Ofloxacin (Levofloxacin)

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2206 relevant articles (382 outcomes, 437 trials/studies) found for this Drug

Description: A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

Also Known As:

Levofloxacin; Levaquin; Ofloxacine; Quixin; DL-8280; DR-3355; Hoe-280; ORF-28489; Ofloxacin Hydrochloride; Ofloxacin, (S)-Isomer; Ru-43280; Tarivid; DL 8280; DL8280; DR 3355; DR3355; Hoe 280; Hoe280; ORF 28489; ORF28489; Ru 43280; Ru43280; (+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 23

2-Ring Heterocyclic Compounds

Quinolines: 58

Quinolones: 969

Fluoroquinolones: 1268

Ofloxacin: 2206

desmethylofloxacin: 2

ofloxacin N-oxide: 2

antofloxacin: 1

3-fluoromethyl ofloxacin

ofloxacin O-glucuronide

ofloxacin pivaloyloxymethyl ester

R 71762

Experts

1.	Kahn, James B: 12 articles (01/2008 - 08/2002)
2.	Tennenberg, Alan M: 10 articles (12/2006 - 09/2003)
3.	Khashab, Mohammed M: 7 articles (12/2006 - 09/2003)
4.	Zadeikis, Neringa: 7 articles (08/2005 - 09/2003)
5.	Xiang, Jim X: 5 articles (12/2006 - 09/2003)
6.	Wu, Shu-Chen: 5 articles (05/2006 - 02/2003)
7.	Naber, K G: 4 articles (08/2008 - 05/2000)
8.	Arguedas, Adriano: 4 articles (06/2008 - 07/2005)
9.	Drusano, George L: 4 articles (05/2008 - 11/2006)
10.	Chan, C K: 4 articles (10/2007 - 03/2000)

Related Diseases

1.	Infection 02/01/1987 - "Ofloxacin proved to be extremely effective in curing experimental infections induced by both gram-positive and gram-negative pathogens." 01/01/1986 - "On the basis of these preliminary results, ofloxacin can be considered as a highly efficient oral substance which is effective against Staphylococcus aureus and Pseudomonas aeruginosa, two important pathogens in inflammatory ear infections." 08/15/2002 - "This study tested whether levofloxacin, at a new high dose of 750 mg, was effective for the treatment of complicated skin and skin-structure infections (SSSIs)" 01/01/2004 - "High-dose levofloxacin is able to exploit these pharmacokinetic features to provide an effective treatment for severe infections" 11/01/1991 - "Two patients who developed post-operative sternotomy infections due to Nocardia asteroides were treated successfully with ofloxacin, in vitro susceptibility of the organisms being used as a guide to dosage" Get all the results and reference details, order at left...
2.	Pneumonia (Pneumonitis) 01/01/1992 - "Intravenous followed by oral ofloxacin was highly effective in many difficult cases of pneumonia." 09/01/2002 - "We conclude that levofloxacin is effective against experimental pneumonia due to pneumococci with MIC < 1.5 mg/L, ineffective on experimental pneumonia due to pneumococci with MIC > or = 2 mg/L, and could be associated with the appearance of mutants when a parC mutation is pre-existing." 07/01/1998 - "In experimental pneumonia in guinea pigs, in which the biofilm mode of growth of the strain was observed in the lung, only levofloxacin exhibited substantial therapeutic efficacy" 05/01/1996 - "When given as monotherapy for the empiric treatment of community-acquired pneumonia, ofloxacin is as effective as standard antimicrobial therapy." 01/01/1992 - "Conversely, ofloxacin was equally effective in cases in whom previous therapy failed and in cases of nosocomial pneumonia, multilobar pneumonia, and/or pneumonia due to S" Get all the results and reference details, order at left...
3.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1996 - "In the treatment of patients with noncomplicated urinary tract infection good results (the clinical and bacteriological efficacies of 96 and 88 per cent respectively) were observed when ofloxacin was used orally in a single dose of not more than 400 mg once a day for 3 to 5 days" 03/01/2003 - "CONCLUSION: These study results indicate that levofloxacin 250 mg orally once daily for 10 days is an effective and well tolerated treatment of complicated urinary tract infections." 08/01/1987 - "This study showed that Ofloxacin is effective against urinary tract infections." 01/01/1988 - "The clinical efficacy of the new quinolone antibacterial agent ofloxacin (OFLX) on urinary tract infections (UTI) was reevaluated" 01/01/1993 - "The efficacy of single dose ofloxacin in lower urinary tract infections was investigated in this study" Get all the results and reference details, order at left...
4.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/1991 - "Ofloxacin is a proven antibiotic substance useful in the treatment of lower respiratory tract infections." 07/20/2005 - "500 mg once daily of levofloxacin was expected to be effective for the treatment of respiratory tract infections caused by S" 01/01/1987 - "In 535 cases with lower respiratory infections, ofloxacin was effective in 78.1%" 06/01/1999 - "These in-vitro results suggest that levofloxacin may be useful in the treatment of community-acquired lower respiratory tract infections." 01/01/1992 - "Our data indicate that ofloxacin is effective and safe as specific and empiric treatment for many lower respiratory tract infections." Get all the results and reference details, order at left...
5.	Typhoid Fever (Typhoid) 04/01/1995 - "A 3-day course of ofloxacin proved to be safe and highly effective in the treatment of uncomplicated, multidrug-resistant typhoid fever." 09/01/1994 - "Ofloxacin was found to be well tolerated and effective in treating typhoid fever." 01/01/1990 - "Ofloxacin was well tolerated and appears to be an effective agent in the treatment of typhoid fever." 01/01/1988 - "Ofloxacin was particularly effective in the treatment of enteric fever in 35 patients; eradication was achieved in all of them; 34 patients were clinically cured within 4 days, however, one patient with bacteraemia due to Salmonella paratyphi A subsequently died, due to his underlying disorder" 01/01/1986 - "Ofloxacin was also effective in the treatment of enteric fever, in which eradication was achieved in all seven patients" Get all the results and reference details, order at left...
399 Diseases and 2206 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Ofloxacin (Levofloxacin)
3.	Rifampin (Rifampicin)
4.	Norfloxacin
5.	Vancomycin
6.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
7.	Azithromycin (Zithromax)
8.	Clarithromycin (Biaxin)
9.	Doxycycline (Vibramycin)
10.	Pefloxacin
462 Drugs and Important Bio-Agents and 1328 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Middle Ear Ventilation (Tympanostomy)
3.	Transplants (Transplant)
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
5.	Artificial Respiration (Mechanical Ventilation)
57 Therapies and Procedures and 151 more articles analyzed in the Research Interface, order at left...

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