|4.||Body Weight (Weight, Body)
|5.||Type 2 Diabetes Mellitus (MODY)
|1.||Astrup, Arne: 55 articles (09/2015 - 05/2002)|
|2.||le Roux, Carel W: 45 articles (10/2015 - 01/2006)|
|3.||Klein, Samuel: 43 articles (07/2015 - 06/2002)|
|4.||Gagner, Michel: 38 articles (11/2015 - 04/2002)|
|5.||Reinehr, Thomas: 35 articles (05/2015 - 01/2004)|
|6.||Wadden, Thomas A: 34 articles (06/2015 - 10/2002)|
|7.||Clifton, Peter M: 34 articles (01/2015 - 04/2002)|
|8.||Astrup, A: 34 articles (01/2015 - 03/2000)|
|9.||Bray, George A: 33 articles (12/2015 - 06/2002)|
|10.||Lee, Wei-Jei: 33 articles (10/2015 - 12/2003)|
|1.||Insulin (Novolin)FDA Link
05/01/2004 - "In agreement with these actions, it has been shown to be highly effective in the treatment of Type 2 diabetes, causing marked improvements in glycaemic profile, insulin sensitivity and beta-cell performance, as well as weight reduction. "
05/01/2000 - "The blood pressure-lowering effect of weight loss is most likely a result of an improvement in insulin sensitivity and a decrease in sympathetic nervous system activity and occurs independent of salt restriction. "
10/01/1981 - "Following a prolonged fast, obese diabetics show substantial improvement in most parameters of insulin function--an effect which is to some degree independent of weight loss; long-term remission of diabetes may be possible if the benefits of therapeutic fasting are conserved by appropriate eumetabolic measures."
03/01/2002 - "Improved aerobic fitness appeared to be the major difference between the two intervention groups, although weight loss and diet composition may have also played an important role in determining insulin sensitivity."
02/01/1996 - "In obese non-diabetic subjects the improvement in insulin sensitivity induced by weight loss was not accompanied by marked changes in skeletal muscle fiber composition or capillary density. "
|2.||Glucose (Dextrose)FDA LinkGeneric
09/01/2002 - "Higher preoperative fasting glucose best predicted the decrease in TG; improved HOMA %S with weight loss correlated best with HDL-C. "
11/01/2010 - "This improvement in glucose metabolism occurs before marked weight loss in patients undergoing bypass procedures, suggesting a direct effect on the hormonal control of glucose metabolism."
08/01/2009 - "Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss."
03/01/1990 - "After a 30-kg weight loss their glucose and lipid profiles were markedly improved but the thermic effect of glucose was still lower than that of the control subjects (4.2%, p less than 0.001). "
01/01/2011 - "Our study shows that LSG is effective in producing a significant and sustained weight loss and improving glucose homeostasis in severely obese T2DM patients."
06/01/2005 - "The small number of side effects and complications, the excellent weight loss and the recovery of most co-morbidity leads to a great improvement in quality of life."
07/01/2014 - "Revision of a failed RYGB or conversion of a VBG to a RYGB provides less weight loss and a higher complication rate than primary RYGB but provides an excellent opportunity for co-morbidity remission."
