Cytochalasin D

A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.

Also Known As:

Networked: 250 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yan, Jie: 3 articles (01/2021 - 08/2006)
2.	Shukla, Deepak: 3 articles (01/2013 - 08/2008)
3.	Tiwari, Vaibhav: 3 articles (01/2013 - 08/2008)
4.	Buhrmann, Constanze: 2 articles (01/2021 - 09/2017)
5.	Shakibaei, Mehdi: 2 articles (01/2021 - 09/2017)
6.	Hass, Ralf: 2 articles (02/2019 - 05/2015)
7.	An, Jing: 2 articles (05/2016 - 08/2010)
8.	Gao, Na: 2 articles (05/2016 - 08/2010)
9.	Dai, Hao-Fu: 2 articles (07/2013 - 03/2012)
10.	Huang, Feng-Ying: 2 articles (07/2013 - 03/2012)

Related Diseases

1.	Infections 01/01/2021 - "Surprisingly, blocking phagocytosis by cytochalasin D treatment did not affect mosquito susceptibility to Sm infections established through either route. " 01/01/2016 - "incognita infection affected the structure of cells in cucumber roots and treatment of the cytoskeleton inhibitor (cytochalasin D) reduced root-knot nematode (RKN) parasitism. " 01/01/2015 - "aureus by suppressing the phagocytic activity of macrophages with cytochalasin D before infection was investigated. " 03/01/2014 - "Disruption of actin filaments by cell treatment with cytochalasin D resulted in a successful second infection. " 02/01/2010 - "Here, we challenge this hypothesis by quantifying Encephalitozoon cuniculi infection rates of J774 cells that were incubated with the phagocytosis inhibitor cytochalasin D. "
2.	Anaphylaxis (Anaphylactic Shock) 08/01/1997 - "Our studies provide evidence that cytochalasin D will be beneficial in the treatment of anaphylaxis." 08/01/1997 - "We investigated the effect of cytochalasin D on anaphylaxis. " 08/01/1997 - "Effect of cytochalasin D on systemic and local anaphylaxis in a murine model." 07/01/1995 - "Suppression of anaphylactic shock in sensitized guinea pigs by cytochalasin D." 08/01/1997 - "Cytochalasin D (10(-1) microg g-1 BW) also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE to 79.6+/-1.8%. "
3.	Hyperplasia 10/01/2001 - "Although perivascular infusion of cytochalasin D inhibited collar-induced SMC migration from media to intima in vivo as well, the intimal hyperplasia was not reduced due to concomitant development of an inflammatory response." 10/01/2001 - "Therefore, we investigated whether cytochalasin D, a fungal metabolite that inhibits actin filament formation, suppressed SMC migration and collar-induced intimal hyperplasia in the rabbit carotid artery. " 10/01/2001 - "Effects of local cytochalasin D delivery on smooth muscle cell migration and on collar-induced intimal hyperplasia in the rabbit carotid artery." 02/01/2006 - "Effects of cytochalasin D-eluting stents on intimal hyperplasia in a porcine coronary artery model." 12/01/2003 - "Local cytochalasin D delivery from this stent-platform significantly inhibits neointimal hyperplasia in a porcine coronary model."
4.	Pemphigus (Pemphigus Vulgaris) 09/01/2010 - "Therefore, we investigated whether pharmacological manipulation of actin polymerization modulates pathogenic effects of PV-IgG. Pharmacological stabilization of actin filaments via jasplakinolide significantly blocked cell dissociation and Dsg3 fragmentation, whereas cytochalasin D-induced actin depolymerization strongly enhanced pathogenic effects of PV-IgG. To substantiate these findings, we studied whether the protective effects of Rho GTPases, which are potent regulators of the actin cytoskeleton and were shown to be involved in pemphigus pathogenesis, were dependent on modulation of actin dynamics. "
5.	Glioma (Gliomas) 01/01/2017 - "Treatment with cytochalasin D, an actin polymerization inhibitor, significantly reduced the FMOD-induced glioma cell migration. " 09/29/2014 - "Our data shows that cytochalasin D compromises the spreading area of single glioma cells, eventually decreasing their 'inside-out' contractile forces, and 'outside-in' force response to external strain. " 09/29/2014 - "Using a highly aggressive glioma model (DBTRG-05MG), we present a platform technology to quantify single cell force modulation (both inside-out and outside-in) with and without the presence of a cytoskeleton altering drug (cytochalasin D) using suspended and aligned fiber networks (nanonets) beginning to represent the aligned glioma environment. " 07/14/2004 - "At the distal end of C6 glioma cell processes, GLT-1 clusters undergo rapid morphological changes in both shape and size, and these changes are inhibited by cytochalasin D treatment, suggesting that the morphogenesis of GLT-1 clusters is highly dependent on the actin network. " 04/24/1997 - "In the present study, cytochalasin D (CD) and calmodulin antagonists were used to examine the influence of F-actin and calmodulin on membrane interaction of MARCKS in C6 glioma cells. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	jasplakinolide
3.	Immunoglobulin G (IgG)
4.	rho GTP-Binding Proteins (rho GTP-Binding Protein)
5.	Viral RNA
6.	Colchicine
7.	Actins (F Actin)
8.	Nocodazole
9.	latrunculin A (LAT-A)
10.	Phalloidine

Related Therapies and Procedures

1.	Stents
2.	Therapeutics
3.	Intraocular Injections
4.	Punctures
5.	Microspheres (Microsphere)