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Hereditary Spastic Paraplegia

A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Also Known As:
Spastic Paraplegia, Hereditary; Autosomal Dominant Hereditary Spastic Paraplegia; Autosomal Dominant Spastic Paraplegia Hereditary; Autosomal Recessive Hereditary Spastic Paraplegia; Autosomal Recessive Spastic Paraplegia, Hereditary; CMT with Pyramidal Features; Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant; HMSN 5; HMSN Type V; HMSN V; HMSN V (Hereditary Motor and Sensory Neuropathy Type V); Hereditary Autosomal Dominant Spastic Paraplegia; Hereditary Autosomal Recessive Spastic Paraplegia; Hereditary Motor And Sensory Neuropathy V; Hereditary Motor and Sensory Neuropathy 5; Hereditary Motor-Sensory Neuropathy with Pyramidal Signs; Hereditary Spastic Paraplegia, Autosomal Recessive; Hereditary X-Linked Recessive Spastic Paraplegia; Hereditary, Spastic Paraplegia, Autosomal Dominant; Hereditary, Spastic Paraplegia, X-Linked Recessive; Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia; Paraplegia, Spastic, Hereditary; Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant; Spastic Paraplegia 2; Spastic Paraplegia Type 2; Spastic Paraplegia, Autosomal Dominant, Hereditary; Spastic Paraplegia, Autosomal Recessive, Hereditary; Spastic Paraplegia, Hereditary, Autosomal Dominant; Spastic Paraplegia, Hereditary, Autosomal Recessive; Spastic Paraplegia, Hereditary, X-Linked Recessive; Spastic Paraplegia, X-Linked Recessive, Hereditary; Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy; Type V Hereditary Motor and Sensory Neuropathy; X Linked Recessive Hereditary Spastic Paraplegia; X-linked Recessive Hereditary Spastic Paraplegia; Charcot Marie Tooth Disease with Pyramidal Features, Autosomal Dominant; Hereditary Motor Sensory Neuropathy with Pyramidal Signs; Hereditary Spastic Paraplegias; Hereditary X Linked Recessive Spastic Paraplegia; Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia; Paraplegia, Hereditary Spastic; Paraplegias, Hereditary Spastic; Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy; Spastic Paraplegias, Hereditary; Type V, HMSN; X-Linked, Spastic Paraplegia, Hereditary
Networked: 528 relevant articles (11 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pelizaeus-Merzbacher Disease
2. Nervous System Diseases (Neurological Disorders)
3. Paraplegia (Spastic Paraplegia)
4. Intellectual Disability (Idiocy)
5. Spinocerebellar Ataxias (Spinocerebellar Ataxia)

Experts

1. Blackstone, Craig: 22 articles (11/2022 - 12/2003)
2. Schöls, Ludger: 21 articles (04/2022 - 04/2008)
3. Schüle, Rebecca: 19 articles (04/2022 - 04/2008)
4. Stevanin, Giovanni: 17 articles (01/2022 - 04/2007)
5. Reid, Evan: 16 articles (07/2020 - 11/2002)
6. Rugarli, Elena I: 14 articles (01/2020 - 01/2002)
7. Brice, Alexis: 14 articles (01/2018 - 05/2002)
8. Durr, Alexandra: 13 articles (01/2021 - 04/2007)
9. Mochel, Fanny: 10 articles (10/2021 - 06/2009)
10. Züchner, Stephan: 10 articles (01/2019 - 08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hereditary Spastic Paraplegia:
1. BaclofenFDA LinkGeneric
2. Type A Botulinum Toxins (Botox)FDA Link
3. Biomarkers (Surrogate Marker)IBA
4. OxysterolsIBA
5. GangliosidesIBA
6. Botulinum Toxins (Botulinum Toxin)IBA
7. Messenger RNA (mRNA)IBA
8. Ursodeoxycholic Acid (Urso)FDA LinkGeneric
9. Mixed Function Oxygenases (Monooxygenases)IBA
10. Chenodeoxycholic Acid (Chenix)FDA Link

Therapies and Procedures

1. Therapeutics
2. Spinal Cord Stimulation
3. Transcranial Magnetic Stimulation
4. Ligation
5. Physical Therapy Modalities (Physical Therapy Technique)