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Discitis

Inflammation of an intervertebral disk or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.
Also Known As:
Diskitis; Spondylodiskitis; Discitides; Diskitides; Spondylodiscitides; Spondylodiskitides; Spondylodiscitis
Networked: 493 relevant articles (34 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Abscess
2. Infection
3. Epidural Abscess
4. Osteomyelitis
5. Meningitis

Experts

1. Fu, Tsai-Sheng: 6 articles (03/2015 - 01/2010)
2. Chen, Wen-Jer: 5 articles (03/2015 - 01/2010)
3. Chen, Lih-Huei: 4 articles (03/2015 - 01/2010)
4. Tsai, Tsung-Ting: 3 articles (03/2015 - 01/2010)
5. Niu, Chi-Chien: 3 articles (03/2015 - 01/2011)
6. Boehm, Heinrich: 3 articles (02/2015 - 06/2009)
7. Gulow, Jens: 3 articles (01/2015 - 01/2013)
8. Kayser, Ralph: 3 articles (11/2014 - 10/2008)
9. Dai, Li-Yang: 3 articles (04/2014 - 10/2009)
10. Lai, Po-Liang: 3 articles (01/2014 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Discitis:
1. Anti-Bacterial Agents (Antibiotics)IBA
2. VancomycinFDA LinkGeneric
3. linezolid (Zyvox)FDA Link
4. Fluconazole (Zonal)FDA LinkGeneric
5. Cefazolin (Ancef)FDA LinkGeneric
6. C-Reactive ProteinIBA
7. Ofloxacin (Levofloxacin)FDA LinkGeneric
8. Rifampin (Rifampicin)FDA LinkGeneric
9. polylactic acid-polyglycolic acid copolymer (PLGA)IBA
10. Gentamicins (Gentamicin)FDA LinkGeneric

Therapies and Procedures

1. Debridement
2. Transplants (Transplant)
3. Drug Therapy (Chemotherapy)
4. Diskectomy (Discectomy)
5. Curettage