B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)

3884  relevant articles (194 outcomes, 397 trials/studies) found for this Disease

Chronic Lymphocytic Leukemia; Lymphoma, Small Cell; Leukemia, B Cell, Chronic; Leukemia, Chronic Lymphoblastic; Leukemia, Chronic Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Diffuse Well-Differentiated Lymphocytic Lymphoma; Leukemia, Lymphoblastic, Chronic; Leukemia, Lymphocytic, Chronic, B Cell; Lymphoblastic Leukemia, Chronic; Lymphocytic Leukemia, Chronic; Lymphocytic Leukemia, Chronic, B Cell; Lymphocytic Lymphoma; Lymphocytic Lymphoma, Diffuse, Well Differentiated; Lymphocytic Lymphoma, Diffuse, Well-Differentiated; Lymphocytic Lymphoma, Well Differentiated; Lymphocytic Lymphoma, Well-Differentiated; Lymphoma, Lymphocytic; Lymphoma, Lymphocytic, Diffuse, Well Differentiated; Lymphoma, Lymphocytic, Diffuse, Well-Differentiated; Lymphoma, Lymphocytic, Well Differentiated; Lymphoma, Lymphocytic, Well-Differentiated; Lymphoma, Lymphoplasmacytoid, CLL; Lymphoma, Small Lymphocytic, Plasmacytoid; Lymphoma, Small-Cell; Lymphoplasmacytoid Lymphoma, CLL; Small-Cell Lymphoma; B Cell Chronic Lymphocytic Leukemia; B Cell Leukemia, Chronic; B Lymphocytic Leukemia, Chronic; B-Cell Leukemias, Chronic; B-Lymphocytic Leukemias, Chronic; CLL Lymphoplasmacytoid Lymphoma; CLL Lymphoplasmacytoid Lymphomas; Chronic B-Cell Leukemia; Chronic B-Cell Leukemias; Chronic B-Lymphocytic Leukemia; Chronic B-Lymphocytic Leukemias; Chronic Lymphoblastic Leukemia; Chronic Lymphoblastic Leukemias; Chronic Lymphocytic Leukemias; Diffuse Well Differentiated Lymphocytic Lymphoma; Leukemia, Chronic B-Cell; Leukemia, Chronic B-Lymphocytic; Leukemias, Chronic B-Cell; Leukemias, Chronic B-Lymphocytic; Leukemias, Chronic Lymphoblastic; Leukemias, Chronic Lymphocytic; Lymphoblastic Leukemias, Chronic; Lymphocytic Leukemias, Chronic; Lymphocytic Lymphoma, Small; Lymphocytic Lymphomas; Lymphocytic Lymphomas, Small; Lymphocytic Lymphomas, Well-Differentiated; Lymphoma, CLL Lymphoplasmacytoid; Lymphoma, Well-Differentiated Lymphocytic; Lymphomas, CLL Lymphoplasmacytoid; Lymphomas, Lymphocytic; Lymphomas, Small Lymphocytic; Lymphomas, Small-Cell; Lymphomas, Well-Differentiated Lymphocytic; Lymphoplasmacytoid Lymphomas, CLL; Small Cell Lymphoma; Small Lymphocytic Lymphoma; Small Lymphocytic Lymphomas; Small-Cell Lymphomas; Well-Differentiated Lymphocytic Lymphoma; Well-Differentiated Lymphocytic Lymphomas; B-Cell Leukemia, Chronic; B-Lymphocytic Leukemia, Chronic; Leukemia, B-Cell, Chronic; Leukemia, Lymphocytic, Chronic; Lymphocytic Leukemia, Chronic, B-Cell; Lymphoma, Small Lymphocytic

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Non-Hodgkin Lymphoma (Lymphosarcoma)
2.	Neoplasms (Cancer)
3.	Hairy Cell Leukemia
4.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)

Experts

1.	Byrd, John C: 39 articles (09/2008 - 02/2002)
2.	Keating, Michael J: 35 articles (09/2008 - 02/2002)
3.	Robak, Tadeusz: 24 articles (07/2008 - 01/2002)
4.	Kipps, Thomas J: 23 articles (09/2008 - 03/2002)
5.	O'Brien, Susan: 20 articles (08/2008 - 02/2002)
6.	Kay, Neil E: 18 articles (12/2008 - 10/2002)
7.	Grever, Michael R: 18 articles (09/2008 - 06/2003)
8.	Rai, Kanti R: 16 articles (09/2008 - 06/2002)
9.	Wierda, William G: 16 articles (09/2008 - 06/2003)
10.	Ferrajoli, Alessandra: 15 articles (07/2008 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to B-Cell Chronic Lymphocytic Leukemia:

1.	fludarabineIBA 01/01/2003 - "Fludarabine combined with cyclophosphamid is highly effective in the treatment of chronic lymphocytic leukemia." 07/01/1994 - "Fludarabine, a nucleoside analogue that may activate apoptosis, has emerged as the most effective agent for newly diagnosed as well as relapsed patients with chronic lymphocytic leukemia" 01/15/1993 - "Complete remission after fludarabine for chronic lymphocytic leukemia." 10/08/1992 - "Patients with untreated B-cell chronic lymphocytic leukemia have a high rate of complete remission when given the halogenated nucleoside analogue fludarabine" 07/01/2002 - "PURPOSE: Fludarabine is a renally excreted agent that is an effective treatment for chronic lymphocytic leukemia (CLL), a disease predominantly of the elderly" Order ALL the reference details at left...
