|1.||Ballantyne, Christie M: 16 articles (05/2015 - 08/2002)|
|2.||Davidson, Michael H: 16 articles (01/2015 - 01/2003)|
|3.||Havekes, Louis M: 16 articles (08/2013 - 09/2002)|
|4.||Rensen, Patrick C N: 14 articles (11/2015 - 07/2004)|
|5.||Adeli, Khosrow: 13 articles (09/2015 - 03/2002)|
|6.||Hegele, Robert A: 13 articles (01/2015 - 01/2002)|
|7.||Maki, Kevin C: 13 articles (01/2015 - 11/2005)|
|8.||Vaziri, Nosratola D: 13 articles (04/2014 - 01/2002)|
|9.||Watts, Gerald F: 12 articles (12/2015 - 03/2006)|
|10.||Kypreos, Kyriakos E: 12 articles (02/2013 - 02/2003)|
08/01/2011 - "Hypertriglyceridemia is characterized by increased production and decreased clearance of triglyceride-rich lipoproteins including very low-density lipoprotein (VLDL) and chylomicron. "
08/01/2009 - "Hypertriglyceridemia is a consequence of increased VLDL synthesis from the liver, which is also loaded by ectopic triglyceride deposition, reduced clearance of triglyceride-rich lipoproteins or both. "
03/01/2009 - "ApoCIII causes hypertriglyceridemia by inhibiting the catabolism and the clearance of TG-rich lipoproteins (TLRs), and the association of apoCIII with CHD has been commonly attributed to these properties; however, it has been untested whether apoCIII itself or in association with lipoproteins directly affects atherogenic mechanisms in vascular cells. "
05/01/1991 - "One reason for the variability of results obtained with H-1 NMR may be that hypertriglyceridemia also induces linewidth narrowing of lipoprotein lipid methyl and methylene resonances, and can cause false positive results. "
08/27/1984 - "Finally, hepatic overproduction of VLDL can produce hypertriglyceridemia, or if there is a concomitant defect in clearance of lipoproteins, an accentuated increase of VLDL, remnants or LDL will occur. "
|2.||Insulin (Novolin)FDA Link
11/01/2014 - "Thus, combination of intravenous insulin with fasting appears to be an effective, simple, and safe treatment strategy in immediate management of extreme hypertriglyceridemia."
05/01/2006 - "Insulin therapy for diabetic and non-diabetic patients with severe hypertriglyceridemia is an effective and safe treatment."
08/01/1995 - "In the fourth patient, insulin requirements and fasting hypertriglyceridemia decreased without improvement in glycemic control. "
01/01/1992 - "Physical activity has been shown to improve insulin sensitivity, reduce hypertriglyceridemia, improve fibrinolytic capacity, and reduce the blood pressure. "
09/01/2011 - "This double-blind, randomized, controlled crossover trial in 19 men and women with hypertriglyceridemia (fasting TG ≥150 and ≤499mg/dL) examined lipid responses and indices of insulin sensitivity and secretion following a liquid meal tolerance test. "
07/01/1995 - "The marked VLDL hypertriglyceridemia was decreased by 70% (P < .001), with an accompanying significant reduction in cholesterol concentrations. "
04/01/1978 - "Nineteen (26%) of these male patients had serum triglyceride levels greater than 150 mg/100 ml and six (9%) had serum cholesterol levels greater than 250 mg/100 ml. Compared to 33 age-matched, nonalcoholic control subjects, there was a significantly greater incidence of hypertriglyceridemia in the alcoholic subjects. "
10/01/2014 - "Clinical guidelines recommend the use of calculated LDL-C to guide therapy because the evidence base for cholesterol management is derived almost exclusively from trials that use calculated LDL, with direct measurement of LDL-C being reserved for those patients who are non fasting or with significant hypertriglyceridemia. "
01/01/2011 - "However, many recent studies have suggested that rats do not develop hypertriglyceridemia in response to cholesterol feeding. "
07/01/2010 - "Clinical guidelines recommend the use of calculated LDL-C (C-LDL-C) to guide therapy because the evidence base for cholesterol management is derived almost exclusively from trials that use C-LDL-C, with direct measurement of LDL-C (D-LDL-C) being reserved for those patients who are nonfasting or with significant hypertriglyceridemia. "
02/01/2011 - "The higher dose (3.4 g/d) of EPA+DHA significantly lowered triglycerides, but neither dose improved endothelial function or inflammatory status over 8 wk in healthy adults with moderate hypertriglyceridemia. "
10/01/1981 - "It is concluded that UDCA does not affect serum lipid levels, whereas CDCA lowers serum triglycerides and may be useful in the treatment of endogenous hypertriglyceridemia."
