Bone; Vitamin K-Dependent Bone Protein; Osteocalcin (human reduced), 3-de-L-tyrosine-4-de-L-glutamine-5-de-L-tryptophan-6-de-L-leucine-9-L-serine-12-L-serine-19-L-threonine-22-L-glutamine-28-L-alanine-33-L-serine-35-L-glutamine-36-L-tyrosine-38-L-leucine-39-L-lysine-40-L-threonine-43-L-lysine-45-L-isoleucine-48-L-isoleucine-49-L-threonine-49a-L-isoleucine-
Networked: 2238 relevant articles (45 outcomes, 253 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Terpos, Evangelos: 14 articles (01/2014 - 01/2003)
2. Inaba, Masaaki: 11 articles (03/2015 - 02/2005)
3. Karsenty, Gerard: 11 articles (05/2014 - 08/2007)
4. Ishimura, Eiji: 10 articles (03/2015 - 02/2005)
5. Ferron, Mathieu: 10 articles (11/2014 - 08/2007)
6. Nishizawa, Yoshiki: 10 articles (01/2014 - 01/2003)
7. Garnero, P: 10 articles (03/2009 - 02/2000)
8. Iwamoto, Jun: 9 articles (09/2012 - 09/2003)
9. Okuno, Senji: 8 articles (03/2015 - 05/2005)
10. Garnero, Patrick: 8 articles (01/2012 - 07/2004)

Related Diseases

1. Bone Resorption
2. Osteoporosis
3. Neoplasm Metastasis (Metastasis)
4. Body Weight (Weight, Body)
5. Weight Loss (Weight Reduction)

Related Drugs and Biologics

1. Alkaline Phosphatase
2. Biological Markers (Surrogate Marker)
3. deoxypyridinoline
4. Calcium
5. Parathyroid Hormone (Parathormone)
6. Insulin (Novolin)
7. Collagen Type I (Type I Collagen)
8. pyridinoline
9. collagen type I trimeric cross-linked peptide
10. Hydroxyproline (4 Hydroxyproline)

Related Therapies and Procedures

1. Injections
2. Continuous Ambulatory Peritoneal Dialysis (CAPD)
3. Peritoneal Dialysis
4. Aftercare (After-Treatment)
5. Renal Dialysis (Hemodialysis)