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Tuberculoid Leprosy

A principal or polar form of LEPROSY in which the skin lesions are few and are sharply demarcated. Peripheral nerve involvement is pronounced and may be severe. Unlike lepromatous leprosy (LEPROSY, LEPROMATOUS), the lepromin test is positive. Tuberculoid leprosy is rarely a source of infection to others.
Also Known As:
Leprosy, Tuberculoid; Leprosies, Macular; Leprosies, Neural; Leprosies, Tuberculoid; Macular Leprosies; Macular Leprosy; Neural Leprosies; Neural Leprosy; Tuberculoid Leprosies; Leprosy, Macular; Leprosy, Neural
Networked: 280 relevant articles (9 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Erythema Nodosum
2. Pulmonary Tuberculosis
3. Lepromatous Leprosy
4. Leprosy (Hansen's Disease)
5. Paucibacillary Leprosy

Experts

1. Sarno, Euzenir N: 6 articles (01/2016 - 09/2005)
2. Modlin, Robert L: 3 articles (05/2020 - 04/2007)
3. Geluk, Annemieke: 3 articles (01/2018 - 12/2012)
4. Saini, Chaman: 3 articles (01/2018 - 01/2013)
5. Ferreira, Helen: 3 articles (11/2017 - 03/2014)
6. Antunes, Sérgio L G: 3 articles (03/2015 - 01/2011)
7. Dockrell, H M: 3 articles (04/2002 - 10/2000)
8. Kelly-Scumpia, Kindra M: 2 articles (05/2020 - 01/2016)
9. Ochoa, Maria T: 2 articles (05/2020 - 01/2016)
10. Pellegrini, Matteo: 2 articles (05/2020 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tuberculoid Leprosy:
1. Proteins (Proteins, Gene)FDA Link
2. AntigensIBA
3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
4. Rifampin (Rifampicin)FDA LinkGeneric
5. SilverIBA
6. Ointments (Pastes)IBA
7. Inosine Monophosphate (IMP)IBA
8. Clofazimine (Lamprene)FDA Link
9. LeprominIBA
10. DapsoneFDA Link

Therapies and Procedures

1. Therapeutics
01/01/1990 - "Histological changes in tuberculoid leprosy after fixed duration multidrug therapy for six months."
04/01/1959 - "[Tuberculoid leprosy with old and deep ulceration of the heel cured by curettage and suture combined with medical therapy]."
08/28/1993 - "Our main findings were that: in both lepromatous and tuberculoid leprosy nerve damage increased distally, culminating in total destruction of dermal nerves and sensory nerve endings; after the therapy-related decrease of inflammation large-scale nerve regeneration took place; and that regenerating axons persisted for decades and in tuberculoid leprosy they might reach the subcutaneous fat of the plantar skin. "
06/01/1990 - "We have assessed the natural killer (NK) cell-mediated cytotoxicity and antibody-dependent cellular cytotoxicity (ADCC) in the peripheral blood lymphocytes (PBL) from untreated lepromatous leprosy (LL) patients, LL patients on multidrug therapy (MDT) with favorable responses (MDT-R), LL patients clinically classified as nonresponders to MDT (MDT-NR), treated tuberculoid leprosy (TT) patients, and healthy donors. "
06/01/1993 - "A total of 49 patients with paucibacillary leprosy (PB) who completed multidrug therapy (MDT) between 1985 and 1990 were analysed retrospectively for efficacy and complications; 20 (40.8%) patients had borderline-tuberculoid (BT), 13 (26.5%) had tuberculoid (TT), 1 (2.1%) had indeterminate (I) and 15 (30.0%) had pure neural (N) leprosy; 26 patients (76.5% of 34 non-neural leprosy) were skin biopsied for histological cure before MDT was stopped. "
2. Curettage
3. Drug Therapy (Chemotherapy)
4. Sutures (Suture)
5. Highly Active Antiretroviral Therapy (HAART)