11/01/2007 - "All co-morbidities resolved completely with the weight loss. "
09/01/2015 - "We have observed good results in terms of weight loss and co-morbidity improvement/remission. "
07/01/2015 - "At 3 years, despite less favorable impact on weight than for younger patients, LRYGB provided significant weight loss and remission of co-morbidities for patients aged > 60 years. "
|4.||orlistat (Xenical)FDA Link
01/01/1998 - "Orlistat, an inhibitor of pancreatic lipases, has proven effective for weight reduction in obese patients. "
01/01/2006 - "The weight loss was significantly greater in the orlistat group than in the placebo group for the entire study period (P < 0.001). "
12/01/2005 - "Orlistat-treated patients achieved significantly greater weight loss at the study end than placebo-treated patients (-5.4 vs. -2.4 kg; P<0.0001). "
01/01/2003 - "In randomized, controlled trials of up to 2 years' duration, orlistat plus a hypocaloric diet produced significantly greater weight loss than placebo (P < 0.001). "
10/01/2000 - "In a series of 1- and 2-yr randomized, placebo-controlled trials of obese subjects, treatment with orlistat in combination with a mildly calorie-restricted diet consistently produced significantly greater mean weight loss than diet alone. "
|5.||sibutramine (Meridia)FDA Link
01/01/2003 - "The efficacy of sibutramine for inducing initial weight loss and the subsequent maintenance of weight loss is well proven in short- and long-term clinical trials of up to 2 years' duration. "
10/01/2007 - "However, there is some controversy as to whether weight loss is beneficial for health, and large clinical outcome trials such as the Look-AHEAD (Action for Health in Diabetes) trial or the SCOUT (Sibutramine Cardiovascular Outcomes Trial) study are currently ongoing. "
01/01/2007 - "This study confirmed that sibutramine significantly enhances the effect of diet on weight loss, BMI and waist circumference reduction, and showed a significant improvement of QoL."
04/01/2000 - "Mean weight reduction from baseline was statistically significantly greater with sibutramine than with placebo at every measurement and at the end of the study (2.4 vs. 0.1 kg at week 12; p < 0.001; intent-to-treat). "
08/01/2008 - "Sibutramine appears to be safe and effective in producing clinically significant weight loss for up to 1 year. "
10/01/1986 - "The most improved group exhibited the following mean changes: weight loss of 9.2 kg, reductions in blood pressure of 12.9/8.8 mm Hg, improvement in aerobic capacity of 33%, reduction in serum cholesterol of 0.45 mmol/liter, and reduction in current overall CHD risk of 41%. "
05/01/2008 - "The main results show that Intervention group (I) had a statistically significant improvement compared to Usual Care (UC) in the assumption of recommended quantity of fruit and vegetables (78.4% I vs 38.8% UC p=0.005), in the weight loss (weight loss > al 5% in subjects with BMI > 25 kg/m2) (16.5% I vs 6.8% UC p=0.005), in blood pressure control both in people specifically treated with drugs and untreated (respectively 52% I vs 35% UC p=0.04 and 65% Ivs 45% UC p=0.02), in reaching the European target for total cholesterol (Total Cholesterol < 5.0 mmol/l) during the study year (from 21.9% to 35.8% (I) absolute increase 12.7% (p=0.025) vs from 33% to 32.2% (UC)). "
06/01/2007 - "Weight loss was associated with significant improvement in systolic blood pressure (-11 +/- 15 mmHg), diastolic blood pressure (-5 +/- 8 mmHg), and cholesterol (-0.7 +/- 1.3 mmol/l), even after adjustment for the use of medications (P < 0.001). "
05/01/1995 - "At follow-up, high active patients maintained significantly greater weight loss, had a lower percent regain and a significantly greater decrease in total cholesterol (P < 0.05) than less active patients. "
06/01/1989 - "At the first posttest measure, the intervention group compared to the control group had a significantly greater decrease in blood cholesterol, a greater gain in aerobic fitness, a greater weight loss, and a greater decrease in body fat. "
|7.||Non-alcoholic Fatty Liver DiseaseIBA
07/01/2013 - "Weight loss is an effective treatment for children with nonalcoholic fatty liver disease (NAFLD), but it is extremely difficult to achieve outside of an intensive weight management program. "
01/01/2011 - "The best treatment of AFLD/ASH is to stop drinking, and the most effective first-line therapeutic option for NAFLD/NASH is non-pharmacologic lifestyle interventions through a multidisciplinary approach including weight loss, dietary changes, physical exercise, and cognitive-behavior therapy."
