|1.||Nephrotic Syndrome (Syndrome, Nephrotic)
|3.||Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal)
|4.||IGA Glomerulonephritis (IGA Nephropathy)
|1.||Ronco, Pierre: 37 articles (10/2015 - 11/2003)|
|2.||Debiec, Hanna: 35 articles (10/2015 - 06/2002)|
|3.||Remuzzi, Giuseppe: 19 articles (10/2015 - 05/2002)|
|4.||Beck, Laurence H: 19 articles (08/2015 - 07/2009)|
|5.||Hofstra, Julia M: 17 articles (01/2016 - 08/2008)|
|6.||Wetzels, Jack F M: 17 articles (06/2015 - 02/2006)|
|7.||Salant, David J: 16 articles (12/2014 - 04/2002)|
|8.||Fervenza, Fernando C: 14 articles (02/2015 - 05/2004)|
|9.||Cybulsky, Andrey V: 14 articles (11/2013 - 09/2002)|
|10.||Ruggenenti, Piero: 12 articles (10/2015 - 09/2002)|
|1.||Chlorambucil (Leukeran)FDA Link
11/01/1999 - "We conclude that steroid therapy alone, or associated with chlorambucil, is effective in patients with stage II to III membranous nephropathy. "
01/01/1983 - "Controlled trial of monthly alternated courses of steroid and chlorambucil for idiopathic membranous nephropathy."
01/01/2009 - "Efficacy and safety of low-dose chlorambucil in nephrotic patients with idiopathic membranous nephropathy."
01/01/2001 - "Severe bone marrow failure associated with the use of alternating steroid with chlorambucil in lupus membranous nephropathy in Chinese."
06/01/1996 - "Complete remission of nephrotic syndrome after steroid-chlorambucil in a previous failed short-term steroidal treatment of a primary membranous nephropathy."
|2.||rituximab (Mabthera)FDA Link
12/01/2010 - "It was postulated that in patients with membranous nephropathy (MN), four weekly doses of Rituximab (RTX) would result in more effective B cell depletion, a higher remission rate, and maintaining the same safety profile compared with patients treated with RTX dosed at 1 g every 2 weeks. "
04/01/2008 - "Four membranous glomerulonephritis patients achieved sustained remission with rituximab therapy. "
09/01/2007 - "Thus, B cell titrated as effectively as standard rituximab treatment achieves B cell depletion and idiopathic membranous nephropathy remission but is fourfold less expensive, allowing for more than 10,000 euros, approximately $13,000 in savings per patient. "
06/01/2013 - "B cell-targeted immunosuppression with rituximab as primary treatment or when conventional therapy is contraindicated or unsuccessful can induce remission in idiopathic membranous nephropathy (IMN). "
08/01/2012 - "Rituximab in membranous nephropathy: is it a first-line treatment?"
|3.||Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/01/1993 - "We conclude that steroid and cyclophosphamide every other month is highly effective in achieving remission in patients with membranous nephropathy."
07/01/2001 - "Cyclophosphamide is effective in the treatment of patients with idiopathic membranous nephropathy and deterioration of renal function. "
04/01/2002 - "While lupus membranous nephropathy has attracted limited study, preliminary work suggests a role for cyclophosphamide. "
10/01/1987 - "A controlled trial of cyclophosphamide in patients with membranous glomerulonephritis."
12/01/1974 - "Controlled trial of cyclophosphamide in idiopathic membranous nephropathy."
|4.||Cyclosporine (Ciclosporin)FDA LinkGeneric
03/01/2002 - "A major development is the demonstration in a randomized study that cyclosporin A is effective in membranous nephropathy. "
01/01/1992 - "The survey of open trials of Cyclosporin (CyA) in membranous nephropathy demonstrates that low dose CyA (4-5 mg/kg/day) given for a long term therapy (more than a year) can induce remission in 60-70% of the patients. "
11/01/2006 - "Cyclosporine A (CyA) has been shown to be effective in membranous nephropathy (MN). "
12/01/2001 - "To evaluate the efficacy of cyclosporin A (CSA) in the treatment of idiopathic membranous nephropathy (IMN), a prospective controlled clinical study was performed. "
01/01/2010 - "The possibility of a spontaneous remission of membranous nephropathy, etc. was considered, but a relapse occurred when the amount of cyclosporine was reduced. "
|5.||Immunoglobulin G (IgG)IBA
03/01/1991 - "Preliminary results of the efficacy of high-dose intravenous human IgG in patients with biopsy-confirmed idiopathic membranous nephropathy (IMGN) were reported. "
05/01/1984 - "Nine of 15 rhesus-D positive patients with membranous nephropathy had delayed clearance of the IgG cells and the defect did not correlate with disease activity. "
06/01/2013 - "There are no studies addressing the IgG subclass distribution across different stages of membranous glomerulonephritis. "
01/01/2005 - "Urinary excretion of beta2-microglobulin and IgG predict prognosis in idiopathic membranous nephropathy: a validation study."
