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BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)

Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Also Known As:
Chronic Myelogenous Leukemia; Chronic Myeloid Leukemia; Leukemia, Myeloid, Philadelphia Positive; Chronic Granulocytic Leukemia; Leukemia, Chronic Myelogenous; Leukemia, Chronic Myeloid; Myeloid Leukemia, Chronic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelogenous, Ph1 Positive; Leukemia, Myelogenous, Ph1-Positive; Leukemia, Myeloid, Ph1 Positive; Leukemia, Myeloid, Ph1-Positive; Leukemia, Myeloid, Philadelphia-Positive; Myelogenous Leukemia, Ph1-Positive; Myeloid Leukemia, Ph1-Positive; Myeloid Leukemia, Philadelphia-Positive; Chronic Granulocytic Leukemias; Chronic Myelocytic Leukemia; Chronic Myelocytic Leukemias; Chronic Myelogenous Leukemias; Chronic Myeloid Leukemias; Granulocytic Leukemias, Chronic; Leukemia, Chronic Granulocytic; Leukemia, Chronic Myelocytic; Leukemia, Ph1-Positive Myelogenous; Leukemia, Ph1-Positive Myeloid; Leukemia, Philadelphia-Positive Myeloid; Leukemias, Chronic Granulocytic; Leukemias, Chronic Myelocytic; Leukemias, Chronic Myelogenous; Leukemias, Chronic Myeloid; Leukemias, Ph1-Positive Myelogenous; Leukemias, Ph1-Positive Myeloid; Leukemias, Philadelphia-Positive Myeloid; Myelocytic Leukemias, Chronic; Myelogenous Leukemia, Ph1 Positive; Myelogenous Leukemias, Chronic; Myelogenous Leukemias, Ph1-Positive; Myeloid Leukemia, Ph1 Positive; Myeloid Leukemia, Philadelphia Positive; Myeloid Leukemias, Chronic; Myeloid Leukemias, Ph1-Positive; Myeloid Leukemias, Philadelphia-Positive; Ph1-Positive Myelogenous Leukemia; Ph1-Positive Myelogenous Leukemias; Ph1-Positive Myeloid Leukemia; Ph1-Positive Myeloid Leukemias; Philadelphia-Positive Myeloid Leukemia; Philadelphia-Positive Myeloid Leukemias; Granulocytic Leukemia, Chronic; Leukemia, Granulocytic, Chronic; Leukemia, Myelocytic, Chronic; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid, Chronic; Myelocytic Leukemia, Chronic; Myelogenous Leukemia, Chronic
Networked: 9684 relevant articles (879 outcomes, 955 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Leukemia
2. Philadelphia Chromosome
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
5. Blast Crisis (Blast Phase)

Experts

1. Cortes, Jorge: 219 articles (12/2015 - 03/2002)
2. Kantarjian, Hagop: 177 articles (12/2015 - 02/2002)
3. Hochhaus, Andreas: 115 articles (05/2015 - 01/2002)
4. O'Brien, Susan: 111 articles (11/2015 - 04/2002)
5. Kantarjian, Hagop M: 101 articles (10/2015 - 03/2002)
6. Baccarani, Michele: 96 articles (09/2015 - 02/2002)
7. Saglio, Giuseppe: 87 articles (10/2015 - 02/2002)
8. Druker, Brian J: 83 articles (01/2015 - 01/2002)
9. Jabbour, Elias: 79 articles (12/2015 - 01/2006)
10. Breccia, Massimo: 78 articles (10/2015 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to BCR-ABL Positive Chronic Myelogenous Leukemia:
1. imatinib (Gleevec)FDA Link
2. Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
3. Interferon-alpha (Interferon Alfa)FDA Link
4. dasatinib (BMS 354825)FDA Link
5. InterferonsIBA
6. 4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib)FDA Link
7. Bcr-Abl tyrosine kinaseIBA
8. Phosphotransferases (Kinase)IBA
9. Busulfan (Busulfex)FDA Link
10. Cytarabine (Cytosar-U)FDA LinkGeneric

Therapies and Procedures

1. Bone Marrow Transplantation (Transplantation, Bone Marrow)
2. Transplants (Transplant)
3. Stem Cell Transplantation
4. Transplantation (Transplant Recipients)
5. Drug Therapy (Chemotherapy)