2.	alemtuzumab (Campath)FDA Link 01/15/2005 - "The anti-CD52 antibody alemtuzumab is effective in the treatment of patients with chronic lymphocytic leukemia (CLL)" 03/15/2004 - "Alemtuzumab therapy is effective for some refractory chronic lymphocytic leukemia (CLL), but identifying responders requires at least 8 weeks of therapy" 02/01/2004 - "Campath-1H is known as an effective treatment of chronic lymphocytic leukemia (CLL)" 06/01/2004 - "Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission--experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)." 08/01/2002 - "Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)." Order ALL the reference details at left...
3.	CladribineFDA LinkGeneric 04/01/1993 - "High complete remission rate from 2-chloro-2'-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count." 11/15/2000 - "In this study it is shown, by means of several assays on whole cells and isolated mitochondria, that 2-chloro-2'-deoxyadenosine (2CdA) and 2-choloro-2'-ara-fluorodeoxyadenosine (CaFdA) disrupt the integrity of mitochondria from primary chronic lymphocytic leukemia (B-CLL) cells" 06/01/1999 - "The aim of our study was to determine the efficacy and toxicity of 2-chlorodeoxyadenosine (2-CdA) in 2-hour infusions in the treatment of elderly patients with B-cell chronic lymphocytic leukemia (B-CLL)" 04/01/1999 - "The aim of the study was to determine the effectiveness of 2-chlorodeoxyadenosine (2-CdA) administered in 2-h i.v. infusions in the treatment of B cell chronic lymphocytic leukemia (B-CLL) in patients 55 years old and younger" 01/01/1996 - "Current results and prospective trials of cladribine in chronic lymphocytic leukemia." Order ALL the reference details at left...
4.	rituximab (Mabthera)FDA Link 03/01/2004 - "Initiation of rituximab infusion in chronic lymphocytic leukemia patients leads to rapid clearance of CD20(+) cells" 06/01/2000 - "We report on two patients with chemoresistant B-cell chronic lymphocytic leukemia who were treated successfully with the monoclonal anti-CD 20 antibody rituximab" 11/15/2006 - "Treatment of chronic lymphocytic leukemia (CLL) patients with standard dose infusion of rituximab (RTX), 375 mg/m2, induces clearance of malignant cells from peripheral blood after infusion of 30 mg of RTX" 01/01/2002 - "Recently, several reports have been published claiming the efficacy of anti-CD20 monoclonal antibody (rituximab) in the treatment of B-cell chronic lymphocytic leukemia (B-CLL) and some related autoimmune complications" 01/01/2002 - "Efficacy of rituximab in the treatment of refractory chronic lymphocytic leukemia patient with bone marrow aplasia." Order ALL the reference details at left...
