Chronic Neutrophilic Leukemia

A rare myeloproliferative disorder that is characterized by a sustained, mature neutrophilic leukocytosis. No monocytosis, EOSINOPHILIA, or basophilia is present, nor is there a PHILADELPHIA CHROMOSOME or bcr-abl fusion gene (GENES, ABL).
Also Known As:
Leukemia, Neutrophilic, Chronic; Chronic Neutrophilic Leukemias; Leukemia, Chronic Neutrophilic; Leukemias, Chronic Neutrophilic; Neutrophilic Leukemias, Chronic; Neutrophilic Leukemia, Chronic
Networked: 47 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Primary Myelofibrosis (Myelosclerosis)
2. Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
3. Philadelphia Chromosome
4. Paraproteinemias (Monoclonal Gammopathy)
5. Leukocytosis (Pleocytosis)


1. Tefferi, Ayalew: 4 articles (07/2015 - 08/2005)
2. Elliott, Michelle A: 3 articles (07/2015 - 05/2004)
3. Tyner, Jeffrey W: 3 articles (02/2014 - 09/2013)
4. Maxson, Julia E: 3 articles (02/2014 - 09/2013)
5. Pardanani, Animesh: 2 articles (07/2015 - 04/2006)
6. Lasho, Terra L: 2 articles (07/2015 - 08/2005)
7. Pardanani, A: 2 articles (06/2014 - 09/2013)
8. Tefferi, A: 2 articles (06/2014 - 09/2013)
9. Lasho, T L: 2 articles (06/2014 - 09/2013)
10. Druker, Brian J: 2 articles (02/2014 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Neutrophilic Leukemia:
1. Hydroxyurea (Hydrea)FDA LinkGeneric
2. imatinib (Gleevec)FDA Link
3. Granulocyte Colony-Stimulating Factor (G-CSF)IBA
4. INCB018424IBA
5. Alkaline PhosphataseIBA
09/01/1992 - "A high neutrophil alkaline phosphatase score and a normal bone marrow cell karyotype suggested that the patient had chronic neutrophilic leukemia rather than chronic myeloid leukemia. "
01/01/2013 - "Chronic neutrophilic leukemia (CNL) is a rare type of leukemia characterized by a proliferation mainly of mature neutrophils, elevated neutrophil-alkaline phosphatase activity, and no presence of the Philadelphia chromosome. "
02/01/1987 - "Chronic neutrophilic leukemia, which may be regarded a variant of myeloproliferative disease, is associated with mature peripheral neutrophilia, hepatosplenomegaly, tissue infiltration by mature and immature granulocytes, an elevated leucocyte alkaline phosphatase score, absence of the Ph1 chromosome and elevated vitamin B12. "
12/01/2004 - "Chronic Neutrophilic Leukemia (CNL) is a rare myeloproliferative disorder characterized by a persistent increase of mature peripheral neutrophils, myeloid hyperplasia in bone marrow, hepatosplenomegaly, elevated neutrophil alkaline phosphatase (NAP) and absence of Philadelphia chromosome, with no evidence of infection or malignancy sufficient to mimic a leukemoid reaction. "
02/01/2009 - "We diagnosed an 86-year-old woman with chronic neutrophilic leukemia (CNL) because she showed sustained leukocytosis dominated by mature neutrophils, hepatosplenomegaly, high neutrophilic alkaline phosphatase score, absence of the Ph chromosome, low serum level of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), and no evidence of leukemoid reaction. "
6. Colony-Stimulating Factors (Colony Stimulating Factor)IBA
7. Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
8. Immunoglobulin G (IgG)IBA
9. Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA
10. Protein-Tyrosine Kinases (Tyrosine Kinase)IBA

Therapies and Procedures

1. Bone Marrow Transplantation (Transplantation, Bone Marrow)
2. Stem Cell Transplantation
3. Activities of Daily Living (ADL)