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Myocardial Reperfusion Injury

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Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.

Also Known As:

Injury, Myocardial Reperfusion; Myocardial Ischemic Reperfusion Injury; Injuries, Myocardial Reperfusion; Myocardial Reperfusion Injuries; Reperfusion Injuries, Myocardial; Reperfusion Injury, Myocardial

Networked: 343 relevant articles (27 outcomes, 60 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Ischemia
2.	Thrombosis (Thrombus)
3.	Shock
4.	Myocardial Infarction
5.	Atherosclerosis (Atheroma)

Experts

1.	Das, Dipak K: 7 articles (09/2008 - 02/2006)
2.	Yellon, Derek M: 4 articles (05/2009 - 09/2003)
3.	Sellke, Frank W: 4 articles (03/2009 - 10/2002)
4.	Bianchi, Cesario: 4 articles (03/2009 - 10/2002)
5.	Zingarelli, Basilia: 4 articles (11/2007 - 02/2002)
6.	Hake, Paul W: 4 articles (11/2007 - 02/2002)
7.	Gao, Feng: 3 articles (04/2010 - 02/2002)
8.	Gao, Erhe: 3 articles (03/2009 - 05/2002)
9.	Wong, Hector R: 3 articles (11/2007 - 02/2002)
10.	O'Connor, Michael: 3 articles (11/2007 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myocardial Reperfusion Injury:

1.	Superoxide DismutaseIBA 01/01/1993 - "The efficacy of superoxide dismutase administered using synchronized coronary venous retroperfusion (SRP) on the extent of myocardial reperfusion injury was studied. " 01/01/1992 - "The efficacy of recombinant human extracellular-superoxide dismutase type C (EC-SOD C) on myocardial reperfusion injury was explored in hypothermically arrested rat hearts, as was its site of action. " 02/18/2000 - "The role of Cu/Zn-superoxide dismutase (SOD) in myocardial ischemic reperfusion injury was studied by using a mouse model with targeted disruption of the mouse Sod I gene. " 01/01/1992 - "Effects of recombinant human extracellular-superoxide dismutase type C on myocardial reperfusion injury in isolated cold-arrested rat hearts." 12/01/1990 - "We also observed the protective effect of superoxide dismutase (SOD) on myocardial ischemic-reperfusion injury. " Order ALL the reference details at left...
2.	OxygenIBA 12/01/1990 - "Many studies have provided indirect evidence that there is a relationship between oxygen free radical and myocardial ischemic-reperfusion injury. " 12/01/1991 - "Oxygen radical toxicity has been implicated in the pathogenesis of myocardial reperfusion injury. " 07/01/1991 - "Myocardial reperfusion injury may be due to biophysical changes (e.g., endothelial cell junctional separations), as well as biochemical mechanisms (e.g., oxygen free radical activity). " 12/01/1990 - "Oxygen free radical was at least one of the major cause of rat myocardial reperfusion injury observed in this experiment. " 09/01/2008 - "Pharmacological preconditioning with hyperbaric oxygen: can this therapy attenuate myocardial ischemic reperfusion injury and induce myocardial protection via nitric oxide?" Order ALL the reference details at left...
3.	Free RadicalsIBA 12/01/2004 - "Numerous investigators have reported the mechanisms underlying myocardial reperfusion injury such as generation of free radicals, disturbance in the intracellular ion homeostasis, and lack of energy for contraction. " 03/01/2003 - "Free radicals have been implicated in myocardial reperfusion injury. " 07/01/1994 - "1. Myocardial 'reperfusion injury' has been partly attributed to the production of free radicals which are cytotoxic towards cells. " 07/01/1994 - "BACKGROUND: Free radicals and lipid peroxidation have been suggested to play an important role in the pathophysiology of myocardial reperfusion injury. " 04/01/1994 - "The role of free radicals in myocardial reperfusion injury remains controversial. " Order ALL the reference details at left...
4.	Adenosine FDA LinkGeneric 02/01/1992 - "To determine the efficacy of very low doses of adenosine on myocardial reperfusion injury and whether its effect is receptor mediated, 78 rabbits underwent 30 minutes of left circumflex artery occlusion and 48 hours of reperfusion. " 07/01/2004 - "This study assessed whether adjunctive therapy with adenosine might prevent or attenuate the phenomenon of myocardial reperfusion injury. " 11/01/1991 - "The purpose of this study was to investigate the effects of various doses of adenosine administered intravenously on myocardial reperfusion injury in a model with poor collateral blood flow. " 07/01/2004 - "Adjunctive therapy with intracoronary infusion of adenosine during PCI prevents the occurrence of severe myocardial reperfusion injury and is associated with less infarct expansion." 07/01/2004 - "Multivariate analysis identified adjunctive therapy with adenosine as an independent protective determinant of myocardial reperfusion injury and of infarct expansion. " Order ALL the reference details at left...
5.	Hydroxyl RadicalIBA 04/01/1992 - "Several studies indicate the presence of hydroxyl radical (OH.) as well as its involvement in the myocardial reperfusion injury. " 01/04/1991 - "High-performance liquid chromatographic detection of hydroxylated benzoic acids as an indirect measure of hydroxyl radical in heart: its possible link with the myocardial reperfusion injury." 06/01/1989 - "We believe that superoxide anion, not hydroxyl radical, is the main OFR which is responsible for myocardial reperfusion injury. " 10/01/1987 - "The present study was designed to test the hypothesis that myocardial reperfusion injury might be reduced by administration of the iron chelator deferoxamine at the time of reflow, most likely by preventing hydroxyl radical formation. " 01/01/1999 - "Peroxynitrite and hydroxyl radical are reactive oxidants produced during myocardial reperfusion injury. " Order ALL the reference details at left...
6.	IronIBA 12/01/1994 - "The aim of this study was to determine whether a diet containing iron to a concentration of the recommended upper limit alters the degree of myocardial ischemic/reperfusion injury on rats and whether simultaneous antioxidant supplementation had any effect. " 05/01/2002 - "Time window of nitroxide effect on myocardial ischemic-reperfusion injury potentiated by iron." 02/01/1994 - "Exogenous intracellular, but not extracellular, iron augments myocardial reperfusion injury." 03/01/2003 - "In addition to these effects, important in atherosclerosis, ample experimental evidence suggests a role of iron in myocardial reperfusion injury. " 11/01/1996 - "Although previous studies have investigated the protective effect of iron chelators including deferoxamine (DFX) in myocardial reperfusion injury, there is little information regarding the role of iron chelation during oxidative stress produced by H2O2 on the heart. " Order ALL the reference details at left...
7.	CalciumIBA 12/01/1989 - "The protective effects of calcium antagonist and free radical scavenger against myocardial ischemic/reperfusion injury in the isolated rat heart." 04/15/2010 - "Calcium overload is one of the major causes for myocardial reperfusion injury, the present study was to investigate the role of intracellular calcium oscillations in the effects of reperfusion with low K(+) on rat myocytes. " 09/19/2004 - "Calcium (Ca2+) overload is an important pathophysiological factor in myocardial ischemic/reperfusion injury. " 05/02/1997 - "Interrelationship between cellular calcium homeostasis and free radical generation in myocardial reperfusion injury." 08/01/2002 - "BACKGROUND: Magnesium's effect on calcium ion concentrations may attenuate myocardial reperfusion injury. " Order ALL the reference details at left...
8.	Deferoxamine (Desferal)FDA LinkGeneric 01/01/1989 - "Early treatment with deferoxamine limits myocardial ischemic/reperfusion injury." 11/01/1996 - "Although previous studies have investigated the protective effect of iron chelators including deferoxamine (DFX) in myocardial reperfusion injury, there is little information regarding the role of iron chelation during oxidative stress produced by H2O2 on the heart. " 10/01/1987 - "The present study was designed to test the hypothesis that myocardial reperfusion injury might be reduced by administration of the iron chelator deferoxamine at the time of reflow, most likely by preventing hydroxyl radical formation. " 03/01/1991 - "CONCLUSIONS: These results demonstrate improved functional and metabolic recovery of myocardium treated with deferoxamine during ischemia, accompanied by a reduction in reperfusion-induced oxygen free-radical generation to the same degree as reflow treatment, confirming the importance of iron in the pathogenesis of myocardial reperfusion injury." 07/01/1987 - "A Langendorff isolated rat heart preparation was used to determine the effect of oxypurinol, a xanthine oxidase inhibitor, and deferoxamine, an iron binding agent, on the extent of myocardial reperfusion injury after 60 minutes of ischaemia. " Order ALL the reference details at left...
9.	Peroxynitrous Acid (Peroxynitrite)IBA 10/01/2002 - "These data support the pathogenic role of endogenously produced peroxynitrite and that FP-15 is effective in preventing myocardial reperfusion injury." 11/01/1997 - "Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart." 03/01/2009 - "Taken together, our data demonstrated that INO-4885 is a cardioprotective molecule that attenuates myocardial reperfusion injury by facilitating peroxynitrite decomposition and inhibiting NADPH oxidase-derived O2(.-) production." 01/01/1999 - "Peroxynitrite and hydroxyl radical are reactive oxidants produced during myocardial reperfusion injury. " 09/01/1997 - "Peroxynitrite and hydroxyl radical are reactive oxidants produced during myocardial reperfusion injury. " Order ALL the reference details at left...
10.	Superoxides (Superoxide)IBA 01/01/1991 - "Superoxide radicals are supposed to contribute to myocardial reperfusion injury. " 06/01/1989 - "We believe that superoxide anion, not hydroxyl radical, is the main OFR which is responsible for myocardial reperfusion injury. " 12/01/1992 - "The present study was designed to compare the efficacy of administration of the hydroxyl radical scavenger mannitol vs. that of the superoxide radical scavenger superoxide dismutase (SOD) in reducing myocardial reperfusion injury, and to test whether combined treatment with both agents would confer better tissue protection compared with either intervention alone. " 01/01/1985 - "Our results suggest that this reaction may be important in myocardial reperfusion injury since reoxygenation of ischemic myocardium results in a burst of xanthine oxidase-generated superoxide and hydrogen peroxide in proximity to cellular myoglobin." 01/01/1989 - "Harmful effects of some biochemically generated free radicals and oxidants, including superoxide anions (O2-), hydroxyl radical (OH.), hydrogen peroxide, hypochlorous acid, and hypohalite radical, on isolated cardiac myocytes were compared in an attempt to identify the exact nature of the free radicals/oxidants responsible for myocardial ischemic-reperfusion injury. " Order ALL the reference details at left...