5.	Chlorambucil (Leukeran)FDA Link 01/01/1980 - "Forty patients with lymphocytic lymphoma were treated with escalating doses of chlorambucil biweekly starting at a dose of 0.4 mg/kg. Fifty percent of patients achieved a complete remission, usually after 6-12 months of therapy" 05/01/1956 - "Early experience with p-(N, N-di-2-chloroethyl)-aminophenylbutyric acid (CB 1348), a new chemotherapeutic agent effective in the treatment of chronic lymphocytic leukemia." 03/01/2003 - "Effect of chlorambucil on B-lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia--study of cellular ultrastructure]" 07/01/1999 - "The efficiency of Chlorambucil in the induction of apoptosis was investigated in the study, and measurable apoptosis parameters were compared to the other prognostic factors with the aim of possible prediction of clinical response to the therapy in the patients with CD5 + B-cell chronic lymphocytic leukemia (B-CLL)" 07/01/1999 - "In vivo study of spontaneous and therapy-induced apoptosis in patients with chronic lymphocytic leukemia treated with chlorambucil]" Order ALL the reference details at left...
6.	purineIBA 07/01/2003 - "OBJECTIVES: Therapeutic results in advanced chronic lymphocytic leukemia (CLL) are still unsatisfactory in terms of complete remission achievement and duration, in spite of the extensive use of purine analogs" 11/01/2004 - "The treatment of patients with chronic lymphocytic leukemia (CLL) who fail purine analogues is sub optimal" 05/01/2004 - "Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era." 09/01/2002 - "Resistance to purine analogs is emerging as a major problem in the management of patients with chronic lymphocytic leukemia (CLL)" 02/01/2002 - "Chronic lymphocytic leukemia is an incurable disease with few therapeutic options once patients fail purine analogue-based therapy" Order ALL the reference details at left...
7.	Cyclophosphamide (Cytoxan)FDA Link 02/01/1989 - "A 55-year-old male with chronic lymphocytic leukemia developed a skin eruption after receiving oral cyclophosphamide" 03/01/1970 - "Cyclophosphamide-induced changes in circulating lymphocyte kinetics in chronic lymphocytic leukemia." 01/01/2003 - "To determine its antitumor activity in combination with cyclophosphamide, we initiated a Phase II trial of the two agents in patients with advanced chronic lymphocytic leukemia (CLL) or prolymphocytic leukemia (PLL)" 02/01/1989 - "Cutaneous vasculitis due to cyclophosphamide therapy for chronic lymphocytic leukemia." 01/01/1983 - "We report a case of transitional cell carcinoma of the bladder after cyclophosphamide therapy for chronic lymphocytic leukemia" Order ALL the reference details at left...
8.	fludarabine monophosphate (Fludara)FDA LinkGeneric 04/01/2004 - "CONCLUSION: This study demonstrates that oral fludarabine phosphate is clinically effective and generally well tolerated by patients with previously untreated B-cell chronic lymphocytic leukemia" 12/01/1999 - "Phase II clinical study of SH L 573 (fludarabine phosphate) in patients with chronic lymphocytic leukemia]" 12/01/1997 - "In addition, fludarabine monophosphate (Fludara) was sufficiently active in advanced refractory patients that approval for this agent in chronic lymphocytic leukemia was granted by the Food and Drug Administration without comparative clinical trials" 12/01/1996 - "Fludara has been established as the most active single agent in chronic lymphocytic leukemia (CLL) in single arm and comparative clinical trials" 11/01/1995 - "AIMS: The study was carried out to investigate the efficacy and toxicity of fludarabine phosphate in the treatment of B-cell chronic lymphocytic leukemia (B-CLL) in previously treated patients" Order ALL the reference details at left...
9.	Alkylating AgentsIBA 09/01/2007 - "Front-line therapy for chronic lymphocytic leukemia (CLL) with alkylating agents is associated with low rates of complete remission and no improvement in overall survival" 08/01/2006 - "Traditionally, the goal of therapy in chronic lymphocytic leukemia (CLL) has been palliative, with first-line therapy using alkylating agents and/or involved field radiotherapy (depending on the stage of disease and sites of involvement) because of the older age of affected patients and the low rate of complete remissions (CRs) with no improvement in overall survival despite treatment" 11/01/2003 - "The best approach to elderly patients with relapsing chronic lymphocytic leukemia (CLL) or disease refractory to conventional therapy with alkylating agents has not yet been established" 06/01/2002 - "Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia." 11/01/1997 - "DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia." Order ALL the reference details at left...
