Choledochal Cyst (Choledochal Cysts)

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265 relevant articles (4 outcomes, 11 trials/studies) found for this Disease

Description: A congenital anatomic malformation of a bile duct, including cystic dilatation of the extrahepatic bile duct or the large intrahepatic bile duct. Classification is based on the site and type of dilatation. Type I is most common.

Also Known As:

Choledochal Cysts; Choledochal Cyst, Diverticulum; Choledochal Cyst, Type II; Choledochal Cyst, Type III; Choledochal Cyst, Type IV; Choledochal Cyst, Type V; Choledochal Diverticulum; Choledochocele; Cyst, Common Bile Duct; Cysts, Common Bile Duct; Intrahepatic Choledochal Cyst; Multiple Choledochal Cysts; Choledochal Cyst, Intrahepatic; Choledochal Cysts, Diverticulum; Choledochal Cysts, Intrahepatic; Choledochoceles; Diverticulum Choledochal Cyst; Diverticulum Choledochal Cysts; Intrahepatic Choledochal Cysts; Choledochal Cyst, Type I; Common Bile Duct Cyst

Relationship Network

Disease Context: Research Results

Neoplasms: 415397

Cysts: 12160

Choledochal Cyst: 265

Digestive System Diseases: 31

Biliary Tract Diseases: 308

Bile Duct Diseases: 39

Choledochal Cyst: 265

Caroli Disease: 92

Digestive System Abnormalities

Choledochal Cyst: 265

Caroli Disease: 92

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 449

Congenital Abnormalities: 10008

Digestive System Abnormalities

Choledochal Cyst: 265

Caroli Disease: 92

Related Diseases

1.	Cysts
2.	Pathologic Constriction (Stenosis)
3.	Wounds and Injuries (Trauma)
4.	Biliary Atresia
5.	Hepatitis

Experts

1.	Yamataka, Atsuyuki: 3 articles (01/2005 - 12/2003)
2.	Kobayashi, Hiroyuki: 3 articles (01/2005 - 12/2003)
3.	Miyano, Takeshi: 3 articles (01/2005 - 12/2003)
4.	Ando, Hisami: 2 articles (03/2008 - 11/2004)
5.	Kaneko, Kenitiro: 2 articles (03/2008 - 11/2004)
6.	Okada, Yasuhiro: 2 articles (04/2007 - 12/2003)
7.	Lane, Geoffrey J: 2 articles (01/2005 - 12/2003)
8.	Shimotakahara, Akihiro: 2 articles (01/2005 - 12/2003)
9.	Yanai, Toshihiro: 2 articles (01/2004 - 12/2003)
10.	Lovvorn, Harold N: 1 article (07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Choledochal Cyst:

1.	AmylasesIBA 05/01/1983 - "Increased renal clearance of amylase in fusiform choledochal cyst--a report of 2 cases." 03/01/1990 - "Pseudopancreatitis in choledochal cyst in children: intraoperative study of amylase levels in the serum." 04/07/2005 - "AIM: To investigate the relationship between pancreatic amylase in bile duct and the clinico-pathological features in adult patients with choledochal cyst and anomalous pancreatico-biliary ductal union (APBDU). " 04/07/2005 - "Amylase level in extrahepatic bile duct in adult patients with choledochal cyst plus anomalous pancreatico-biliary ductal union." 04/01/2005 - "The rate of abnormal elevation of amylase level in the bile in the two types of pancreatobiliary ductal system and choledochocele was 3/7 and 1/1, respectively. " Order ALL the reference details at left...
2.	Messenger RNA (mRNA)IBA 11/01/2008 - "Liver tissues were obtained from 10 patients with early and late stage of BA, 10 patients with choledochal cyst, and 4 normal controls to study upstream stimulatory factor 2 (USF2) messenger RNA (mRNA) and protein expressions. " 07/01/2004 - "Frozen liver tissue obtained from patients with biliary atresia, neonatal giant cell hepatitis, total parenteral nutrition (TPN)-related cholestasis, choledochal cysts, and normal control subjects was used for fluorescent immunohistochemistry studies of cellular infiltrates, cytokine mRNA expression, and in situ hybridization for localization of cytokine-producing cells. " 11/01/2000 - "METHODS: Immunohistochemical stains of Fas and Fas ligand (FasL) and in situ hybridization of Fas ligand messenger RNA (mRNA) were performed on paraffin-embedded liver specimens of 36 biliary atresia, 6 choledochal cysts, and 14 nontumorous parts of pediatric liver tumors. " Order ALL the reference details at left...
3.	phytobacteriomycin (PBM)IBA 07/01/2001 - "BACKGROUND AND STUDY AIMS: Choledochocele has a potential for carcinogenesis, but no report has described malignant changes of the choledochocele in relation to pancreaticobiliary reflux because its anatomic form does not fit the criteria of pancreaticobiliary malunion (PBM). " 01/01/2009 - "But, PBM is an independent disease entity from choledochal cyst. " 01/01/2009 - "BACKGROUND: It is widely accepted that congenital choledochal cyst is associated with pancreaticobiliary maljunction (PBM). " 01/01/2004 - "Since MRCP is noninvasive and requires neither radiation exposure nor a contrast agent, and is useful for detecting both anastomosis and pancreatico-biliary ducts around PBM, MRCP might be superior to IVC-SCT as an imaging technique for outpatient clinics performing long-term follow-up studies in children with choledochal cysts." 04/01/2003 - "BACKGROUND: Pancreaticobiliary maljunction (PBM) is frequently associated with congenital choledochal cyst (CCBD), but differs in embryonic cause and clinical features. " Order ALL the reference details at left...
4.	EnzymesIBA 02/01/2001 - "The pathophysiology of choledochal cysts remains unclear, although an association with anomalous pancreato-biliary junction and the reflux of pancreatic enzymes into the biliary tree is known. " 06/01/1995 - "Choledochal cyst is commonly associated with pancreatobiliary maljunction, and high concentrations of pancreatic enzymes in bile are usually observed. " 12/01/1994 - "This disputes the traditional hypothesis of reflux of pancreatic enzymes and supports the recent theory of primary obstruction as the etiologic cause of choledochal cyst. " 07/01/1989 - "Pancreatic enzymes in the bile of congenital choledochal cyst with anomalous pancreaticobiliary ductal union were analyzed. " 07/01/1989 - "[Analysis of pancreatic enzymes in the bile of congenital choledochal cyst with anomalous pancreaticobiliary ductal union]" Order ALL the reference details at left...
5.	Carbon MonoxideIBA 12/31/2006 - "The purpose of this study was to investigate and discuss imaging methods and management strategies for congenital choledochal cyst with co-existing intrahepatic dilation and aberrant bile duct as well as other complicated biliary anomalies. " 12/31/2006 - "Management strategy for congenital choledochal cyst with co-existing intrahepatic dilation and aberrant bile duct as well as other complicated biliary anomalies." 06/01/1998 - "Co-existing biliary anomalies and anatomical variants in choledochal cyst." 01/01/2009 - "We are presenting a case in which choledochal cyst co-existed with biliary atresia; the antenatal diagnosis was that of choledochal cyst. " 01/01/1997 - "A 29-year-old nulliparous woman at 32nd week gestation was diagnosed as acute pancreatitis with co-existing type l choledochal cyst. " Order ALL the reference details at left...
6.	Bile Acids and Salts (Bile Acids)IBA 08/01/1990 - "These data suggest that stasis of bile within choledochal cysts contributes to bacterial overgrowth and generation of unconjugated secondary bile acids." 08/01/1990 - "Increased secondary bile acids in a choledochal cyst. " 02/01/1993 - "The results suggest that the factor other than secondary bile acids can be primarily responsible for the high risk of bile duct carcinoma in patients with choledochal cyst." 02/01/1993 - "Are secondary bile acids in choledochal cysts important as a risk factor in biliary tract carcinoma?" 02/01/1993 - "Since secondary bile acids have mutagenic potency and choledochal cyst patients with or without cyst-enterostomy have a high risk of developing bile duct carcinoma, we examined the hypothesis that secondary bile acids are elevated in the choledochal cyst and possibly cause biliary tract carcinoma. " Order ALL the reference details at left...
7.	chenodeoxycholate sulfate conjugate (CDCS)IBA 10/01/2006 - "The purpose of this analysis is to study the clinical features, liver histology and the outcome after surgery in infants with choledochal cysts (CDCs), and to draw conclusions on the management strategy accordingly. " 07/01/2009 - "Choledochal cysts (CDCs) identified during the prenatal or immediate postnatal period are unusual with a majority being identified in older children and adults. " 01/01/2007 - "OBJECTIVES: The presentation of choledochal cysts (CDCs) is altered by complications such as acute severe cholangitis, hepatolithiasis, spontaneous perforation, portal hypertension, pancreatitis, malignancy of the biliary tract and previous surgery in the form of internal drainage of the cyst. " Order ALL the reference details at left...
8.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 02/01/2004 - "This study was to assess the relationship between the expression of inducible nitric oxide synthase (iNOS) and the p53 gene as well as the pathogenesis of choledochal cysts. " 02/01/2004 - "Expressions of p53 and inducible nitric oxide synthase in congenital choledochal cysts." Order ALL the reference details at left...
9.	Secretin FDA Link 10/01/2006 - "Dynamic study of pancreaticobiliary reflux using secretin-stimulated magnetic resonance cholangiopancreatography in patients with choledochal cysts." Order ALL the reference details at left...
10.	Bile Pigments (Bilin)IBA 10/01/2009 - "Recently, a large interobserver agreement study in patients with hepatolithiasis, choledochal cysts, and primary sclerosing cholangitis proposed diagnostic criteria for 3 categories of BilIN based on increasing grades of nuclear atypia and loss of nuclear polarity: BilIN-1, BilIN-2, and BilIN-3. " Order ALL the reference details at left...