11/01/2002 - "This study also shows the selective significance of IgG4 in MN, but not in MLN, another form of membranous glomerulopathy."
03/01/2002 - "When steroids and immunosuppressive drugs were the only available pharmacological agents used to treat membranous nephropathy, nephrologists were polarized into two groups, those supporting therapy on the basis of the results achieved in controlled trials and those opposed to therapy who contended that the side-effects of therapy were too severe to consider in a disease with a relatively benign course. "
01/01/1991 - "In membranous nephropathy, the data strongly support a positive effect in this disorder, but there have been no control trials thus far to indicate the risk-benefit ratio, the need for adjunctive therapy such as steroids, or what to expect in terms of time to response or duration of response. "
01/01/2015 - "7) The identification of clinical and/or laboratory signs suggestive of proliferative or membranous glomerulonephritis should indicate an immediate implementation of specific therapy, including steroids and an immunosuppressive agent, even though histological confirmation is not possible. "
01/01/2010 - "The use of steroids to treat membranous glomerulonephritis, therefore, might produce unpredictable results, depending on whether suppression of the systemic immune response or inflammatory events within the kidney is more important in a particular patient."
05/01/2000 - "[Treatment of idiopathic membranous glomerulonephritis with steroids and immunosuppressors]."
|7.||Prednisolone (Predate)FDA LinkGeneric
01/01/1994 - "Prednisolone and immunosuppressive agent were most effective in these patients with membranous nephropathy. "
02/01/1990 - "We have assessed the medium-term effect of a short course of high-dose, alternate-day prednisolone on adult nephrotic patients with membranous nephropathy, using a randomized, prospective, double-blind, controlled trial. "
01/01/2005 - "She was diagnosed as membranous nephropathy by needle renal biopsy, and treated with prednisolone. "
06/01/2001 - "He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone. "
01/01/1994 - "Increased FCsDex tended to normalize during prednisolone treatment in membranous nephropathy. "
|8.||Prednisone (Sone)FDA LinkGeneric
12/13/1979 - "We conclude that a short course of alternate-day prednisone therapy was beneficial in our group of patients with idiopathic membranous nephropathy."
01/26/1989 - "We conducted a prospective randomized study in which patients with biopsy-confirmed idiopathic membranous nephropathy were assigned to receive either a six-month course of prednisone given on alternate days (45 mg per square meter of body-surface area; n = 81) or no specific treatment (n = 77). "
12/13/1979 - "A controlled study of short-term prednisone treatment in adults with membranous nephropathy. "
01/01/2004 - "A percutaneous kidney biopsy showed a stage I-lI membranous nephropathy and an eight-week course with oral prednisone was initiated without response. "
07/27/1989 - "Prednisone in the treatment of idiopathic membranous nephropathy."
04/01/2007 - "Follow-up at 30 months showed consistent remission of membranous nephropathy, demonstrated by a serum creatinine level of 150 mumol/L, microalbuminuria of 107 mg/24 h and normal albuminemia of 43.7 g/l. "
03/02/2013 - "We recruited patients (18-75 years) with biopsy-proven idiopathic membranous nephropathy, a plasma creatinine concentration of less than 300 μmol/L, and at least a 20% decline in excretory renal function measured in the 2 years before study entry, based on at least three measurements over a period of 3 months or longer. "
05/01/1991 - "Eleven consecutive patients with biopsy-proven membranous glomerulonephritis and rising plasma creatinine levels over at least 6 months. "
01/01/1987 - "Highest urine protein losses and 24-hour urine protein/creatinine ratios developed in dogs with membranous glomerulonephritis. "
01/01/1981 - "All immunized rats developed membranous glomerulonephritis but creatinine clearance did not decrease. "
|10.||Adrenal Cortex Hormones (Corticosteroids)IBA
07/01/2003 - "Good results with cytotoxic drugs, often associated with corticosteroids, also have been reported in progressive membranous nephropathy. "
06/01/1995 - "Corticosteroids or alkylating therapy did not improve renal survival in idiopathic membranous glomerulopathy. "
04/15/1992 - "Alternate-day treatment with corticosteroids is often recommended for nephrotic patients with idiopathic membranous nephropathy, but this approach has not been proved beneficial. "
05/01/1982 - "Membranous glomerulonephropathy: there is no significant effect of treatment with corticosteroids."
