Adult T-Cell Leukemia-Lymphoma (T-ALL)

2012  relevant articles (88 outcomes, 155 trials/studies) found for this Disease

T-ALL; Leukemia Lymphoma, T Cell, Acute, HTLV I Associated; ATLL; Leukemia, Adult T Cell; Leukemia-Lymphoma, Adult T-Cell; HTLV I Associated T Cell Leukemia Lymphoma; HTLV-Associated Leukemia-Lymphoma; HTLV-I-Associated T-Cell Leukemia-Lymphoma; Human T Lymphotropic Virus Associated Leukemia Lymphoma; Human T Lymphotropic Virus-Associated Leukemia-Lymphoma; Human T-Cell Leukemia-Lymphoma; Leukemia Lymphoma, Adult T Cell; Leukemia, Adult T-Cell; Leukemia, Lymphoblastic, Acute, T Cell; Leukemia, Lymphocytic, Acute T Cell; Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated; Lymphoblastic Leukemia, Acute, T Cell; Lymphocytic Leukemia, T Cell, Acute; T Cell Leukemia Lymphoma, HTLV I Associated; T Cell Leukemia, Adult; T-Cell Leukemia, Adult; T-Cell Leukemia-Lymphoma, Adult; T-Cell Leukemia-Lymphoma, HTLV-I-Associated; Acute T-Cell Leukemia; Acute T-Cell Leukemias; Acute T-Lymphocytic Leukemia; Acute T-Lymphocytic Leukemias; Adult T-Cell Leukemia; Adult T-Cell Leukemia-Lymphomas; Adult T-Cell Leukemias; HTLV Associated Leukemia Lymphoma; HTLV-Associated Leukemia-Lymphomas; HTLV-I-Associated T-Cell Leukemia-Lymphomas; Human T Cell Leukemia Lymphoma; Human T-Cell Leukemia-Lymphomas; Leukemia, Acute T-Cell; Leukemia, Acute T-Lymphocytic; Leukemia-Lymphoma, HTLV-Associated; Leukemia-Lymphoma, HTLV-I-Associated T-Cell; Leukemia-Lymphoma, Human T-Cell; Leukemia-Lymphomas, Adult T-Cell; Leukemia-Lymphomas, HTLV-Associated; Leukemia-Lymphomas, HTLV-I-Associated T-Cell; Leukemia-Lymphomas, Human T-Cell; Leukemias, Acute T-Cell; Leukemias, Acute T-Lymphocytic; Leukemias, Adult T-Cell; T Cell Leukemia Lymphoma, Adult; T Cell Leukemia, Acute; T Lymphocytic Leukemia, Acute; T-Cell Leukemia-Lymphoma, Human; T-Cell Leukemia-Lymphomas, Adult; T-Cell Leukemia-Lymphomas, HTLV-I-Associated; T-Cell Leukemia-Lymphomas, Human; T-Cell Leukemias, Acute; T-Cell Leukemias, Adult; T-Lymphocytic Leukemias, Acute; Leukemia, Lymphoblastic, Acute, T-Cell; Leukemia, Lymphocytic, Acute, T-Cell; Leukemia, T-Cell, Acute; Lymphoblastic Leukemia, Acute, T-Cell; Lymphocytic Leukemia, T-Cell, Acute; T-Cell Leukemia, Acute; T-Lymphocytic Leukemia, Acute

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Adult T-Cell Leukemia-Lymphoma (T-ALL)
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
3.	Lymphoma (Lymphomas)
4.	Leukemia
5.	T-Cell Leukemia (Leukemia, T Cell)

Experts

1.	Tomonaga, Masao: 16 articles (06/2008 - 01/2002)
2.	Utsunomiya, Atae: 15 articles (06/2008 - 02/2002)
3.	Yamada, Yasuaki: 15 articles (12/2007 - 01/2002)
4.	Tomonaga, M: 11 articles (06/2007 - 04/2000)
5.	Mori, Naoki: 11 articles (03/2006 - 02/2002)
6.	Masuda, Masato: 9 articles (06/2008 - 06/2003)
7.	Waldmann, Thomas A: 9 articles (05/2008 - 02/2002)
8.	Yamamoto, Naoki: 9 articles (05/2008 - 02/2002)
9.	Tsukasaki, Kunihiro: 8 articles (12/2007 - 09/2002)
10.	Kamihira, Shimeru: 8 articles (12/2007 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adult T-Cell Leukemia-Lymphoma:

1.	sobuzoxaneIBA 04/01/1993 - "MST-16 was shown to be effective in ATLL, which has no standard therapy" 01/01/1992 - "Effective treatment of adult T cell leukemia/lymphoma with a novel oral antitumor agent, MST-16." 04/01/1993 - "Treatment of adult T-cell leukemia/lymphoma with MST-16, a new oral antitumor drug and a derivative of bis(2,6-dioxopiperazine)" 01/01/1992 - "Orally administered MST-16 is a promising agent for the treatment of ATLL." 01/01/1992 - "Six patients with ATLL were treated with a new antitumor agent, MST-16, which is a derivative of bis(2,6-dioxopiperazine)" Order ALL the reference details at left...
