Acute Eosinophilic Leukemia

A rare acute myeloid leukemia characterized by abnormal EOSINOPHILS in the bone marrow.

Also Known As:

Leukemia, Eosinophilic, Acute; Acute Eosinophilic Leukemias; Eosinophilic Leukemias, Acute; Leukemia, Acute Eosinophilic; Leukemias, Acute Eosinophilic; Eosinophilic Leukemia, Acute

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Leukemia: 58722
    - Myeloid Leukemia: 4026
      - Acute Myeloid Leukemia: 26405
        Acute Eosinophilic Leukemia: 6
Hemic and Lymphatic Diseases: 6
- Hematologic Diseases: 3366
  - Leukemia: 58722
    - Myeloid Leukemia: 4026
      - Acute Myeloid Leukemia: 26405
        Acute Eosinophilic Leukemia: 6

Related Diseases

1.	Leukemia
2.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
3.	Acute Basophilic Leukemia
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
5.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)

Experts

1.	Bandobashi, Kentaro: 1 article (09/2007)
2.	Ikezoe, Takayuki: 1 article (09/2007)
3.	Koeffler, H Phillip: 1 article (09/2007)
4.	Komatsu, Naoki: 1 article (09/2007)
5.	Kuwayama, Yoshio: 1 article (09/2007)
6.	Nishioka, Chie: 1 article (09/2007)
7.	Taguchi, Hirokuni: 1 article (09/2007)
8.	Taniguchi, Ayuko: 1 article (09/2007)
9.	Tasaka, Taizo: 1 article (09/2007)
10.	Togitani, Kazuto: 1 article (09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Eosinophilic Leukemia:

1.	ThymidineIBA 09/15/2007 - "AZD1152 inhibited the proliferation of AML lines (HL-60, NB4, MOLM13), ALL line (PALL-2), biphenotypic leukemia (MV4-11), acute eosinophilic leukemia (EOL-1), and the blast crisis of chronic myeloid leukemia K562 cells with an IC50 ranging from 3 nM to 40 nM, as measured by thymidine uptake on day 2 of culture. "
2.	Ligases (Synthetase)IBA 11/01/1999 - "We identified a novel human long fatty acyl CoA synthetase 2 gene, ACS2, as a new ETV6 fusion partner gene in a recurrent t(5;12)(q31;p13) translocation in a patient with refractory anemia with excess blasts (RAEB) with basophilia, a patient with acute myelogenous leukemia (AML) with eosinophilia, and a patient with acute eosinophilic leukemia (AEL). "
3.	Indicators and Reagents (Reagents)IBA 02/04/1985 - "In such a situation, in vitro colony formation closely resembling that of acute myoblastic leukemia together with the clinical, morphological, cytochemical, and cytogenetic characteristics reported might serve as an indicator that these patients run an acute course justifying a diagnosis of acute eosinophilic leukemia and immediate institution of aggressive chemotherapy. "
4.	AntigensIBA 05/13/1988 - "Acute T-lymphocytic leukemia diagnosed in a 14-year old boy on the basis of typical cell morphology, as well as by membrane antigen analysis with monoclonal antibodies, shifted to the phenotype of an acute eosinophilic leukemia 5 months after the initiation of chemotherapy. "
5.	Monoclonal AntibodiesIBA 05/13/1988 - "Acute T-lymphocytic leukemia diagnosed in a 14-year old boy on the basis of typical cell morphology, as well as by membrane antigen analysis with monoclonal antibodies, shifted to the phenotype of an acute eosinophilic leukemia 5 months after the initiation of chemotherapy. "
6.	Acyl Coenzyme A (Acyl CoA)IBA 11/01/1999 - "We identified a novel human long fatty acyl CoA synthetase 2 gene, ACS2, as a new ETV6 fusion partner gene in a recurrent t(5;12)(q31;p13) translocation in a patient with refractory anemia with excess blasts (RAEB) with basophilia, a patient with acute myelogenous leukemia (AML) with eosinophilia, and a patient with acute eosinophilic leukemia (AEL). "
7.	2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphateIBA 09/15/2007 - "AZD1152 inhibited the proliferation of AML lines (HL-60, NB4, MOLM13), ALL line (PALL-2), biphenotypic leukemia (MV4-11), acute eosinophilic leukemia (EOL-1), and the blast crisis of chronic myeloid leukemia K562 cells with an IC50 ranging from 3 nM to 40 nM, as measured by thymidine uptake on day 2 of culture. "
8.	antineoplaston A10 (A 10)IBA 06/01/1988 - "Acute eosinophilic leukemia with a (10;11) chromosomal translocation."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/04/1985 - "In such a situation, in vitro colony formation closely resembling that of acute myoblastic leukemia together with the clinical, morphological, cytochemical, and cytogenetic characteristics reported might serve as an indicator that these patients run an acute course justifying a diagnosis of acute eosinophilic leukemia and immediate institution of aggressive chemotherapy. " 05/13/1988 - "Acute T-lymphocytic leukemia diagnosed in a 14-year old boy on the basis of typical cell morphology, as well as by membrane antigen analysis with monoclonal antibodies, shifted to the phenotype of an acute eosinophilic leukemia 5 months after the initiation of chemotherapy. "
2.	Therapeutics 08/01/1993 - "Acute basophilic leukemia and acute eosinophilic leukemia after therapy for non-Hodgkin's lymphoma."