Biogenic Polyamines

Biogenic amines having more than one amine group. These are long-chain aliphatic compounds that contain multiple amino and/or imino groups. Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA.

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Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bartosch, Birke: 2 articles (12/2018 - 04/2018)
2.	Ivanov, Alexander V: 2 articles (12/2018 - 04/2018)
3.	Kochetkov, Sergey N: 2 articles (12/2018 - 04/2018)
4.	Araújo, Rita: 1 article (10/2021)
5.	Carneiro, Tatiana J: 1 article (10/2021)
6.	Diniz, Carmen: 1 article (10/2021)
7.	Gil, Ana M: 1 article (10/2021)
8.	Gonçalves-Monteiro, Salomé: 1 article (10/2021)
9.	Marques, Maria Paula M: 1 article (10/2021)
10.	Vojtek, Martin: 1 article (10/2021)

Related Diseases

1.	Neoplasms (Cancer) 12/18/2018 - "In particular, cancer cells exhibit elevated levels of biogenic polyamines. " 05/20/2004 - "Several polynuclear Pt(II) chelates with biogenic polyamines were synthesized and screened for their potential antiproliferative and cytotoxic activity in different human cancer cell lines. " 06/15/2006 - "Up-regulation of polyamine transporters on the surface of tumor cells and the internalization of biogenic polyamines by active transport processes may be exploited for the accumulation of spermidine derivatives as reporter molecules. "
2.	Breast Neoplasms (Breast Cancer) 06/14/2010 - "Biogenic polyamines are found to modulate protein synthesis at different levels, while polyamine analogues have shown major antitumor activity in multiple experimental models, including breast cancer. " 10/05/2021 - "In fact, palladium complexes with biogenic polyamines (e.g., spermine, Pd2Spm) have been known to display favorable antineoplastic properties against distinct human breast cancer cell lines. "
3.	Ganglion Cysts (Ganglion) 02/01/1988 - "In addition we have observed that the treatment of newborn rats with biogenic polyamines can prevent the naturally occurring reduction in the number of neurons in the ganglion. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/28/2004 - "The aggregation of alpha-synuclein, involved in the pathogenesis of several neurodegenerative disorders such as Parkinson's disease, is enhanced in vitro by biogenic polyamines binding to the highly charged C-terminal region aa109-140. "
5.	Virus Diseases (Viral Diseases) 04/17/2018 - "Here, we briefly summarize the current knowledge on the physiological roles of biogenic polyamines and the role of Ero1 at the ER, and present available data on their interplay with viral infections."

Related Drugs and Biologics

1.	Polyamines
2.	Carbon
3.	alpha-Synuclein
4.	Spermine
5.	Spermidine
6.	Proteins (Proteins, Gene)
7.	Palladium
8.	Antineoplastic Agents (Antineoplastics)
9.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Quantum Dots (Quantum Dot)