2.	Cyclophosphamide (Cytoxan)FDA Link 01/01/2006 - "Eight ATLL patients underwent unrelated BMT; five received the conventional conditioning regimen consisting of cyclophosphamide and total body irradiation, while three received a reduced-intensity preparative regimen" 01/01/2002 - "A 47-year-old woman with adult T-cell leukemia in remission was treated with high-dose cyclophosphamide as a preparative regimen for allogeneic bone marrow transplantation" 12/01/1987 - "A 43-year-old patient with adult T cell leukemia (ATL) was treated with mega-dose cyclophosphamide and total body irradiation (TBI) followed by bone marrow transplantation (BMT) from his HLA-identical sibling who was not a carrier of ATL virus" 12/01/1987 - "Treatment of adult T cell leukemia with mega-dose cyclophosphamide and total body irradiation followed by allogeneic bone marrow transplantation." 07/01/1995 - "Two patients developed acute leukemia; however, one had adult T-cell leukemia associated with human T-lymphotrophic virus type 1 (HTLV-1) and a second patient developed AML after receiving additional cyclophosphamide for metastatic breast cancer" Order ALL the reference details at left...
3.	InterferonsIBA 12/28/2007 - "On the other hand, treatment with interferon (IFN)-alpha is sometimes effective in ATLL, particularly combined with other drugs" 12/01/2001 - "Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia." 08/01/1986 - "However, leukemic blasts from four T-ALL patients were 1G2+ and/or Leu 7+. Blasts from two of these had spontaneous lytic activity against standard NK target cell line K562; blasts from one killed K562 only when incubated with interferon; blasts from the other had no lytic activity against K562 but did manifest antibody-dependent cell-mediated cytotoxicity against antibody-coated cells from NK-resistant cell line SB" 03/01/1985 - "Among virus-associated cell lines, only Epstein-Barr virus-associated B-cell lines were sensitive to the interferon; adult T-cell leukemia virus-associated T-cell lines were not sensitive" 06/01/2004 - "Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T-cell leukemia/lymphoma: efficacy of anti-retroviral and interferon therapy." Order ALL the reference details at left...
4.	Vincristine (Oncovin)FDA LinkGeneric 05/01/1992 - "To study the selectivity of this action, the effect of addition of verapamil on the cytotoxicity of vincristine was studied using lymphocytes from eight patients with chronic lymphocytic leukemia (CLL), lymphoblasts from a T-acute lymphoblastic leukemia (T-ALL) cell line (GM 3639), and peripheral blood lymphocytes (PBL) from eight normal healthy volunteers" 09/01/1987 - "A case of adult T-cell leukemia achieving complete remission with epirubicin, vincristine and prednisolone chemotherapy]" 03/01/2008 - "The authors previously developed a T-lineage acute lymphoblastic leukemia (T-ALL) cell line that overexpresses ABCB1 and exhibits MDR to daunorubicin (DNR), prednisolone, and vincristine" 12/01/2003 - "We report a case of human T-cell lymphotropic virus 1 (HTLV-1)-associated adult T cell leukemia/lymphoma (ATL) in clinical remission > 1 year after therapy with denileukin diftitox and hyper-CVAD (hyperfractionated cyclophosphamide/doxorubicin/vincristine/decadron)" 07/01/2002 - "Ten T-cell acute lymphoblastic (T-ALL) CEM cell lines selected for resistance toward methotrexate (CEM/MTX60PGA, CEM/MTX140LV, CEM/MTX1500LV, CEM/MTX5000PGA, CEM/MTXR1, CEM/MTXR2, and CEM/MTXR3), doxorubicin (CEM/ADR5000), vincristine (CEM/VCR1000), or hydroxyurea (CEM/HUR90), respectively, and parental drug-sensitive CCRF-CEM cells were analyzed using comparative genomic hybridization" Order ALL the reference details at left...
