Neurokinin A

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.

Also Known As:

Neurokinin alpha; Neuromedin L; Substance K; Kassinin, 1-de-L-aspartic acid-2-de-L-valine-3-L-histidine-5-L-threonine-7-L-serine-

Networked: 269 relevant articles (3 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fischer, A: 5 articles (05/2011 - 03/2001)
2.	O'Dorisio, Thomas M: 3 articles (02/2021 - 10/2011)
3.	Mamikunian, Gregg: 3 articles (01/2018 - 10/2011)
4.	Woltering, Eugene A: 3 articles (01/2018 - 10/2011)
5.	Dinh, Q T: 3 articles (05/2011 - 06/2005)
6.	Sterk, Peter J: 3 articles (03/2007 - 05/2002)
7.	Kitamura, Hidemitsu: 2 articles (08/2022 - 02/2012)
8.	Erdemir, Ali: 2 articles (02/2021 - 10/2020)
9.	Howe, James R: 2 articles (02/2021 - 09/2014)
10.	Kisa, Ucler: 2 articles (02/2021 - 10/2020)

Related Diseases

1.	Asthma (Bronchial Asthma) 01/01/2008 - "The bronchoconstriction caused by inhaled neurokinin A (NKA) in patients with asthma is indirect. " 01/01/2004 - "Inhalation of neurokinin A (NKA) causes bronchoconstriction in patients with asthma. " 07/01/1995 - "Neurokinin A receptor antagonists have been proposed as a new class of drugs for several applications in humans (asthma, intestinal motility, etc.). " 01/01/2001 - "Airway hyperresponsiveness to neurokinin A (NKA) occurs in inflammatory airway diseases like asthma. " 03/01/2008 - "In comparison with the control group, children suffering from bronchial asthma showed statistically significant (p<0,001) increase of substance P and neurokinin A and decrease of VIP. "
2.	Virus Diseases (Viral Diseases) 04/15/2002 - "Viral infection (Day 4 after inoculation) was associated with a significantly greater number of labeled neurons containing Substance P/Neurokinin A (approximately 20% of total labeled neurons). "
3.	Inflammation (Inflammations) 01/01/2015 - "Reduced expression of neurokinin A in patients receiving PCT is associated with less activity and intensity of inflammation of esophageal mucosa. " 03/14/1997 - "These results indicate that endogenous neurokinin A increases the excitability of spinal neurons during persistent peripheral inflammation." 03/14/1997 - "The role of endogenous neurokinin A in changes in the excitability of spinal neurons during adjuvant-induced, peripheral inflammation was examined by determining the effect of a selective NK2 receptor antagonist, GR103537, on the nociceptive flexor reflex in rats. " 11/19/1990 - "The extensive spread and persistence of immunoreactive neurokinin A in the spinal cord may underlie some of the prolonged excitability changes evoked by brief noxious stimuli and peripheral inflammation reported by other laboratories." 04/15/2002 - "This induction appeared to be reversible as there were significantly fewer Substance P/Neurokinin A positive neurons in nodose ganglia from virus-inoculated guinea pigs at Day 28 after inoculation, a time point when virus-induced airway inflammation had all but resolved. "
4.	Allergic Rhinitis 01/01/1996 - "To study the density alterations of three peptidergic terminals in nasal mucosa of allergic rhinitis (AR), an exhaustive immunohistochemical sutdy on the changes of substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) in nasal mucosa was carried out in a toluene-2, 4-isocyanate (TDI)-induced rat AR model. " 01/01/2010 - "The objective of this study was to analyze the release of neuropeptides (substance P, neurokinin A, and vasoactive intestinal peptide) in nasal lavage and their modification by intranasal fluticasone propionate as an established therapy in patients with allergic rhinitis. " 11/01/1999 - "In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis. "
5.	Neurogenic Inflammation 06/01/2003 - "Neurokinin A (NKA) is an important sensory neuropeptide leading to neurogenic inflammation in airway. " 03/26/1998 - "Neurogenic inflammation, which results from peripheral release of substance P and neurokinin A, is almost absent in the mutant mice. " 07/02/1993 - "The differential roles of substance P and neurokinin A in spinal cord hyperexcitability and neurogenic inflammation." 06/01/1992 - "Neurokinin A, like substance P, may therefore have an important function in the transmission of sensory information, particularly in nociceptive transmission from the periphery to the spinal cord and in peripheral neurogenic inflammation. " 07/01/2017 - "Neurokinin A (NKA) and substance P (SP) are important neuropeptides in the dental pulp that can cause neurogenic inflammation. "

Related Drugs and Biologics

1.	Substance P
2.	Interleukin-8 (Interleukin 8)
3.	Calcitonin Gene-Related Peptide
4.	Neuropeptides
5.	Tachykinins
6.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
7.	Neuropeptide Y
8.	Neurokinin B
9.	Neurokinin-2 Receptors (Neurokinin 2 Receptor)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics
2.	Rectal Administration
3.	Ligation
4.	Intradermal Injections
5.	Slit Lamp