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Acute Biphenotypic Leukemia (Leukemia, Mixed Cell)

An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS.
Also Known As:
Leukemia, Mixed Cell; Leukemia, Biphenotypic, Acute; B and T Cell Acute Lymphoblastic Leukemia; B and T Cell Leukemia, Acute; Biphenotypic Acute Leukemia; Hybrid Acute Leukemias; Leukemia, Lymphocytic, Acute, Mixed Cell; Leukemia, Mixed, B and T Cell; Lymphocytic Leukemia, Acute, B and T Cell; Mixed-Lineage Acute Leukemias; Acute Biphenotypic Leukemias; Acute Leukemia, Biphenotypic; Acute Leukemia, Hybrid; Acute Leukemia, Mixed-Lineage; Acute Leukemias, Biphenotypic; Acute Leukemias, Hybrid; Acute Leukemias, Mixed-Lineage; Biphenotypic Acute Leukemias; Biphenotypic Leukemia, Acute; Biphenotypic Leukemias, Acute; Hybrid Acute Leukemia; Leukemia, Acute Biphenotypic; Leukemia, Biphenotypic Acute; Leukemia, Hybrid Acute; Leukemia, Mixed-Lineage Acute; Leukemias, Acute Biphenotypic; Leukemias, Biphenotypic Acute; Leukemias, Hybrid Acute; Leukemias, Mixed-Cell; Leukemias, Mixed-Lineage Acute; Mixed Lineage Acute Leukemias; Mixed-Cell Leukemia; Mixed-Cell Leukemias; Mixed-Lineage Acute Leukemia; B- and T-Cell Acute Lymphoblastic Leukemia; B- and T-Cell Leukemia, Acute; Leukemia, Lymphocytic, Acute, Mixed-Cell; Leukemia, Mixed, B- and T-Cell; Leukemia, Mixed-Cell; Lymphocytic Leukemia, Acute, B- and T-Cell
Networked: 74 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Leukemia
2. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Acute Monocytic Leukemia (Acute Monoblastic Leukemia)
5. Testicular Neoplasms (Testicular Cancer)

Experts

1. Karawajew, L: 2 articles (05/2013 - 02/2001)
2. Ratei, R: 2 articles (05/2013 - 02/2001)
3. Han, Yue: 2 articles (01/2011 - 09/2009)
4. Miao, Miao: 2 articles (01/2011 - 09/2009)
5. Marschalek, Rolf: 2 articles (09/2010 - 07/2009)
6. Meyer, Claus: 2 articles (09/2010 - 07/2009)
7. Qiu, Hui-Ying: 2 articles (09/2009 - 07/2009)
8. Labar, Boris: 2 articles (10/2008 - 10/2008)
9. Chen, Yan: 2 articles (06/2007 - 04/2007)
10. Li, Rui: 2 articles (06/2007 - 04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Biphenotypic Leukemia:
1. AntigensIBA
2. Cyclin A1IBA
3. Phosphotransferases (Kinase)IBA
4. Amino AcidsFDA Link
5. AZD 6244IBA
6. Peroxidase (Myeloperoxidase)IBA
7. Messenger RNA (mRNA)IBA
08/01/2006 - "[Biphenotypic Acute Leukemia with BCR-ABL mRNA Transcript b3a2 Type: A Case Report with Review of the Literature.]."
09/01/1993 - "We observed that expression of TdT mRNA and sterile transcription at both the Ig and TCR loci (transcription without gene rearrangement) was unexpectedly common in both acute biphenotypic leukemia and acute myelogenous leukemia (AML), and occurred in the absence of phenotypic lymphoid differentiation. "
05/01/1989 - "On analysis of molecular events associated with the Ph1 chromosome, the leukemic cells of a patient with CML in mixed crisis showed bcr rearrangement and an 8.5-kb bcr-abl chimeric mRNA, but those of a patient with Ph1-positive hybrid acute leukemia showed no 8.5-kb bcr-abl mRNA, as previously reported in a number of Ph1-positive acute lymphoblastic leukemia (ALL) cases. "
08/01/2003 - "Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia."
06/01/1998 - "Cyclin A1 mRNA was detectable in 11 of 11 patients with acute myeloid leukemia, three of three patients with acute biphenotypic leukemia, eight of eight patients with myelodysplastic syndrome, 59 of 69 patients with chronic myelogenous leukemia (CML) at diagnosis, 13 of 15 patients with CML in blastic transformation, 10 of 18 patients with chronic lymphocytic leukemia, two of nine patients with essential thrombocythemia, and only two of 10 patients with acute lymphoblastic leukemia (ALL) with both cyclin A1 RT-PCR positive ALL leukemias being undifferentiated relapses. "
8. Monoclonal AntibodiesIBA
9. DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
10. Imatinib Mesylate (Gleevec)FDA Link

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Hematopoietic Stem Cell Transplantation
3. Induction Chemotherapy
4. Therapeutics
5. Transplantation