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Pentostatin (Nipent)

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Also Known As:
Nipent; CI-825; Co-Vidarabine; Deoxycoformycin; Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-; NSC-218321; 2' Deoxycoformycin; CI 825; CI825; NSC 218321; NSC218321; 2'-Deoxycoformycin; Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
Networked: 512 relevant articles (64 outcomes, 90 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Grever, Michael R: 14 articles (01/2015 - 03/2003)
2. Kay, Neil E: 9 articles (01/2019 - 01/2004)
3. Byrd, John C: 8 articles (01/2015 - 04/2005)
4. Robak, Tadeusz: 7 articles (06/2021 - 03/2003)
5. Ravandi, Farhad: 7 articles (01/2020 - 01/2006)
6. Call, Timothy G: 6 articles (01/2018 - 01/2007)
7. Shanafelt, Tait D: 6 articles (01/2018 - 01/2007)
8. Vogelsang, Georgia B: 6 articles (11/2009 - 07/2003)
9. Pastan, Ira: 5 articles (01/2020 - 10/2009)
10. Hensel, Manfred: 5 articles (01/2015 - 05/2003)

Related Diseases

1. Hairy Cell Leukemia
2. Neoplasms (Cancer)
3. Leukemia
4. Lymphoma (Lymphomas)
5. Splenomegaly

Related Drugs and Biologics

1. Pentostatin (Nipent)
2. Cladribine
3. Adenosine Deaminase
4. Interferon-alpha (Interferon Alfa)
5. Rituximab (Mabthera)
6. purine
7. Nucleosides
8. Cyclophosphamide (Cytoxan)
9. Interferons
10. 2'-deoxyadenosine

Related Therapies and Procedures

1. Therapeutics
2. Splenectomy
3. Drug Therapy (Chemotherapy)
4. Aftercare (After-Treatment)
5. Intravenous Administration