Therapies and Procedures

1.	Induced Heart Arrest (Cardioplegia) 03/01/2007 - "LD cardioplegia and myocardial reperfusion did not attenuate the endothelial and neutrophil-mediated components of the CPB-induced inflammatory response, which may lead to myocardial reperfusion injury." 03/01/2004 - "Activity of these signal cascades may contribute to the increased pulmonary vascular permeability and myocardial reperfusion injury observed after cardiac surgery with cardioplegia and cardiopulmonary bypass. " 03/01/2004 - "CONCLUSIONS: Neutrophil-filtered blood cardioplegia/reperfusion significantly reduced clinical and biochemical indices of myocardial reperfusion injury after elective coronary revascularization with cardiopulmonary bypass." 06/01/2002 - "Therefore, we investigated the effect of sevoflurane on myocardial reperfusion injury after cardioplegic arrest with University of Wisconsin solution (UW), Bretschneider's cardioplegia (HTK), and St Thomas' Hospital solution (STH). " 11/09/1999 - "BACKGROUND: Various studies have reported that the administration of adenosine (ADO) in cardioplegia reduces myocardial ischemic injury, but this timing may not utilize ADO's potential against myocardial reperfusion injury. " Order ALL the reference details at left...
2.	Cardiopulmonary Bypass (Heart-Lung Bypass) 09/01/2005 - "BACKGROUND: The purpose of this study is to investigate the effect of cardiopulmonary bypass (CPB) temperature on myocardial reperfusion injury, oxidative stress, and inflammatory response in pediatric open heart surgery. " 01/01/1996 - "Attenuation of cardiopulmonary bypass-derived inflammatory reactions reduces myocardial reperfusion injury in cardiac operations." 02/01/1992 - "Cardiopulmonary bypass is known to cause neutrophil activation, and activated neutrophils appear to be of importance in myocardial reperfusion injury. " 03/01/2004 - "Activity of these signal cascades may contribute to the increased pulmonary vascular permeability and myocardial reperfusion injury observed after cardiac surgery with cardioplegia and cardiopulmonary bypass. " 03/01/2004 - "CONCLUSIONS: Neutrophil-filtered blood cardioplegia/reperfusion significantly reduced clinical and biochemical indices of myocardial reperfusion injury after elective coronary revascularization with cardiopulmonary bypass." Order ALL the reference details at left...
3.	Thrombolytic Therapy 01/01/1993 - "[Myocardial reperfusion injury with coronary thrombolytic therapy--clinical and experimental studies]" Order ALL the reference details at left...
4.	Heart Transplantation (Grafting, Heart) 08/01/2000 - "BACKGROUND: Neutrophils are major participants in myocardial reperfusion injury, but the relationship between ischemic time and the extent of the neutrophil sequestration in heart transplantation has not yet been systematically studied. " 10/01/2006 - "CONCLUSIONS: The use of leukocyte depleting filters in heart transplantation is an effective, easy and safe method of myocardial protection, reducing significant myocardial reperfusion injury and improving posttransplant graft functional recovery." 09/04/2002 - "BACKGROUND: Overactivation of the nuclear enzyme PARP importantly contributes to the development of cell dysfunction and tissue injury in various pathophysiologic conditions associated with oxidative stress, including myocardial reperfusion injury, heart transplantation, stroke, shock, and diabetes. " 02/01/2006 - "Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) contributes to the development of cell dysfunction and tissue injury in various pathophysiological conditions associated with oxidative and nitrosative stress, including myocardial reperfusion injury, heart transplantation, diabetic cardiomyopathy and chronic heart failure. " Order ALL the reference details at left...
5.	Angioplasty (Angioplasties) 05/18/2010 - "However, it does not provide an additional clinical benefit to placebo with respect to CIN and myocardial reperfusion injury in nonselected patients undergoing angioplasty with moderate doses of contrast medium and optimal hydration. " 10/01/1991 - "Demonstration of myocardial reperfusion injury in humans: results of a pilot study utilizing acute coronary angioplasty with perfluorochemical in anterior myocardial infarction." 05/01/2003 - "To evaluate the effects of synthetic human atrial natriuretic peptide (hANP) on myocardial reperfusion injury and left ventricular remodeling, 19 patients within 12 h of a first attack of anterior myocardial infarction (AMI) underwent intracoronary injection of 25 microg of hANP immediately after coronary angioplasty, combined with intravenous infusion of 0.025 microg x kg(-1) x min(-1) of hANP initiated on admission for 1 week (hANP group); 18 similar patients had saline administered (control group). " Order ALL the reference details at left...

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