05/01/2012 - "Weight loss of 2.7±5.0kg was significantly associated with NAFLD remission. "
07/01/2008 - "Lifestyle intervention with diet and increased physical activity induces weight loss and is associated with a significant improvement in liver histology and laboratory abnormalities in pediatric NAFLD. "
03/01/2008 - "Weight loss appears to improve NAFLD, and dietary advice and lipid-lowering drugs may be beneficial for patients with NAFLD and dyslipidaemia even if weight loss is not achieved. "
|8.||Metformin (Glucophage)FDA LinkGeneric
08/01/2004 - "Modest weight reduction was found in all treatment groups, with the most significant reduction occurring with the combination of metformin and lifestyle intervention. "
06/01/2015 - "The combination of GSK2041706 and metformin at 100 mg/kg caused a significantly greater weight loss than the projected additive weight loss of 11.8%. "
04/01/2012 - "Throughout the unblinded follow-up, weight loss remained significantly greater in the metformin group than in the placebo group (2.0 vs. 0.2%, P < 0.001), and this was related to the degree of continuing metformin adherence (P < 0.001). "
06/01/2004 - "Metformin was more effective in promoting weight loss in patients with type 2 diabetes, although TZDs may decrease visceral fat levels. "
07/01/2015 - "Metformin intervention improved the semen parameters, possibly due to its effects on weight loss, increased testicular weight, reduced testicular cell apoptosis, and resulted in restoration of hormonal homeostasis and correction of metabolic disorder."
05/01/1998 - "Exogenous administration of leptin to ob/ob mice leads to a significant improvement in reproductive and endocrine status as well as reduced food intake and weight loss. "
05/04/2007 - "Blocking central IL1 signaling also did not alter the re-feeding response to a prolonged fast, yet was entirely effective in preventing the anorexic effect of exogenously administered leptin (2 mg/kg ip, cumulative food intake at 18 h AdV-IL1ra 30.5+/-1.1 g vs. VEH 26.4+/-1.7 g, p<0.05) and prevented leptin-induced weight loss (AdV-IL1ra -0.1+/-1.3 g vs. VEH -2.7+/-1.9 g, p<0.05). "
12/01/2010 - "Weight loss (average 50% excess weight) was associated with a 14% improvement in PWV (P = 0.03), and with reductions in serum leptin levels (P < 0.01). "
04/01/2006 - "It has been shown that the administration of leptin in congenital leptin deficiency that there was improvement in satiety and weight loss. "
11/01/2001 - "Administration of leptin to ob/ob mice led to improved reproduction as well as reduced feed intake and weight loss. "
|10.||exenatide (Byetta)FDA Link
03/01/2009 - "In clinical trials, exenatide QW significantly improved glycemic control, resulted in patient weight loss, and was well tolerated in patients with T2DM. "
01/01/2013 - "Clinical use of Exenatide is associated with significant improvement in glycemic control and major weight loss (8.3±4.3 kg at 1 year) in obese subjects with type 2 diabetes. "
05/01/2008 - "An 82-week, open-label extension trial has shown that exenatide is well tolerated and that the benefits, including improved glycemic control, weight loss, and mitigation of cardiovascular risk factors, are sustained."
03/01/2015 - "Long-term once weekly exenatide treatment was generally well tolerated with sustained glycemic improvement, weight reduction, and improved markers of cardiovascular risk in patients with type 2 diabetes. "
01/01/2013 - "Overall, both cohorts achieved improved glycemic control, which was accompanied by a mean weight loss in the exenatide BID cohort."
04/01/2012 - "While most patients after bariatric surgery experienced sustained weight loss and improved metabolism, small scale studies have shown weight regain and diabetes relapse, the mechanisms of which remain unknown."
09/01/2007 - "Meta-analyses mainly based on case series data as well as controlled studies confirm that bariatric surgery is highly effective in obtaining weight reduction in morbidly obese patients up to 60% of the excess weight, along with resolution of preoperative diabetes in more than 75% of cases. "
02/01/2014 - "Bariatric surgery is the most effective treatment for weight loss and glycaemic control. "
10/21/2013 - "Although a remarkable effect of bariatric surgery is the profound and durable resolution of type 2 diabetes clinical manifestations, little is known about the difference among various weight loss surgical procedures on diabetes remission. "
07/01/2013 - "Bariatric surgery is the most effective treatment for achieving a significant weight loss. "
|2.||Gastric Bypass (Roux-en-Y Gastric Bypass)
09/01/2013 - "We conclude that gastric bypass surgery yields significant weight loss for most patients in Veterans Affairs Medical Centers, but is particularly effective for female and Caucasian patients."
