HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Neprilysin (Neutral Endopeptidase)

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Also Known As:
Neutral Endopeptidase; Atriopeptidase; CD10 Antigen; Enkephalinase-24.11; Neutral Endopeptidase 24.11; Thermolysin-Like Metalloendopeptidase; YGG-Forming Enzyme; Antigen, CD10; Carboxypeptidase, Enkephalin Dipeptidyl; Dipeptidyl Carboxypeptidase, Enkephalin; Endopeptidase 24.11; Endopeptidase 24.11, Neutral; Endopeptidase, Neutral; Enkephalinase 24.11; Enzyme, YGG-Forming; Kidney Brush Border Neutral Proteinase; Membrane Metallo Endopeptidase; Metallo-Endopeptidase, Membrane; Metalloendopeptidase, Thermolysin-Like; Neutral Proteinase, Kidney-Brush-Border; Thermolysin Like Metalloendopeptidase; YGG Forming Enzyme; Antigens, CD10; Antigens, Leukemia, Common Acute Lymphoblastic; CALLA Antigen; CD10 Antigens; Common Acute Lymphoblastic Leukemia Antigens; Endopeptidase-24.11; Enkephalin Dipeptidyl Carboxypeptidase; Enkephalinase; Kidney-Brush-Border Neutral Proteinase; Membrane Metallo-Endopeptidase
Networked: 1845 relevant articles (134 outcomes, 274 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. McMurray, John J V: 62 articles (01/2022 - 10/2012)
2. Solomon, Scott D: 55 articles (01/2022 - 10/2012)
3. Packer, Milton: 51 articles (01/2022 - 08/2002)
4. Zile, Michael R: 33 articles (12/2021 - 09/2013)
5. Desai, Akshay S: 28 articles (12/2021 - 09/2013)
6. Rouleau, Jean L: 27 articles (01/2022 - 09/2002)
7. Swedberg, Karl: 27 articles (01/2022 - 08/2002)
8. Lefkowitz, Martin P: 22 articles (01/2022 - 09/2013)
9. Jhund, Pardeep S: 21 articles (01/2022 - 06/2014)
10. Shi, Victor: 19 articles (01/2022 - 10/2012)

Related Diseases

1. Heart Failure
2. Hypertension (High Blood Pressure)
3. Type 2 Diabetes Mellitus (MODY)
4. Alzheimer Disease (Alzheimer's Disease)
5. Systolic Heart Failure

Related Drugs and Biologics

1. Angiotensin Receptors (Angiotensin II Receptor)
2. sacubitril and valsartan sodium hydrate drug combination
3. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
4. Angiotensin Receptor Antagonists
5. Enalapril
6. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
7. Valsartan (Vals)
8. Sodium
9. Glucose (Dextrose)
10. Neprilysin (Neutral Endopeptidase)

Related Therapies and Procedures

1. Therapeutics
2. Percutaneous Coronary Intervention
3. Drug Therapy (Chemotherapy)
4. Heart-Assist Devices
5. Cardiac Resynchronization Therapy