Therapies and Procedures

1.	Endoscopic Sphincterotomy 02/01/2007 - "Endoscopic sphincterotomy is feasible and effectively treats both lesions even in larger choledochoceles." 01/01/1998 - "Small choledochoceles can be safely managed by endoscopic sphincterotomy." 01/01/1997 - "Additionally, in selected cases, a choledochocele may be effectively managed by endoscopic sphincterotomy. " 01/01/1996 - "In 6 patients with symptomatic or questionably symptomatic choledochoceles, endoscopic treatment in the form of endoscopic papillotomy was carried out. " 03/01/1994 - "Two patients, each with a small choledochocele, were treated successfully by endoscopic sphincterotomy and stone extraction. " Order ALL the reference details at left...
2.	Liver Transplantation 07/01/2008 - "METHODS: Plasma levels of HGF were determined using an enzyme-linked immunosorbent assay from 19 patients with BA, 10 at the time of Kasai procedure (KP) and 9 at liver transplantation (LT), and 10 patients with nonicteric choledochal cyst served as control. " 09/01/2007 - "METHODS: Hepatic immunoreactive 8-OHdG expression was investigated during the early stage of BA when the patients received Kasai portoenterostomy (KP), during the late stage when the patients received liver transplantation (LT), in patients with choledochal cyst as disease control, and in patients with histologically normal liver as normal control. " 08/15/2001 - "Living donor with type IV-A choledochal cyst in liver transplantation." 10/01/2008 - "New features, hitherto not reported, were vaginal atresia, a type 1 choledochal cyst and, owing to the progressive nature of the liver disease, the need for liver transplantation. " 12/01/1992 - "The authors describe a case of orthotopic liver transplantation (OLT) in a patient with an infantile form of choledochal cyst that progressed to severe hepatic failure. " Order ALL the reference details at left...
3.	Laparoscopes (Laparoscope) 10/01/1999 - "Laparoscope-assisted minimally invasive treatment for choledochal cyst." 09/07/2004 - "CONCLUSIONS: Total cyst excision with Roux-en-Y hepatoenterostomy by ultrasonic scalpel under the laparoscope was effective and safe for choledochal cyst. " 09/07/2004 - "[Total cyst excision with ultrasonic scalpel under the laparoscope for choledochal cyst.]" Order ALL the reference details at left...
4.	Jejunostomy 10/15/2004 - "In the second patient, 4 wk after percutaneous trans-choledochal cyst was drained externally with a catheter under US guidance, four weeks later the patient delivered vaginally, and had a cysto-jejunostomy 3 mo after delivery, and lived well without any complications for 15 years after operation. " 12/01/2003 - "Recommendations for preventing complications related to Roux-en-Y hepatico-jejunostomy performed during excision of choledochal cyst in children." 05/01/2001 - "Resection of the diseased common bile duct and Roux-Y hepatico-jejunostomy are the method of choice in the treatment of children with choledochal cyst." 11/01/1997 - "Cholescintigraphy in the evaluation of bile flow after Roux-en-Y hepatico-jejunostomy and hepatico-antrostomy in infants with choledochal cysts." 10/01/1996 - "So, excision of the choledochal cyst and a Roux-en-Y porto-jejunostomy was done. " Order ALL the reference details at left...
5.	Total Parenteral Nutrition 01/01/2004 - "The biliary tree was completely opacified in 5 infants with the following diagnosis: neonatal hepatitis (2), duplication of the gallbladder (1), choledochocele (1), total parenteral nutrition (TPN) cholestasis (1). " 08/01/1994 - "Controls consisted of five patients with various conditions including total parenteral nutrition-induced cholestasis, choledochal cyst, viral hepatitis, metastatic carcinoma, and thrombotic thrombocytopenic purpura. " 11/01/2005 - "The etiologies of cholestasis were idiopathic neonatal hepatitis (INH) 23%, extrahepatic biliary atresia (EHBA) 22.2%, total parenteral nutrition (TPN)-related cholestasis 18.3%, infection 9.9%, endocrine causes 6%, choledochal cyst 5.6%, Down syndrome 4.4%, hemolytic anemia 1.6%, and miscellaneous causes 9.1%, respectively. " 07/01/2004 - "Frozen liver tissue obtained from patients with biliary atresia, neonatal giant cell hepatitis, total parenteral nutrition (TPN)-related cholestasis, choledochal cysts, and normal control subjects was used for fluorescent immunohistochemistry studies of cellular infiltrates, cytokine mRNA expression, and in situ hybridization for localization of cytokine-producing cells. " 01/01/1997 - "To compare the diagnostic utility of these two modalities, 66 patients with neonatal cholestasis (15 BA, 3 choledochal cyst (CC), 32 neonatal hepatitis, 13 prolonged jaundice, 2 total parenteral nutrition, and 1 sepsis) underwent Tc-99m disofenin CS and US. " Order ALL the reference details at left...

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