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Rett Syndrome (Rett's Disorder)

An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
Also Known As:
Rett's Disorder; Syndrome, Rett; Rett's Syndrome; Autism Dementia Ataxia Loss of Purposeful Hand Use Syndrome; Cerebroatrophic Hyperammonemia; Rett Disorder; Cerebroatrophic Hyperammonemias; Hyperammonemia, Cerebroatrophic; Hyperammonemias, Cerebroatrophic; Retts Syndrome; Syndrome, Rett's; Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome
Networked: 894 relevant articles (16 outcomes, 79 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Autistic Disorder (Autism)
2. Tuberous Sclerosis (Bourneville's Disease)
3. Down Syndrome (Down's Syndrome)
4. Pervasive Child Development Disorders
5. Prader-Willi Syndrome (Syndrome, Prader-Willi)

Experts

1. Zoghbi, Huda Y: 23 articles (11/2015 - 01/2002)
2. Hayek, Joussef: 20 articles (09/2015 - 08/2009)
3. Neul, Jeffrey L: 18 articles (11/2015 - 04/2004)
4. Signorini, Cinzia: 18 articles (01/2015 - 08/2009)
5. Leoncini, Silvia: 18 articles (01/2015 - 08/2009)
6. De Felice, Claudio: 18 articles (01/2015 - 08/2009)
7. Ciccoli, Lucia: 18 articles (01/2015 - 08/2009)
8. Valacchi, Giuseppe: 17 articles (08/2014 - 08/2009)
9. LaSalle, Janine M: 16 articles (07/2012 - 06/2002)
10. Bienvenu, Thierry: 15 articles (12/2015 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rett Syndrome:
1. beta-Endorphin (Endorphin, beta)IBA
2. Naltrexone (ReVia)FDA LinkGeneric
3. Brain-Derived Neurotrophic Factor (BDNF)IBA
4. Methyl-CpG-Binding Protein 2IBA
5. Biogenic Amines (Biogenic Amine)IBA
6. Folic Acid (Vitamin M)FDA LinkGeneric
7. Carnitine (L-Carnitine)FDA LinkGeneric
8. Buspirone (Buspar)FDA LinkGeneric
9. MicroRNAs (MicroRNA)IBA
10. Biotin (Vitamin H)FDA Link

Therapies and Procedures

1. Therapeutics
2. Splints
3. Self-Help Devices (Assistive Technology)
4. Dilatation and Curettage (D&C)
5. Cholecystectomy