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Nimustine

Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
Also Known As:
NSC 245382; 245382, NSC; ACNU; Urea, N'-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-
Networked: 558 relevant articles (58 outcomes, 91 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kumabe, Toshihiro: 8 articles (04/2013 - 01/2002)
2. Tominaga, Teiji: 7 articles (04/2013 - 03/2007)
3. Kaina, Bernd: 6 articles (10/2015 - 12/2007)
4. Saito, Ryuta: 5 articles (04/2013 - 01/2002)
5. Watanabe, Mika: 4 articles (04/2013 - 11/2009)
6. Kochi, Masato: 4 articles (02/2013 - 02/2004)
7. Nakamura, Hideo: 4 articles (02/2013 - 06/2005)
8. Takano, Shingo: 4 articles (02/2013 - 01/2003)
9. Sonoda, Yukihiko: 4 articles (07/2012 - 11/2008)
10. Heo, Dae Seog: 4 articles (07/2011 - 11/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Glioma (Gliomas)
3. Brain Neoplasms (Brain Tumor)
4. Glioblastoma (Glioblastoma Multiforme)
5. Astrocytoma (Pilocytic Astrocytoma)

Related Drugs and Biologics

1. Nimustine
2. Vincristine (Oncovin)
3. Cisplatin (Platino)
4. Interferon-beta
5. Mannitol (Osmitrol)
6. ranimustine
7. Doxorubicin (Adriamycin)
8. Etoposide (VP 16)
9. Ifosfamide
10. temozolomide (Temodar)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Combination Drug Therapy (Combination Chemotherapy)
4. Adjuvant Chemotherapy
5. Intraperitoneal Injections