01/01/2003 - "Oral corticosteroids with hemodialysis allowed to obtain complete regression of ARF and partial remission of membranous glomerulonephritis. "
|1.||Transplantation (Transplant Recipients)
01/01/2009 - "Preexisting membranous nephropathy itself may show remission after transplantation into the recipient to achieve successful results, however, long-term careful observation of both the donor and recipient is required."
08/01/2009 - "Pre-existing membranous nephropathy itself might show remission after transplantation in the recipient. "
07/01/1977 - "This study reports the clinical and pathological findings in a patient with recurrent membranous glomerulonephritis following transplantation of an HLA-identical kidney. "
07/01/2014 - "Transplantation offers a unique ethical experimental context in which to explore the genetic contribution to recurrent autoimmune membranous nephropathy. "
03/01/2013 - "The management of membranous glomerulopathy in allogeneic stem cells transplantation: updated literature."
07/01/2004 - "Development of malignancy after treatment of idiopathic membranous nephropathy."
08/01/1992 - "Patients with membranous nephropathy showed a significant elevation of Leu 2a+DR+ cells after treatment with PSL. "
02/01/2004 - "In both cases, renal biopsy revealed membranous nephropathy (MN), and the patients achieved remission after treatment with prednisolone. "
08/01/1998 - "Three anti-HCV-positive patients with membranous nephropathy did not show significant remission of nephrotic proteinuria after treatment with interferon-alpha. "
06/01/2010 - "We describe a case of lumbar tuberculosis associated with simultaneous membranous nephropathy and interstitial nephritis, in which recovery of renal function occurred after treatment with steroids in addition to antituberculosis agents."
04/01/2015 - "We excluded all post transplant biopsies, and biopsies showing diabetic glomerulopathy, membranoproliferative glomerulopathy, membranous glomerulopathy, and biopsies where no electron microscopy or immunofluorescent studies were done. "
10/01/2015 - "Membranous nephropathy was the most frequent cause of post-transplant RGN. "
02/01/2013 - "De novo postallogeneic hematopoietic stem cell transplant membranous nephropathy."
01/01/2013 - "We accessed the Irish renal transplant database to identify patients with biopsy-proven idiopathic membranous nephropathy in receipt of a renal transplant between 1982 and 2010. "
01/01/2013 - "The natural history of idiopathic membranous nephropathy and recurrent disease in transplants is variable. "
11/01/2008 - "This case report describes a probably spontaneous clinical remission of a recurrent membranous nephropathy after renal transplantation. "
11/01/2008 - "Recurrence and spontaneous remission of membranous nephropathy after renal transplantation."
06/01/2008 - "Recurrent idiopathic membranous nephropathy after kidney transplantation: a surveillance biopsy study."
07/01/1977 - "This case confirms that membranous glomerulonephritis may occasionally recur following renal transplantation and demonstrates that immunofluorescence and electron microscopic studies may be necessary to distinguish recurrent, membranous glomerulonephritis from the membranous changes frequently seen with chronic rejection. "
12/01/2012 - "De novo membranous nephropathy (MN) is an uncommon complication of kidney transplantation, which shows histological findings similar to those seen in recurrent MN, but with some distinct differences. "
|5.||Homologous Transplantation (Allograft)
01/01/2012 - "Remission of de novo membranous nephropathy in a kidney allograft recipient: a case report."
12/01/2013 - "Membranous glomerulopathy in renal allograft: an ultrastructural study of 17 cases."
12/01/2014 - "Membranous nephropathy transplanted in the donor kidney: observations of resolving glomerulopathy in serial allograft biopsies."
12/01/2013 - "To assess the diagnostic refinement supplied by electron microscopy to conventional light and immunofluorescence procedures the authors reviewed 17 cases of electron microscopy-confirmed membranous glomerulonephritis in kidney allograft. "
12/01/2013 - "Membranous glomerulopathy is a common complication of renal allograft. "