10/01/2007 - "The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides."
11/01/2014 - "Data from basic and clinical studies indicate that hypertriglyceridemia plays an important role in the pathogenesis of vascular complications, but the role of triglycerides (TG) in the normal range remains unresolved in T1D. "
08/01/2014 - "Forty-one HIV-seropositive subjects with hypertriglyceridemia (≥150 mg/dl) on active antiretroviral therapy were enrolled in this placebo-controlled, double-blind, randomized, crossover trial comparing the effects of omega-3 fatty acid treatment (1.9 g EPA and 1.5 g DHA) on triglycerides, LDL-C, HDL-C, and HDL subpopulations. "
04/01/1995 - "Our study indicates that the compound is potentially beneficial for the treatment of hypertriglyceridemia with low HDL cholesterol in diabetes."
03/01/2012 - "Compared to studies performed at similar locations in years 2002-03 and 2005-06 there was increasing trend in prevalence of high non-HDL cholesterol and hypertriglyceridemia (Ptrend < 0.05) while other risk factors did not change significantly. "
09/01/2007 - "Sustained hypertriglyceridemia and low high-density lipoprotein-cholesterol during the study period was significantly associated with the genetic score. "
04/01/1995 - "The aim of this study was to ascertain whether the compound has the same action in diabetes, because hypertriglyceridemia with low HDL cholesterol is an extremely common concomitant condition in diabetes. "
10/01/1992 - "Therefore, hypertriglyceridemia and hypo-HDL-emia may be the result of the same primary abnormality; as the HDL-cholesterol level is more stable, it is the parameter which will be identified as a protective factor in epidemiological trials. "
06/01/2011 - "Globularia alypum aqueous extract decreases hypertriglyceridemia and ameliorates oxidative status of the muscle, kidney, and heart in rats fed a high-fructose diet."
01/01/2015 - "In the present study, a high-fructose diet (HFrD) fed rat model of hypertriglyceridemia was employed to further delineate the underlying mechanism by which NDGA exerts its anti-hypertriglyceridemic action. "
01/01/2013 - "In the study of hypertriglyceridemia induced by fructose, AEBO in doses of 400 mg/kg and 800 mg/kg reduced TG levels by 48.2% and 48.7%, respectively. "
01/01/2011 - "These studies provide novel insight into the mechanisms involved in fructose-mediated hepatic hypertriglyceridemia and identify fructose-uptake as a new potential therapeutic target for lipid-associated diseases."
09/01/2009 - "This study evaluated the effects that different doses of MATK-90 had on lipid levels and clinical parameters in male Wistar rats fed a high-fructose diet used to induce hypertriglyceridemia (TAG > or = 300 mg/dL). "
|7.||Lipoprotein Lipase (Diacylglycerol Lipase)IBA
01/01/2007 - "Differential diagnosis of hypertriglyceridemia and medical practice involved in their prevention and treatment may be improved by knowing the frequency of lipoprotein lipase gene variants as well as their influence on lipid profile."
