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Histocompatibility Antigens Class I

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Also Known As:
Class I Histocompatibility Antigens; Class I Human Antigens; Class I MHC Proteins; Class I Major Histocompatibility Antigens; Class I Major Histocompatibility Molecules; Human Class I Antigens; MHC Class I Molecules; MHC-I Molecules; MHC-I Peptides; Antigen, Class I; Antigens, Class I; I Antigen, Class; MHC I Molecules; MHC I Peptide; MHC I Peptides; Molecules, MHC-I; Peptide, MHC-I; Peptides, MHC-I; Class I Antigen; Class I Antigens; Class I Histocompatibility Antigen; Class I MHC Protein; Class I Major Histocompatibility Antigen; MHC Class I Molecule; MHC-I Peptide
Networked: 1944 relevant articles (48 outcomes, 138 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ferrone, Soldano: 59 articles (01/2021 - 05/2003)
2. Seliger, Barbara: 27 articles (08/2020 - 05/2003)
3. Garrido, Federico: 20 articles (10/2021 - 03/2003)
4. Aptsiauri, Natalia: 10 articles (10/2021 - 07/2006)
5. Ruiz-Cabello, Francisco: 9 articles (10/2021 - 03/2003)
6. Seliger, B: 9 articles (11/2016 - 05/2000)
7. Yewdell, Jonathan W: 8 articles (12/2021 - 02/2007)
8. Kiessling, Rolf: 8 articles (11/2021 - 06/2002)
9. Carbone, Ennio: 8 articles (01/2021 - 01/2005)
10. Sabbatino, Francesco: 8 articles (01/2021 - 01/2013)

Related Diseases

1. Neoplasms (Cancer)
01/01/1991 - "Previous laboratory studies have suggested that natural immunity is a primordial defense mechanism against blood-borne metastatic cancer, its function being most effective against dedifferentiated, low-major-histocompatibility-complex-class-I-antigen-expressing tumors. "
01/09/2020 - "Likewise, PCI was pre-clinically shown to mediate major histocompatibility complex (MHC) class I antigen presentation and generation of tumor-specific cytotoxic CD8+ T-lymphocytes (CTL) and cancer remission. "
02/01/2006 - "Tumor cells that constitutively express MHC class I molecules and are genetically modified to express MHC class II (MHC II) and costimulatory molecules are immunogenic and have therapeutic efficacy against established primary and metastatic cancers in syngeneic mice and activate tumor-specific human CD4+ T lymphocytes. "
01/01/1988 - "A knowledge of the precise quantitative distribution of HLA class I antigens among various cell subpopulations of the normal human epidermis would be very useful for the study and follow-up of cutaneous malignancies that are known to lose these molecules as well as for the understanding of immune responses, especially allospecific, that involve the skin."
06/15/2007 - "In this mouse study, we compared monoclonal populations of tumor-specific CD4 and CD8 T cells as effectors against several different tumors, and found that CD4 T cells eliminated tumors that were resistant to CD8-mediated rejection, even in cases where the tumors expressed major histocompatibility complex (MHC) class I molecules but not MHC class II. MHC class II expression on host tissues was critical, suggesting that the CD4 T cells act indirectly. "
2. Infections
3. Melanoma (Melanoma, Malignant)
4. Polymyositis
5. Muscular Diseases (Myopathy)

Related Drugs and Biologics

1. Peptides (Polypeptides)
2. Antigens
3. Zidovudine (Retrovir)
4. Proteins (Proteins, Gene)
5. Electron Transport Complex IV (Cytochrome c Oxidase)
6. Vaccines
7. Histocompatibility Antigens Class II
8. Epitopes
9. Antibodies
10. Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)

Related Therapies and Procedures

1. Immunotherapy
2. Therapeutics
3. Radiotherapy
4. Transplantation
5. Aftercare (After-Treatment)