1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)

Subscribe to Selected New Research on 1-Methyl-4-phenylpyridinium

185 relevant articles (7 outcomes, 17 trials/studies) found for this Bio-Agent

Description: An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

Also Known As:

1 Methyl 4 phenylpyridinium; 1-Methyl-4-phenylpyridine; 1-Methyl-4-phenylpyridinium Chloride; 1-Methyl-4-phenylpyridinium Ion; N-Methyl-4-phenylpyridine; N-Methyl-4-phenylpyridinium; 1 Methyl 4 phenylpyridine; 1 Methyl 4 phenylpyridinium Chloride; 1 Methyl 4 phenylpyridinium Ion; N Methyl 4 phenylpyridine; Cyperquat; Pyridinium, 1-methyl-4-phenyl-

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Pyridines: 26

Pyridinium Compounds: 4

1-Methyl-4-phenylpyridinium: 185

1-methyl-4-(2-methylphenyl)pyridinium

1-methyl-4-(4'-acetamidophenyl)pyridinium

1-methyl-4-cyclohexylpyridinium

Experts

1.	Soliman, Karam F A: 2 articles (03/2004 - 07/2003)
2.	Tsuji, Sadatoshi: 1 article (03/2008)
3.	Hashimoto, Tomoyo: 1 article (03/2008)
4.	Oyanagi, Kiyomitsu: 1 article (03/2008)
5.	Nishi, Katsunori: 1 article (03/2008)
6.	Nagasao, Jun: 1 article (03/2008)
7.	Zeevalk, Gail D: 1 article (01/2008)
8.	German, Dwight C: 1 article (01/2008)
9.	Sonsalla, Patricia K: 1 article (01/2008)
10.	Kim, Sun-Yee: 1 article (02/2007)

Related Diseases

1.	Neuroblastoma 02/01/2008 - "Cell-permeable Bcl-xL protected neuroblastoma cells from the selective neurotoxin 1-methyl-4-phenylpyridinium" 02/14/2007 - "SAG protects human neuroblastoma SH-SY5Y cells against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity via the downregulation of ROS generation and JNK signaling." 09/11/2006 - "The role of tissue transglutaminase in 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in differentiated human SH-SY5Y neuroblastoma cells." 01/21/2005 - "TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells." 03/15/2004 - "The effects of increasing mitochondrial oxidative phosphorylation (OXPHOS), by enhancing electron transport chain components, were evaluated on 1-methyl-4-phenylpyridinium (MPP+) toxicity in brain neuroblastoma cells" Order ALL the reference details at left...
2.	Parkinson Disease (Parkinson's Disease) 06/01/1995 - "The possibility of functional difference of these cells in Parkinson's disease led us study the effect of 1-methyl-4-phenylpyridinium (MPP+) on them" 01/01/2008 - "Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease." 12/01/2007 - "Cellular models of Parkinson's disease were produced by administering different concentrations of 1-methyl-4-phenylpyridinium to PC12 and SH-SY5Y cell lines" 12/01/2006 - "We showed that the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)), which produces features of Parkinson's disease in humans, was toxic for hESC-derived dopaminergic neurons" 07/01/2006 - "Rat model of Parkinson's disease: chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+)." Order ALL the reference details at left...
3.	Pheochromocytoma 01/01/1997 - "Changes of energy metabolism induced by 1-methyl-4-phenylpyridinium (MPP+)-related compounds in rat pheochromocytoma PC12 cells." 04/15/1988 - "Inhibition of aromatic L-aminoacid decarboxylase in clonal pheochromocytoma PC12h cells by N-methyl-4-phenylpyridinium ion (MPP+)." 09/01/2006 - "Objective To investigate the effects of 14-3-3 protein overexpression on the 1-methyl-4-phenylpyridinium (MPP(+)) induced pheochromocytoma (PC12) cell death and the potential mechanisms" 09/01/2006 - "Overexpression of 14-3-3 protein protects pheochromocytoma cells against 1-methyl-4-phenylpyridinium toxicity." 02/01/1995 - "When rat pheochromocytoma PC12 cells are cultured with 1 mM 1-methyl-4-phenylpyridinium (MPP+), the number of viable cells decreases to one third in 4 days while the number increases ten-fold without MPP+. Oxygen consumption by mitochondria in the presence of malate is inhibited about 80% by the treatment of the cells with MPP+ for 4 days" Order ALL the reference details at left...
4.	Parkinsonian Disorders (Parkinsonism) 01/01/2007 - "The neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) produces mitochondria-targeted injury, which contributes to parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine in mammals" 05/01/2005 - "The molecular mechanism of 1-methyl-4-phenylpyridinium (MPP+), a Parkinsonism-inducing neurotoxin, has been studied in PC12 cells" 11/07/2003 - "The mechanisms whereby 1-methyl-4-phenylpyridinium (MPP(+)) mediates cell death and Parkinsonism are still unclear" 01/01/2001 - "We analyzed the effect of this pathway on the action of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium (MPP+)" 11/01/1999 - "Similarly, the differentiated DA neurons were more sensitive to another neurotoxin, 1-methyl-4-phenylpyridinium (MPP+), which is commonly used to induce Parkinsonism in animal models, than were the undifferentiated DA neurons in culture" Order ALL the reference details at left...
5.	Necrosis 11/01/1994 - "We have investigated the mode of death induced by complex I inhibition of dopaminergic cell cultures, and our results suggest that both 1-methyl-4-phenylpyridinium and rotenone cause apoptosis at low concentrations and necrosis at high concentrations" 06/20/2008 - "In this study, we investigated the mechanisms underlying the neuroprotective effects of calbindin-D28K in staurosporine (STS)-induced apoptosis and 1-methyl-4-phenylpyridinium (MPP(+))-induced necrosis" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Oxidopamine (6 Hydroxydopamine)
2.	Hydrogen Peroxide (Hydroperoxide)
3.	Dopamine (Intropin)
4.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
5.	Monoamine Oxidase (MAO)
6.	Smoke
7.	Glutamic Acid (Glutamate)
8.	Cocaine (Cocaine HCl)
9.	Fullerenes
10.	Granulocyte Colony-Stimulating Factor (G-CSF)

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