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Merkel Cell Carcinoma

A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Also Known As:
Carcinoma, Merkel Cell; Merkel Cell Cancer; Merkle Tumors; Cancer, Merkel Cell; Cell Cancer, Merkel; Tumor, Merkel Cell; Tumors, Merkle; Merkel Cell Tumor
Networked: 476 relevant articles (24 outcomes, 43 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Neoplasm Metastasis (Metastasis)
3. Melanoma (Melanoma, Malignant)
4. Carcinoma (Carcinomatosis)
5. Extramammary Paget Disease (Paget Disease, Extramammary)

Experts

1. Schrama, David: 14 articles (03/2015 - 05/2006)
2. Koljonen, Virve: 13 articles (04/2015 - 01/2004)
3. Houben, Roland: 13 articles (03/2015 - 05/2006)
4. Böhling, Tom: 12 articles (04/2015 - 01/2004)
5. Becker, Jürgen C: 9 articles (04/2014 - 06/2009)
6. Nghiem, Paul: 9 articles (04/2014 - 07/2007)
7. Moore, Patrick S: 7 articles (04/2015 - 09/2009)
8. Chang, Yuan: 7 articles (04/2015 - 09/2009)
9. Haglund, Caj: 6 articles (04/2015 - 01/2004)
10. Sihto, Harri: 6 articles (12/2014 - 07/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Merkel Cell Carcinoma:
1. Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
2. Etoposide (VP 16)FDA LinkGeneric
3. Keratin-20 (Cytokeratin 20)IBA
4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
5. Octreotide (Sandostatin)FDA LinkGeneric
6. Carboplatin (JM8)FDA LinkGeneric
7. imatinib (Gleevec)FDA Link
8. Dermatofibrosarcoma protuberansIBA
9. Cisplatin (Platino)FDA LinkGeneric
10. Peptide Receptors (Peptide Receptor)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Aftercare (After-Treatment)
4. Adjuvant Radiotherapy
5. Mohs Surgery (Mohs' Micrographic Surgery)