Neurokinin A

A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ B with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the BRONCHI.
Also Known As:
Neurokinin alpha; Neuromedin L; Substance K; Kassinin, 1-de-L-aspartic acid-2-de-L-valine-3-L-histidine-5-L-threonine-7-L-serine-
Networked: 225 relevant articles (2 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Fischer, A: 5 articles (05/2011 - 03/2001)
2. Dinh, Q T: 3 articles (05/2011 - 06/2005)
3. Sterk, Peter J: 3 articles (03/2007 - 05/2002)
4. Vinik, Aaron I: 2 articles (05/2015 - 10/2011)
5. O'Dorisio, Thomas M: 2 articles (09/2014 - 10/2011)
6. Mamikunian, Paris: 2 articles (12/2012 - 10/2011)
7. Woltering, Eugene A: 2 articles (12/2012 - 10/2011)
8. Mamikunian, Gregg: 2 articles (12/2012 - 10/2011)
9. Braun, A: 2 articles (05/2011 - 06/2005)
10. Gustavus, B: 2 articles (01/2011 - 01/2010)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Infection
3. Inflammation
4. Migraine Disorders (Migraine)
09/01/1989 - "It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception."
06/01/1997 - "In humans, vasodilation within the meningeal vasculature has been implicated in the pathogenesis of migraine, the present experiments indicate that substance P or neurokinin A (both acting through NK1 receptors) or CGRP may be responsible."
10/01/1995 - "We measured, by RIA methods, ictal and interictal levels of substance P (SP), calcitonin-gene related peptide (CGRP) and neurokinin A (NKA) in the plasma of 30 young migraine patients with aura (MPA) and 45 migraine patients without aura (MWA), and compared the results with those of 30 age-matched controls. "
02/19/1999 - "We have carried out an immunohistochemical study on the presence of neurokinin A (NKA) and substance P (SP) in the rat caudal trigeminal nucleus (CTN) after electrical stimulation of the trigeminal ganglion (TG), used as an experimental model to induce alterations, some of which may occur during migraine attacks (release of vasoactive peptides from perivascular trigeminal axons and neurogenic inflammation). "
03/01/2006 - "The present study was aimed at verifying the clinical characteristics of a typical attack in 20 migraine patients, 10 responders and 10 non-responders to rizatriptan, and at investigating any differences in the levels of neuropeptides of the trigeminovascular or parasympathetic systems [calcitonin gene-related peptide (CGRP), neurokinin A (NKA) and vasoactive intestinal peptide (VIP) measured by radioimmunoassay methods in external jugular blood] between responders and non-responders. "
5. Rhinitis

Related Drugs and Biologics

1. Substance P
2. Calcitonin Gene-Related Peptide
3. Neuropeptides
4. Tachykinins
5. Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
6. Neuropeptide Y
7. Neurokinin-2 Receptors (Neurokinin 2 Receptor)
8. Capsaicin (Zostrix)
9. Peptides
10. preprotachykinin

Related Therapies and Procedures

1. Rectal Administration
2. Intradermal Injections
3. Cystectomy
4. Radiotherapy
5. Moxibustion