Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 22.214.171.124 and EC 126.96.36.199 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 188.8.131.52.
Also Known As:
Deoxyribonucleases, Type I Site-Specific; DNase, Site Specific, Type I; Deoxyribonucleases, Type I, Site Specific; Deoxyribonucleases, Type I, Site-Specific; Site-Specific DNase, Type I; Type I Site Specific DNase; Type I Site Specific Deoxyribonucleases; Type I Site-Specific DNase; Deoxyribonucleases, Type I Site Specific; Site Specific DNase, Type I; DNA Restriction Enzymes, Type I; DNase, Site-Specific, Type I; Restriction Endonucleases, Type I; Type I Restriction Enzymes