03/01/2013 - "Among all types of intervention, the most frequently used is Roux-en-Y gastric bypass, an intervention both restrictive and malabsorptive, which leads to best results in weight loss. "
12/01/2012 - "Roux-en-Y Gastric Bypass is the gold standard procedure for weight loss surgery and is the most commonly performed bariatric operation in the United States. "
01/01/2009 - "The %EBL was the best method to report weight loss and the improvement in MS in morbidly obese subjects after Roux-en-Y gastric bypass."
10/01/2007 - "Laparoscopic gastric bypass, currently the most popular surgical method for bariatric therapy, have proved to be effective in weight loss, but some matters regarding its long-term efficacy for super-obese patients (BMI >50 kg/m2) have arisen. "
01/01/2005 - "Research studies have found that interventions that combine a low-calorie diet, increased physical activity, and behavior therapy are most effective for weight loss and maintenance. "
11/01/2000 - "Low-calorie diets, protein-sparing modified fasts, and modified-carbohydrate diets seem to be the most effective for patient compliance, and modified-carbohydrate plans are probably necessary for maintenance of the weight loss."
01/01/2005 - "These results were minimized by weight loss in the comparison group, however, and examination of individual study arms revealed that multicomponent interventions including very low calorie diets or low calorie diets may hold promise for achieving weight loss in adults with type 2 diabetes."
11/15/2004 - "These results were minimized by weight loss in the comparison group, however, and examination of individual study arms revealed that multicomponent interventions, including very low-calorie diets or low-calorie diets, may hold promise for achieving weight loss in adults with type 2 diabetes."
06/01/2006 - "Liver size appears reduced and surgical access improved following preoperative weight loss with Optifast Very Low Calorie Diet (VLCD). "
|4.||Drug Therapy (Chemotherapy)
01/01/2005 - "Most pharmacotherapies have demonstrated significantly greater weight loss in patients on active treatment than those receiving placebo in short-term (<or=1 year) randomised controlled trials of pharmacological treatment in conjunction with a calorie-controlled diet or lifestyle intervention. "
12/01/2001 - "When medically indicated, pharmacotherapy may be used for weight loss, but pharmacotherapy appears to be most effective when used in combination with modifications of both eating and exercise behaviors. "
12/20/2006 - "Univariate analysis indicated that gender (P=0.0395), stage (P= 0.0000 ), LDH (P=0.0000), operation (P=0.0029), weight loss (P=0.0000) and the efficacy of first-line chemotherapy (P=0.0000) significantly influenced survival in SCLC. "
11/01/1980 - "Patients on chemotherapy did not have a significantly greater incidence of aversions, weight loss, decreased appetite, or early satiety than patients not receiving chemotherapy. "
01/01/2014 - "Patients with weight loss>5% during chemotherapy tended to have shorter progression-free survival (6.0 months vs. 8.1 months; p=0.062) and overall survival (8.6 months vs. 18.0 months; p=0.022), and if weight loss was reversed during chemotherapy, survival rates improved. "
02/01/2014 - "In adolescents, laparoscopic sleeve gastrectomy is an excellent option to provide excess weight loss and remission of comorbid conditions without long-term malabsorptive risks. "
01/01/2014 - " RCT comparing laparoscopic isolated sleeve gastrectomy (LISG) versus LAGB found greater improvement in weight-loss outcomes following LISG at three years follow-up (very low quality evidence). "
04/01/2012 - "Laparoscopic sleeve gastrectomy (LSG) as a primarily restrictive bariatric surgical procedure has been shown to be effective in producing marked weight loss. "
03/01/2012 - "Laparoscopic DJB with sleeve gastrectomy is safe and effective in achieving durable weight loss and excellent resolution of comorbidities. "
05/01/2008 - "Good results obtained after laparoscopic sleeve gastrectomy (LSG), in terms of weight loss and morbidity, have been reported in few recent studies. "