Investigational Drugs

Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.

Also Known As:

Networked: 967 relevant articles (39 outcomes, 251 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stacpoole, Peter W: 13 articles (11/2020 - 07/2003)
2.	James, Margaret O: 9 articles (11/2020 - 03/2008)
3.	Davis, Robert E: 5 articles (02/2016 - 03/2014)
4.	Langaee, Taimour: 4 articles (01/2020 - 10/2008)
5.	Ivy, S Percy: 4 articles (09/2019 - 03/2010)
6.	Pusztai, Lajos: 4 articles (05/2018 - 07/2012)
7.	Vanover, Kimberly E: 4 articles (02/2016 - 03/2014)
8.	Wiederhold, Nathan P: 3 articles (08/2022 - 12/2015)
9.	Reaman, Gregory: 3 articles (01/2022 - 11/2020)
10.	Yonemori, Kan: 3 articles (01/2022 - 12/2016)

Related Diseases

1.	COVID-19 04/01/2023 - "Investigational New Drug studies to evaluate the safety, tolerability and preliminary efficacy of ISH0339 for both prophylactic and therapeutic purposes against SARS-CoV-2 infection have been filed." 12/01/2021 - "Efficacy of the current investigational drugs for the treatment of COVID-19: a scoping review." 01/01/2023 - "This study is an analysis of the changes to workload and operations of UNC Health's investigational drug service (IDS) brought about by the coronavirus disease 2019 (COVID-19) pandemic. " 03/16/2021 - "Studies posted with the shortest response time were Academic-sponsored trials and included smaller sized investigations of repurposed approved or investigational drugs for the treatment of COVID-19 symptoms. " 01/01/2021 - "Since developing a new drug is time consuming, many approved or investigational drugs have been repurposed for COVID-19 treatment in clinical trials. "
2.	Epilepsy (Aura) 01/01/1992 - "The remaining patients are often considered for trial of an investigational drug although prospects for important improvement are very small even with use of agents shown to be effective and introduced for treatment of epilepsy. " 12/01/1990 - "Referral of affected patients to a comprehensive epilepsy center for possible surgical treatment and investigational drug studies should be considered. " 01/01/2020 - "Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. " 03/01/1998 - "Since long-term treatment with a placebo alone is ethically unacceptable in epilepsy, the classical monotherapy assessment of antiepileptic drugs involves randomization of newly diagnosed patients to treatment with the investigational drug or an established active control, followed by long-term monitoring to determine seizure remission rates and potential adverse effects. " 09/01/2016 - "We have searched the investigational drugs using the key words 'antiepileptic drugs,' 'epilepsy,' 'Phase I,' 'Phase II' and 'Phase III' in American clinical trial registers (clinicaltrials.gov), the relevant published articles using National Library of Medicine's PubMed database, company websites and supplemented results with a manual search of cross-references and conference abstracts. "
3.	Pain (Aches) 01/01/2015 - "In addition, publications representing Phase I-III trials of investigational drugs (2009-2013) did not indicate great enthusiasm on the part of the pharmaceutical industry regarding drugs specifically designed for treatment of pain. " 01/01/2015 - "The following scientometric indices were used: the popularity index, representing the share of articles (or patents) on a specific topic among all articles (or patents) on pain over the same 5-year period; the index of change, representing the change in the number of articles (or patents) on a topic from one 5-year period to the next; the index of expectations, representing the ratio of the number of all types of articles on a topic in the top 20 journals relative to the number of articles in all (>5,000) biomedical journals covered by PubMed over a 5-year period; the total number of articles representing Phase I-III trials of investigational drugs over a 5-year period; and the trial balance index, a ratio of Phase I-II publications to Phase III publications. " 04/01/2016 - "None of the currently available drugs are fully effective against the whole spectrum of symptoms of pain, fatigue, sleep disturbances and depression, but increasing efforts by the pharmaceutical industry have led to the introduction of new investigational drugs and new formulations of older drugs, as well as studies of the possibility of applying drugs currently used for other diseases. " 01/01/2017 - "Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain." 04/30/2019 - "This is an institutional review board- and investigational new drug-approved, prospective phase I/II trial to investigate the safety and use of intranasal ketamine in patients with uncontrolled pain related to cancer or cancer treatment. "
4.	Inflammation (Inflammations) 12/01/2007 - "A new, easy-to-use and robust activity index predicting mucosal inflammation is highly needed to assess the response to investigational drugs in trials and the effect of therapeutical interventions in clinical practice." 07/01/2019 - "The establishment of in vitro UC model using human colonic organoid could reveal the effects and targets of investigational drugs in intestinal epithelial cells under inflammation conditions. " 01/01/2012 - "This paper reviews current and investigational drug delivery systems for treating vitreous inflammation as well as other pathologic conditions that induce visual loss. " 11/15/2011 - "The cardiovascular profile of other biologic therapies for the treatment of RA has not been adequately studied, including of investigational drugs that improve systemic inflammation but alter traditional cardiovascular risk factors. " 12/01/2015 - "Segmental endotoxin challenge with lipopolysaccharide (LPS) can be used as a pharmacodynamic model to safely induce a transient airway inflammation in the peripheral lung of healthy subjects and to test the anti-inflammatory efficacy of investigational new drugs. "
5.	Mucormycosis 12/01/2015 - "We studied the efficacy of the investigational drug VT-1161 against mucormycosis. " 01/01/2014 - "We studied the in vitro and in vivo efficacies of the investigational drug isavuconazole against mucormycosis due to Rhizopus delemar. " 01/01/2017 - "We compared prophylactic or continuous therapy with the investigational drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. "

Related Drugs and Biologics

1.	VT-1161
2.	Interleukin-2 (IL2)
3.	Vaccines
4.	Phosphotransferases (Kinase)
5.	Oxygen (Dioxygen)
6.	lumateperone
7.	DNA (Deoxyribonucleic Acid)
8.	flavone acetic acid
9.	Protein Kinases (Protein Kinase)
10.	posaconazole

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Female Contraceptive Devices (Vaginal Ring)
4.	Slit Lamp
5.	Drug Therapy (Chemotherapy)