01/01/2006 - "We conclude that RTV causes hypertriglyceridemia via decreased lipoprotein lipase-mediated clearance of VLDL-TG. "
01/01/1992 - "Patients with diabetes commonly manifest hypertriglyceridemia along with decreased adipose tissue lipoprotein lipase (LPL) activity, and improved diabetes control tends to reverse these abnormalities. "
01/01/1993 - "Previous studies have demonstrated that endotoxin/lipopolysaccharide treatment causes a decrease in adipose tissue and heart lipoprotein lipase (LPL) activities in rats, producing hypertriglyceridemia in these animals. "
02/01/1988 - "Six patients with severe hypertriglyceridemia (2 type IV and 4 type V) and low lipoprotein lipase (LPL) activity took part in a second, open study, lasting for 9 months. "
|8.||Glucose (Dextrose)FDA LinkGeneric
05/01/2010 - "Using the 75th percentile value as a cut point, those with isolated large visceral AT showed significantly greater odds ratios for each of the 5 risk factors measured except impaired fasting glucose, whereas those with isolated high HOMA-IR showed significantly greater odds ratios for each of the 5 risk factors except hypertriglyceridemia and impaired glucose tolerance, compared with the control group. "
06/01/1992 - "Hypertriglyceridemia is usually due to poorly controlled diabetes and responds to improved glucose control. "
04/01/2015 - "In this study, we sought to compare the impact of maternally and paternally inherited hypertriglyceridemia on glucose and lipid metabolism in mice. "
01/01/2014 - "Dietary Intake, Changes in Lipid Parameters and the Risk of Hypertriglyceridemia: A Prospective Approach in the Tehran Lipid and Glucose Study."
07/25/2008 - "Since diabetes is often associated with hypertriglyceridemia, this study explores whether APOA5 gene expression is regulated by alteration in glucose homeostasis and the related pathways. "
06/24/2008 - "The increase in CETP activity and suppression in LPL activity following CsA and RAPA treatment observed in the present study may be associated with elevated LDL cholesterol levels and hypertriglyceridemia seen in patients administered these drugs."
01/01/2001 - "The triglyceride lowering effect and the elevation in LDL cholesterol were most marked in those trials that recruited people with hypertriglyceridemia and used higher doses of fish oil. "
06/01/1997 - "The purpose of this study was to evaluate the LipiDirect assay (L-LDL) against the Direct LDL immunoseparation method (D-LDL) and beta quantification (BQ-LDL) for measurement of LDL cholesterol (LDL-C) in patients with normo- and hypertriglyceridemia. "
11/01/2015 - "Hypertriglyceridemia is a major factor associated with elevated levels of small dense LDL cholesterol in patients with metabolic syndrome."
01/01/2014 - "In 3 years numbers of patients with hypertriglyceridemia and elevated low density lipoprotein cholesterol significantly decreased. "
|10.||Fenofibrate (CiL)FDA LinkGeneric
05/01/1998 - "It is also effective in patients with isolated hypertriglyceridemia and, although less potent than fenofibrate at reducing TRL and increasing HDL-C, it has a greater impact on the atherogenic risk ratios such as LDL-C:HDL-C. "
06/01/2004 - "Fenofibrate is an effective, well-tolerated treatment for hypertriglyceridemia associated with HLS."
06/01/2005 - "The aim of this study was to assess the food-related efficacy of a new formulation of micronized fenofibrate coated on inert microgranules (FF-muG) for the treatment of hypertriglyceridemia in patients exhibiting the metabolic syndrome. "
08/01/2007 - "Fenofibrate therapy ameliorates fasting and postprandial lipoproteinemia, oxidative stress, and the inflammatory response in subjects with hypertriglyceridemia and the metabolic syndrome."
03/01/2006 - "In the present study, 45 subjects with hypertriglyceridemia were recruited to receive treatment with fenofibrate (200 mg/d). "
07/27/2014 - "[Plasmapheresis in the treatment of hypertriglyceridemia]."