5.	Immunotoxins (Immunotoxin)IBA 08/01/1994 - "A SCID mouse model of human T-ALL has been used to determine the in vivo therapeutic efficacy of two anti-CD7-saporin immunotoxins constructed with either a hindered (HB2-SMPT-Sap) or non-hindered (HB2-SPDP-Sap) disulphide bond between antibody and saporin" 01/01/1997 - "In vitro, the 2-mer immunotoxin was 5.6 times more effective than the 1-mer immunotoxin at inhibiting protein synthesis in the CD7+ human T-cell acute lymphoblastic leukaemia (T-ALL) cell line HSB-2 and was also more effective at inhibiting HSB-2 cell proliferation" 06/15/1994 - "The double-chain immunotoxin was very cytotoxic toward IL2R-bearing cell lines, human activated T cells and fresh adult-T-cell-leukemia cells" 01/01/1987 - "Also PE-immunotoxins are currently being evaluated in Phase 1 clinical trials for the treatment of adult T-cell leukemia." 02/01/1994 - "These results demonstrate the useful application of human leukaemia xenografts in SCID mice and the potential therapeutic effect of an anti-CD7 immunotoxin in human T-ALL." Order ALL the reference details at left...
6.	AntigensIBA 06/01/1987 - "A study of the incidence of ATL (adult T-cell leukemia) and anti-ATLA (antibody to the ATL-associated antigen) in an ATL-non-endemic area]" 11/01/1984 - "Ultrastructural study of type C virus particles in phytohemagglutinin-stimulated lymphocytes from healthy adults seropositive to adult T-cell leukemia-associated antigens." 01/01/1983 - "Absorption studies revealed that in one patient only the autologous reactivity was directed against a restricted antigen, which could be detected only on the individual T-ALL blast cells" 08/01/2007 - "The positive rate of myeloid antigen expression in CD34(+) T-ALL (36.58%) was significantly higher than that in CD34(-) T-ALL (15.38%) (p < 0.01)" 08/01/2007 - "Among 140 cases of T-ALL, 12 (8.57%) was accompanied by B-lineage associated antigen expression" Order ALL the reference details at left...
7.	DNA (Deoxyribonucleic Acid)IBA 07/01/2001 - "Immunogenicity and protective efficacy of recombinant human T-cell leukemia/lymphoma virus type 1 NYVAC and naked DNA vaccine candidates in squirrel monkeys (Saimiri sciureus)." 04/01/2004 - "This study was designed to determine whether DNA hypomethylation-associated aberrant gene expression is involved in adult T-cell leukemia (ATL) leukemogenesis" 03/01/1998 - "Studies also revealed the existence of HTLV-1 provirus DNA in nuclei of sweat gland epithelial cells and vascular endothelial cells as well as lymphoid cells in ATLL patients" 01/01/1987 - "Later studies showed that 1) the geographical distribution of HAM follows that of adult T-cell leukemia (ATL) and 2) viruses detected in both disorders were identical by DNA blotting assay, but HAM and ATL are definitely expressed clinically as distinct from the other" 05/01/2008 - "HTLV-1 proviral DNA loads in smoldering ATLL group are significantly higher than those in asymptomatic carrier and cutaneous ATLL group" Order ALL the reference details at left...
8.	Monoclonal AntibodiesIBA 08/15/2004 - "We previously showed therapeutic efficacy of humanized anti-Tac (HAT), murine anti-Tac (MAT), and 7G7/B6 monoclonal antibodies, which recognize CD25, for human adult T-cell leukemia (ATL) in a murine model" 06/01/1988 - "Immunohistologic studies using monoclonal antibodies showed that most non-T-ALL cases were positive for CALLA and B4, whereas about 50% of them were positive for B1" 01/01/2008 - "Monoclonal antibodies to target cell differentiation markers on ATLL cells have already been proposed as therapeutic agents" 08/01/2007 - "Immunophenotyping was performed in 140 T-ALL patients by flow cytometry using a panel of monoclonal antibodies and CD45/SSC gating" 03/01/1993 - "Ganglioside expression on adult T-cell leukemia (ATL) and human T-cell lymphotropic virus type I (HTLV-I)-infected cells was determined by using a panel of monoclonal antibodies" Order ALL the reference details at left...
9.	Zidovudine (Retrovir)FDA LinkGeneric 01/01/1990 - "The antiviral effect of zidovudine was examined in an experimental model of adult T cell leukemia in rabbits" 01/01/1990 - "Antiviral effect of zidovudine in the experimental model of adult T cell leukemia in rabbits." 03/01/2005 - "Recently, antiretroviral therapy using the combination of zidovudine (AZT) and interferon alpha (IFN-alpha) has been shown to induce a high complete remission rate and to prolong the survival of ATLL patients" 02/01/2007 - "Important advances in the treatment of ATLL were reported with the combination of zidovudine (AZT) and interferon-alpha" 11/15/2005 - "Durable hematologic complete response and suppression of HTLV-1 viral load following alemtuzumab in zidovudine/IFN-{alpha}-refractory adult T-cell leukemia." Order ALL the reference details at left...