10.	Immunoglobulins (Immunoglobulin)IBA 12/01/2004 - "Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemia (B-CLL) may yield insight into leukemogenesis and may help to refine prognostic categories" 01/01/2003 - "Recent studies have demonstrated that B-cell chronic lymphocytic leukemia (CLL) consists of two clinical entities with either somatically hypermutated (M-CLL) or unmutated (UM-CLL) immunoglobulin variable heavy-chain (VH) regions" 03/15/2002 - "Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes" 02/15/2000 - "In this study, we wished to determine whether familial chronic lymphocytic leukemia of B-cell phenotype (CLL) shares with sporadic B-CLL the same immunoglobulin (Ig) heavy chain variable region (VH) gene usage and occurrence of somatic mutation, to gain insight into the pathogenetic relatedness of these epidemiologically distinct forms of CLL" 04/01/1993 - "Studies of immunoglobulin surface expression in lymphocytes of peripheral blood, bone marrow and lymph nodes in patients with B-cell chronic lymphocytic leukemia]" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 08/01/2004 - "Novel therapeutic approaches with conventional chemotherapy and monoclonal antibody combinations have improved the complete remission rates in chronic lymphocytic leukemia" 08/08/2002 - "Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy." 06/01/1989 - "A case of prolymphocytic transformation of chronic lymphocytic leukemia (CLL) is presented in which complete peripheral morphometric remission and lengthy survival were observed after intensive chemotherapy" 05/15/1989 - "This study evaluates residual disease in 28 B-cell chronic lymphocytic leukemia (B-CLL) patients who obtained a clinicohematologic remission after intensive chemotherapy" 01/01/2000 - "B cell chronic lymphocytic leukemia (B-CLL) cannot be cured with conventional chemotherapy" Order ALL the reference details at left...
2.	Transplants (Transplant) 11/01/2005 - "PURPOSE: To evaluate the efficacy of reduced intensity conditioning (RIC) allogeneic transplant in 30 patients with poor-prognosis chronic lymphocytic leukemia (CLL) and/or high-risk molecular/cytogenetic characteristics" 01/01/1977 - "Studies on the local graft versus host reactivity of normal and chronic lymphocytic leukemia lymphocytes" 12/01/2007 - "We identified 19 persons with B-cell chronic lymphocytic leukemia (CLL) who received genetically identical twin blood cell or bone marrow transplants after high-dose conditioning" 11/01/2005 - "Chronic lymphocytic leukemia: to transplant or not to transplant.." 07/01/2004 - "Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia." Order ALL the reference details at left...
3.	Splenectomy 10/01/1992 - "PURPOSE: To assess the efficacy of splenectomy in the treatment of refractory cytopenias associated with advanced chronic lymphocytic leukemia (CLL)" 01/01/1997 - "These patients would be suitable for a randomized study to establish definitively the role of splenectomy in chronic lymphocytic leukemia." 11/01/2003 - "Subtotal splenectomy for the treatment of chronic lymphocytic leukemia." 09/01/1997 - "Role of splenectomy in chronic lymphocytic leukemia." 01/01/1997 - "CONCLUSION: Splenectomy can be performed with modest morbidity, mortality, and resource utilization in patients with advanced chronic lymphocytic leukemia and significant cytopenias" Order ALL the reference details at left...
4.	Stem Cell Transplantation 05/01/2003 - "Allogeneic stem cell transplantation (SCT) using reduced-intensity conditioning (RIC) has potential to be a promising treatment of aggressive chronic lymphocytic leukemia (CLL)" 10/01/2006 - "Predictors of improved progression-free survival after nonmyeloablative allogeneic stem cell transplantation for advanced chronic lymphocytic leukemia." 07/01/2008 - "Quantitative MRD monitoring identifies distinct GVL response patterns after allogeneic stem cell transplantation for chronic lymphocytic leukemia: results from the GCLLSG CLL3X trial." 04/01/2000 - "The objective of this study was to describe the outcome of allogeneic stem cell transplantation (alloSCT) in a series of patients with B cell chronic lymphocytic leukemia (B-CLL)" 02/01/1999 - "Stem-cell transplantation in chronic lymphocytic leukemia: the time for designing randomized studies has arrived." Order ALL the reference details at left...
5.	Transplantation (Transplant Recipients) 01/01/2004 - "Transplantation strategies in chronic lymphocytic leukemia: current concepts of the German CLL Study Group and the EBMT." 12/01/2007 - "Genetically identical twin transplantation for chronic lymphocytic leukemia." 10/01/2007 - "Positive selection and transplantation of autologous highly purified CD133(+) stem cells in resist