|1.||Kumabe, Toshihiro: 8 articles (04/2013 - 01/2002)|
|2.||Tominaga, Teiji: 7 articles (04/2013 - 03/2007)|
|3.||Kaina, Bernd: 6 articles (10/2015 - 12/2007)|
|4.||Saito, Ryuta: 5 articles (04/2013 - 01/2002)|
|5.||Watanabe, Mika: 4 articles (04/2013 - 11/2009)|
|6.||Kochi, Masato: 4 articles (02/2013 - 02/2004)|
|7.||Nakamura, Hideo: 4 articles (02/2013 - 06/2005)|
|8.||Takano, Shingo: 4 articles (02/2013 - 01/2003)|
|9.||Sonoda, Yukihiko: 4 articles (07/2012 - 11/2008)|
|10.||Heo, Dae Seog: 4 articles (07/2011 - 11/2002)|
01/01/2014 - "Our data suggest that the survival benefit of TMZ therapy is superior to that of an ACNU-based regimen in patients with extensive tumor resection, also shows greater tolerability. "
06/01/1981 - "These results suggest that ACNU is taken up by tumor tissue relatively rapidly and eliminated slowly, which leads to effective manifestation of its antitumor activity."
10/01/1996 - "Tumors showing a low MGMT activity responded well to ACNU and resulted in prolongation in the time to tumor progression. "
04/01/1993 - "This result suggests that some tumors, if determined to have low O6-MT activity, might be cured if the host is treated with ACNU. "
06/01/1991 - "The result suggests that some tumors, if provisionally determined with low O6-MT activity, might be efficiently cured by treatment with ACNU. "
05/01/2001 - "FLD treatment with ACNU is less effective against experimental glioma in rats than bolus treatment."
12/01/1992 - "ACNU [1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride], one of the chloroethylnitrosoureas (CENUs), is believed to be effective against malignant glioma when intravenously or intrathecally administered. "
03/01/1986 - "In order to analyze the efficacy of combination therapy with Hu-IFN-beta, ACNU and radiation (IAR), nine patients with malignant glioma were treated as a control study. "
08/01/1992 - "We applied conventionally fractionated irradiation combined with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), uneven fractionated irradiation with ACNU, low dose rate telecobalt therapy as a boost, and intraoperative irradiation against 110 malignant gliomas to investigate the efficacy of these methods as alternative treatments for malignant glioma. "
01/01/1987 - "In order to evaluate the efficacy of intrathecal therapy of MG with ACNU, MG models, which were produced by intracisternal inoculation of rat C6 glioma, were treated with intrathecal or intravenous administration of ACNU. "
|3.||Brain Neoplasms (Brain Tumor)
03/01/2007 - "Safety and efficacy of convection-enhanced delivery of ACNU, a hydrophilic nitrosourea, in intracranial brain tumor models."
01/01/1985 - "[Combination therapy with HU IFN-beta and ACNU against malignant brain tumors, Part 1. Experimental study in vitro]."
12/01/1983 - "Only a few studies have ever been reported concerning the pharmacokinetics of ACNU in human brain tumors. "
03/01/2007 - "CED of hydrophilic ACNU is a promising strategy for treating brain tumors."
08/19/1993 - "To improve therapeutic results of CENUs, we have measured MGMT activity of human brain tumors and studied the relationship between MGMT activity and clinical responsiveness to I-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU). "
|4.||Glioblastoma (Glioblastoma Multiforme)
01/01/2006 - "A randomized phase III study: comparison between intravenous and intraarterial ACNU administration in newly diagnosed primary glioblastomas."
08/01/2000 - "In conclusion, intra-arterial ACNU when administered by the method in this study does not increase the survival and progression-free survival of newly diagnosed patients with glioblastoma over that afforded by intravenous ACNU."
08/01/2000 - "This prospective randomized trial was performed to compare the effectiveness of intra-arterial ACNU with intravenous ACNU in newly diagnosed patients with supratentorial glioblastoma. "
05/01/2011 - "The authors report on a case of recurrent glioblastoma infiltrating the brainstem that regressed after CED of nimustine hydrochloride."
05/01/2011 - "Regression of recurrent glioblastoma infiltrating the brainstem after convection-enhanced delivery of nimustine hydrochloride."
|5.||Astrocytoma (Pilocytic Astrocytoma)
02/01/2013 - "This study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma (AA). "
03/01/2005 - "This study was undertaken to examine further the efficacy of the IAR regimen followed by maintenance therapy with IFN-beta and ACNU in patients with newly diagnosed malignant astrocytomas. "
08/01/1990 - "Group 2 consisted of five patients treated by operation, irradiation, and repeated intracarotid infusion of ACNU 100 mg/body alone (grade 4 astrocytoma). "
01/01/1990 - "15 patients with malignant astrocytomas were studied about correlation between the sensitivities of ACNU and post-operative clinical courses. "
10/01/1991 - "A 44-year-old female with malignant astrocytoma received subtotal removal and high dose (200 mg/m2) intra-arterial 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chloroethyl)-3-nitrosourea hydrochloride (ACNU) with autologous bone marrow transplantation. "
|8.||Etoposide (VP 16)
|1.||Drug Therapy (Chemotherapy)
|3.||Combination Drug Therapy (Combination Chemotherapy)