AIDS Dementia Complex

354  relevant articles (24 outcomes, 33 trials/studies) found for this Disease

AIDS-Related Dementia Complex; Acquired-Immune Deficiency Syndrome Dementia Complex; Dementia Complex, Acquired Immune Deficiency Syndrome; Encephalopathy, AIDS; Encephalopathy, HIV; HIV-1 Cognitive and Motor Complex; AIDS Encephalopathies; AIDS Related Dementia Complex; Complex, AIDS Dementia; Complex, AIDS-Related Dementia; Dementia Complex, AIDS; Dementia Complex, AIDS Related; Dementia, HIV; Dementias, HIV; Encephalopathies, AIDS; Encephalopathies, HIV; HIV 1 Associated Cognitive Motor Complex; HIV 1 Cognitive and Motor Complex; HIV Associated Cognitive Motor Complex; HIV Dementias; HIV Encephalopathies; AIDS Encephalopathy; Dementia Complex, AIDS-Related; HIV Dementia; HIV Encephalopathy; HIV-1-Associated Cognitive Motor Complex; HIV-Associated Cognitive Motor Complex

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS)
2.	Infection
3.	Parkinson Disease (Parkinson's Disease)
4.	Opportunistic Infections (Opportunistic Infection)
5.	Encephalitis (Encephalitis, Rasmussen)

Experts

1.	Brew, Bruce J: 7 articles (06/2007 - 07/2003)
2.	Price, Richard W: 6 articles (06/2007 - 10/2002)
3.	Nath, A: 3 articles (05/2008 - 02/2001)
4.	Sacktor, N: 3 articles (05/2008 - 04/2001)
5.	Nath, Avindra: 3 articles (09/2007 - 06/2003)
6.	Hagberg, Lars: 3 articles (06/2007 - 05/2004)
7.	McArthur, J: 2 articles (05/2008 - 04/2001)
8.	Gisslen, Magnus: 2 articles (06/2007 - 05/2004)
9.	Cinque, Paola: 2 articles (06/2007 - 05/2004)
10.	Rosengren, Lars: 2 articles (06/2007 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to AIDS Dementia Complex:

1.	Zidovudine (Retrovir)FDA LinkGeneric 11/01/1994 - "(2) In the absence of clear guideline, the efficacy of zidovudine in the AIDS dementia complex has been demonstrated. " 11/30/1992 - "[AIDS encephalopathy--helped by azidothymidine? " 01/01/1996 - "The aim of the study was to describe the epidemiology of AIDS dementia complex (ADC) in Europe and to assess the possible role of zidovudine therapy in preventing or delaying its occurrence. " 04/01/1993 - "Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. " 05/01/1989 - "Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine): a PET-FDG study." Order ALL the reference details at left...
2.	Anti-Retroviral Agents (Antiretroviral Agents)IBA 02/01/2008 - "The use of antiretroviral agents has led to a decrease in the incidence of HIV dementia but the prevalence of milder forms of neurocognitive impairment has increased. " 07/01/1997 - "Antiretroviral agents are the only proven therapies currently used for the treatment of HIV dementia, but the response to these agents is frequently unsatisfactory, short-lived, or complicated by intolerable side effects. " 10/01/1994 - "CONCLUSION: Despite the earlier and more widespread use of antimicrobial and antiretroviral agents, neurologic conditions still occurred frequently in this cohort, with annual rates above 1.5 per 100 person-years for HIV dementia and sensory neuropathy. " 10/01/1994 - "We noted a protective trend of antimicrobial prophylaxis on toxoplasmosis and cryptococcal meningitis, but, in contrast, use of antiretroviral agents was not protective against HIV dementia. " 01/01/1995 - "Zidovudine is effective in preventing the onset of AIDS-dementia complex but little is known about the efficacy of other antiretroviral agents. " Order ALL the reference details at left...
3.	abacavir (Ziagen)FDA Link 01/01/2007 - "OBJECTIVES: To determine the efficacy of adding abacavir (Ziagen, ABC) to optimal stable background antiretroviral therapy (SBG) to AIDS dementia complex (ADC) patients and address trial design. " 01/01/2007 - "Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial." 12/01/2006 - "Abacavir (ABC) achieves good CSF concentrations and studies of high-dose ABC showed benefit in adults with HIV dementia. " 11/07/1997 - "Glaxo Wellcome is broadening the entry criteria for its experimental antiretroviral drug 1592 (abacavir) for persons with AIDS dementia complex (ADC). " 04/13/2001 - "HIV-1 reverse transcriptase sequence in plasma and cerebrospinal fluid of patients with AIDS dementia complex treated with Abacavir." Order ALL the reference details at left...
4.	RNA (Ribonucleic Acid)IBA 01/01/2006 - "Elevated cerebrospinal fluid (CSF) levels of markers of neural injury and immune activation have been found in HIV dementia, but neither of those, nor CSF HIV-1 RNA levels have been proven useful as diagnostic or prognostic pseudomarkers in HIV dementia. " 01/01/2005 - "CSF HIV RNA correlated neither with the severity of the AIDS dementia complex (ADC) nor abnormal quantitative neurological performance, although these measures were associated with depression of CD4 counts. " 11/01/1997 - "Cerebrospinal fluid (CSF) human immunodeficiency virus (HIV) RNA levels were measured with the Nucleic Acid Sequence-Based Amplification (NASBA) assay to determine the relationship with neurological status; 37 subjects with HIV dementia (HIV-D) were compared with 77 with HIV with minor neurological signs (HIV-MCMD) and 93 neurologically normal HIV-seropositive individuals (HIV-NML). " 04/01/1997 - "The relationship between the presence and severity of AIDS dementia complex (ADC) and the levels of human immunodeficiency virus type 1 (HIV-1) RNA in cerebrospinal fluid (CSF) were assessed. " 11/07/1986 - "Using in situ hybridization, we examined brain tissue from two patients with AIDS encephalopathy for the presence of HTLV-III RNA. " Order ALL the reference details at left...
5.	Protons (Proton)IBA 01/01/2007 - "Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity." 04/01/2005 - "PURPOSE: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. " 01/01/1999 - "METHODS: A total of 54 patients with HIV-CMC (20 with HIV-MCMD, 34 with HIV-dementia) and 29 seronegative healthy volunteers were evaluated for cerebral metabolite abnormalities using proton (1H) MRS in the frontal cortex, frontal white matter, and basal ganglia. " 08/10/1997 - "We have examined 112 HIV patients--35 neuroasymptomatic patients and 77 patients with ADC (AIDS dementia complex)--with localized proton MRS, using the PRESS 135-msec sequence. " 05/01/1996 - "CONCLUSION: Proton MR spectroscopy may be a more sensitive diagnostic technique than MR imaging in childhood AIDS encephalopathy." Order ALL the reference details at left...
6.	N-acetylaspartate (N-acetyl aspartate)IBA 09/01/2003 - "To assess this extent, the relationship between global neuronal integrity, reflected by the whole-brain N-acetylaspartate (WBNAA) concentration, was correlated with neuropsychological function and the AIDS dementia complex (ADC) stage score. " 07/01/1993 - "N-acetyl aspartate (NAA) is believed to be a neuronal marker, and neuronal loss is thought to underlie the human immunodeficiency virus (HIV)-associated cognitive/motor complex. " 04/01/2005 - "Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. " 02/01/1998 - "Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy." 05/01/1995 - "It is concluded that N-acetyl aspartate/creatine ratios are reduced in childhood AIDS encephalopathy and proton magnetic resonance spectroscopy may be helpful in defining brain human immunodeficiency virus-1 infection. " Order ALL the reference details at left...
7.	N-Methylaspartate (NMDA)IBA 08/01/2008 - "N-methyl-D-aspartate (NMDA) receptor activation is involved in the pathogenetic cascades of neurodegenerative disorders including human immunodeficiency virus (HIV) dementia. " 05/01/1990 - "Particular interest has gained the possible neuroprotective efficacy of NMDA-receptor antagonists in neurological diseases such as hypoxia/ischemia, hypoglycemia, epilepsy and chronic neurodegenerative disorders (Huntington's, Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, and AIDS encephalopathy).(ABSTRACT TRUNCATED AT 250 WORDS)" 10/06/2006 - "Interleukin-1beta is a proinflammatory cytokine implicated under pathological conditions involving NMDA receptor activation, including the AIDS dementia complex (HAD). " 03/05/1998 - "OBJECTIVE: Concentrations of quinolinic acid, an N-methyl-D-aspartate agonist, are often elevated for long periods of time in the cerebrospinal fluid (CSF) and brain tissue of patients with AIDS dementia complex (ADC). " 08/01/2008 - "Memantine, an uncompetitive NMDA receptor antagonist, which has been recently approved for the treatment of Alzheimer's disease, is being discussed as a potential adjunctive therapeutic substance for HIV dementia. " Order ALL the reference details at left...
8.	Didanosine (Videx)FDA LinkGeneric 11/24/1995 - "Whether this difference in CSF levels is the explanation for the presumed lower efficacy of didanosine in the prevention and treatment of AIDS dementia complex remains to be proven. " 01/01/1996 - "In a pilot open-labeled study 10 subjects with AIDS dementia complex (ADC) were treated with didanosine. " 01/01/1996 - "Pilot Study of Didanosine in Patients with HIV Dementia." 09/10/1994 - "AIDS dementia complex and didanosine." 07/01/1992 - "However, the effects of didanosine on clinical end-points (disease progression, survival, HIV encephalopathy) remain to be established. " Order ALL the reference details at left...
9.	CreatineIBA 05/01/1995 - "It is concluded that N-acetyl aspartate/creatine ratios are reduced in childhood AIDS encephalopathy and proton magnetic resonance spectroscopy may be helpful in defining brain human immunodeficiency virus-1 infection. " 01/01/1999 - "Significant (P < 0.05) reductions in the N-acetyl-L-aspartate (NAA)/total creatine (Cr), and NAA/total choline (Cho) ratios and significant increases in Cho/Cr occurred in patients with 1) AIDS-defining diagnoses; 2) <200 CD4 lymphocyte counts/microl; 3) neurological evidence for an AIDS dementia complex (ADC); 4) magnetic resonance imaging (MRI) signs of cerebral atrophy. " 06/01/2003 - "PURPOSE: To demonstrate the technical feasibility and reliability of a multi-center study characterizing regional levels of the brain metabolite ratios choline (Cho)/creatine (Cr) and myoinositol (MI)/Cr, markers of glial cell activity, and N-acetyl aspartate (NAA)/Cr, a marker of mature neurons, in subjects with AIDS dementia complex (ADC). " 08/01/1997 - "RESULTS: With the STEAM (TE, 20 mseconds) spectra, mean N-acetylaspartate (NAA)/choline (Cho) and NAA/creatine and phosphocreatine (Cr-PCr) ratios are reduced in acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) patients but not in neuroasymptomatics. " Order ALL the reference details at left...
10.	Methylphenidate (Ritalin)FDA LinkGeneric 05/01/1992 - "We performed a double-blind, placebo-controlled n-of-1 trial to learn whether methylphenidate was an effective treatment for depression in an outpatient with mild HIV dementia. " Order ALL the reference details at left...

Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART) 09/10/2009 - "The use of HAART was highly effective in reducing the incidence of HIV encephalopathy among perinatally infected children and adolescents. " 07/04/2003 - "Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy." 04/01/2002 - "Highly active antiretroviral therapy has not eliminated HIV dementia, but it has changed the problem from one that strikes with severity and quickly leads to death to a process of slow, chronic cognitive decline, according to new research. " 09/10/2009 - "This is the first large study to evaluate the impact of HAART and central nervous system (CNS)-penetrating antiretroviral regimens on the incidence of HIV encephalopathy and survival after diagnosis of HIV encephalopathy among perinatally infected children. " 09/15/2007 - "OBJECTIVE: The objective of this study was to compare the HIV Dementia Scale (HDS) with comprehensive neuropsychological procedures in detecting both minor cognitive and motor disorder (MCMD) and HIV-D in a population of patients with varying durations of HAART. " Order ALL the reference details at left...
2.	First Aid (Aids, First) 08/01/2007 - "Neurological complications developed as the first AIDS-defining disease for 8.3% of AIDS patients in 1999-2001 and for 5.4% in 2002-3. Prevalences of HIV encephalopathy and myelopathy decreased markedly over the study period, as reported in other developed nations. " 08/01/2003 - "HIV disease progression was evaluated with respect to three outcome measures: (1) number of years from baseline testing to the first AIDS defining illness (progression to AIDS), (2) years from baseline to HIV-dementia (progression to dementia), and (3) years from baseline to death (survival). " Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 09/01/1999 - "This common pathway is similar to that seen in acute neuronal injury and CNS degenerative diseases and may make HIV encephalopathy amenable to pharmacotherapy. " 04/01/1997 - "Pharmacotherapy of HIV dementia." 07/01/2003 - "Changes in the absolute or relative concentrations of these kynurenines have been implicated in a variety of central nervous system disorders such as the AIDS-dementia complex and Huntington's disease, raising the possibility that interference with their actions or synthesis could lead to new forms of pharmacotherapy for these conditions." Order ALL the reference details at left...
4.	Aftercare (After-Treatment) 04/01/2000 - "CONCLUSION: Although our patient population was small, the results suggest that disease regression in patients with AIDS dementia complex after treatment with highly active antiretroviral therapy can be characterized and monitored by MR imaging." 07/01/1997 - "Moreover, there is evidence indicating that HIV dementia is not a homogeneous entity and could partially reverse after treatment with zidovudine. " 02/01/1991 - "After treatment of AIDS dementia complex with zidovudine and treatment of the opportunistic infections with specific antimicrobial therapies, CSF levels of quinolinic acid decreased in parallel with clinical neurological improvement. " Order ALL the reference details at left...
5.	Nursing Care 12/01/1994 - "Using the stages of AIDS dementia complex, guidelines for nursing care are proposed. " 12/01/1994 - "As a basis for examining aspects of nursing care, the epidemiology, neuropathology, clinical presentation and diagnosis of AIDS dementia complex are reviewed and medical management considered. " 12/01/1994 - "To date, the nursing care of individual with AIDS dementia complex has not been explored to any extent. " 12/01/1994 - "AIDS dementia complex: guidelines for nursing care." 08/01/1989 - "Nursing care parameters are identified to facilitate mutual planning among persons with AIDS dementia complex, their significant others and nurses throughout disease progression. " Order ALL the reference details at left...