11/01/2013 - "Severe hypertriglyceridemia in a 6-year-old boy with ALL relapse: successfully treated with plasmapheresis."
08/01/2013 - "Plasmapheresis in the management of severe hypertriglyceridemia."
01/01/2012 - "Plasmapheresis is an underevaluated modality of the treatment of hypertriglyceridemia due to its cost and availability."
01/01/2012 - "Use of plasmapheresis in managing the diagnostic dilemma of symptomatic hypertriglyceridemia."
01/01/2002 - "We report dramatic improvement in clinical and laboratory parameters after intensive plasma exchange therapy in a 15-yr-old girl with acquired generalized lipoatrophy and refractory hypertriglyceridemia. "
06/01/2006 - "Plasma exchange in severe hypertriglyceridemia a clinical study."
09/01/2013 - "[Treatment of hypertriglyceridemia: plasma exchange]."
12/01/2009 - "Therapeutic plasma exchange in patients with severe hypertriglyceridemia: a multicenter study."
01/01/2009 - "Long-term plasma exchange for severe refractory hypertriglyceridemia: a decade of experience demonstrates safety and efficacy."
|3.||Drug Therapy (Chemotherapy)
11/01/2000 - "These data and observations from patients in the Helsinki Heart Study and the Stockholm Ischemic Heart study, that the greatest coronary benefit during lipid-lowering drug therapy occurred among hypertriglyceridemic patients, argue strongly for an independent role for hypertriglyceridemia in CHD risk. "
10/01/2014 - "Recent advances in pharmacotherapy for hypertriglyceridemia."
05/01/2014 - "His diabetes and hypertriglyceridemia were newly diagnosed and drug therapy was instituted with home discharge on day 14. "
07/01/2011 - "Treatment for severe hypertriglyceridemia is often 3-fold, including lifestyle changes, diet modification, and pharmacotherapy. "
09/01/2005 - "Patients with measurable disease, no more than one previous chemotherapy regimen for metastatic disease, and normal organ function were eligible, and patients with central nervous system involvement, P450-inducing or P450-suppressing drugs, or hypertriglyceridemia were excluded. "
|4.||Fat-Restricted Diet (Diet, Fat Restricted)
11/01/2012 - "These findings offer a potential therapeutic advantage of the OM-3 FFA formulation for the treatment of severe hypertriglyceridemia as these patients are expected to adhere to a low-fat diet."
06/01/2004 - "Individual serum triglyceride responses to high-fat and low-fat diets differ in men with modest and severe hypertriglyceridemia."
01/01/1981 - "A severely fat-restricted diet controlled the hypertriglyceridemia in 1 of the patients, followed during a second pregnancy."
04/01/1976 - "Induction of hypertriglyceridemia by a low-fat diet."
12/01/2009 - "In order to evaluate the therapeutic efficacy of plasma-exchange plasmapheresis in treating patients with severe hypertriglyceridemia (sHTG), 17 patients who had not responded to conventional medical therapy (fat-free diet plus pharmaceutical interventions) were referred for therapeutic plasma exchange (TPE) in a multicenter frame case series study. "
|5.||Continuous Ambulatory Peritoneal Dialysis (CAPD)
07/01/1981 - "Increasing hypertriglyceridemia is a recognised complication of CAPD. "
07/01/1981 - "Accelerated hypertriglyceridemia in patients on continuous ambulatory peritoneal dialysis - a preventable abnormality."
05/01/2001 - "These results indicate that insulin resistance is an important factor in the development of hypertriglyceridemia in CAPD patients."
05/01/2001 - "Association of hypertriglyceridemia and insulin resistance in uremic patients undergoing CAPD."
01/01/1993 - "Lipid abnormalities, both hypercholesterolemia and particularly hypertriglyceridemia (hyperTg), are common in long-term continuous ambulatory peritoneal dialysis (CAPD) patients. "