10.	Etoposide (VP 16)FDA LinkGeneric 09/01/1993 - "Adult T cell leukemia/lymphoma effectively treated with chronic oral etoposide]" 09/01/2001 - "Low-dose etoposide in a patient with adult T-cell leukemia/lymphoma who had severe complications]" 03/01/1995 - "We tried long-term oral administration of low-dose etoposide (LDE) for seven patients with adult T-cell leukemia " 12/15/1993 - "However, the effectiveness of low-dose etoposide as a treatment for adult T-cell leukemia (ATL) has not been established" 12/15/1993 - "Successful treatment of a patient with adult T-cell leukemia by daily oral administration of low-dose etoposide" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/1997 - "Chemotherapy for adult T-cell leukemia (ATL) has been reported to fail to induce complete remission because of drug resistance in most patients" 02/01/1996 - "The pathologic clone appeared after sequential chemotherapy treatment for AML-M5 when the patient was in complete remission before development of T-ALL" 10/26/1985 - "7 patients with immature T-ALL (median age 42 years, range 13-73) were treated with intensified chemotherapy regimens, and only one 47-year-old female entered a short-lived complete remission" 07/01/1984 - "Prognostically favorable factors for remission duration were response to chemotherapy within 4 weeks, age less than 35 years, a low initial leukocyte count, and the immunologic subtypes c-ALL with early response to therapy and T-ALL, where 61% and 58%, respectively, are still in complete remission at 3 years" 12/20/2006 - "CONCLUSION: SCT in CR1 is superior to treatment with chemotherapy alone for childhood HR-T-ALL." Order ALL the reference details at left...
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 03/06/1987 - "One patient with acute lymphocytic leukaemia (T-All) in second remission died of an extramedullary relapse 485 days after bone marrow transplantation" 01/01/2007 - "Although most ATLL patients lack a suitable HLA-matched related donor and require an HTLV-I-negative unrelated donor, little information is currently available regarding the outcome of unrelated bone marrow transplantation (UBMT) for ATLL" 01/01/2007 - "Allogeneic bone marrow transplantation from unrelated human T-cell leukemia virus-I-negative donors for adult T-cell leukemia/lymphoma: retrospective analysis of data from the Japan Marrow Donor Program." 08/01/2006 - "Successful treatment of HTLV-1-associated acute adult T-cell leukemia lymphoma by allogeneic bone marrow transplantation: a 12 year follow-up." 01/01/2006 - "More than 40 cases of ATLL treated by allogeneic bone marrow transplantation (BMT) from sibling donors have been reported, while there have been only a few cases of unrelated BMT for treatment of this disease" Order ALL the reference details at left...
3.	Hematopoietic Stem Cell Transplantation 06/01/2008 - "Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has proven effective in adult T-cell leukemia/lymphoma (ATL) patients" 06/01/2007 - "Small number of HTLV-1-positive cells frequently remains during complete remission after allogeneic hematopoietic stem cell transplantation that are heterogeneous in origin among cases with adult T-cell leukemia/lymphoma." 01/01/2001 - "Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation." 05/01/2005 - "Several groups, including ours, have reported encouraging results of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with ATLL" 05/01/2005 - "Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma." Order ALL the reference details at left...
4.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 07/01/1999 - "Molecular remission in adult T cell leukemia after autologous CD34+ peripheral blood stem cell transplantation." 05/01/2006 - "She suffered from adult T-cell leukemia and received peripheral blood stem cell transplantation (PBSCT)" 12/01/2005 - "Prolonged remission of adult T-cell leukemia/lymphoma treated with interferon-gamma following autologous peripheral blood stem cell transplantation." 07/01/2002 - "We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation" 07/01/2002 - "Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin." Order ALL the reference details at left...
5.	Combination Drug Therapy (Combination Chemotherapy) 04/01/1999 - "All 4 Ss-infected (Ss-positive) ATLL patients treated with combination chemotherapy achieved complete remission (CR) versus only 2 of 7 Ss-negative ATLL patients (p = .04)" 10/01/2003 - "Further analyses of gene expression signatures of T-ALL lymphoblasts are especially needed for patients treated on modern combination chemotherapy trials to clearly distinguish the 10% to 15% of patients who fail induction or relapse in the first year of treatment" 11/01/1999 - "He was diagnosed to have ATLL and, despite an initial response, became resistant to combination chemotherapy" 04/01/1999 - "By comparison with other ATLL patients studied for p53 expression, P53-positive ATLL were characterized by a lower response rate to combination chemotherapy (CR: 0 of 6 versus 4 of 6; p = .04) and a shorter survival (2 versus 9 months, p = .04)" 08/01/1994 - "A pilot study of alternate combination chemotherapy with rhG-CSF for adult T-cell leukemia/lymphoma]" Order ALL the reference details at left...