Hypertriglyceridemia

06/01/1980 - "One, where there was a low K2, suggesting that defective clearance of triglyceride was the major etiological factor in the hypertriglyceridemia and two, those patients with a normal K2 value, where other factors appear to be more important."
02/01/2011 - "The higher dose (3.4 g/d) of EPA+DHA significantly lowered triglycerides, but neither dose improved endothelial function or inflammatory status over 8 wk in healthy adults with moderate hypertriglyceridemia. "
01/01/1996 - "Kinetic analyses of triglyceride synthesis carried out in rats on a standard diet revealed, in exposed animals, a significant reduction in the secretory rate, in spite of the concomitant hypertriglyceridemia. "
12/17/2020 - "The results indicated that RN administration resulted in an improvement in the overall lipid metabolism and a decrease in the concentration of triglycerides in the HFC diet-induced rat model of hypertriglyceridemia. "
10/01/2019 - "Results of ongoing studies may show the benefit of lowering triglycerides and provide new standards of care for patients with hypertriglyceridemia possibly through improvement in endothelial function."

01/01/2022 - "As TGs are carried by lipoproteins in plasma, hypertriglyceridemia can result from overproduction or lack of clearance of TG-rich lipoproteins (TRLs) such as VLDLs. "
03/01/2009 - "ApoCIII causes hypertriglyceridemia by inhibiting the catabolism and the clearance of TG-rich lipoproteins (TLRs), and the association of apoCIII with CHD has been commonly attributed to these properties; however, it has been untested whether apoCIII itself or in association with lipoproteins directly affects atherogenic mechanisms in vascular cells. "
01/01/2012 - "Although ApoCIII transgenic mice have been generated as an animal model for the study of hypertriglyceridemia, the features of lipoprotein metabolism in mice differ greatly from those in humans. "
01/01/2006 - "The present study indicates that CRF patients have disturbed lipoprotein composition, and that hypertriglyceridemia and low HDL-C concentrations in these patients are multifactorial, being secondary to disturbed lipoproteins. "
04/01/2003 - "Charge-based heterogeneity of human plasma lipoproteins at hypertriglyceridemia: capillary isotachophoresis study."

05/01/2023 - "In patients with hypertriglyceridemia, a short-term low-saturated fat vs high-saturated fat diet induced lower plasma lipids and improved monocyte phenotypes. "
12/01/2003 - "Nevertheless, relatively fast plasma clearance of lipids infused indicates that a reduction in lipid supply could be a quick, effective measure for controlling hypertriglyceridemia. "
12/01/2011 - "The discrimination of adult hypertriglyceridemia improved when GRS was added to childhood lipid measurement (C statistic=0.04, P=0.01). "
11/01/2018 - "Rapid lipid infusion induced hypertriglyceridemia without other apparent risks in this study. "
09/05/2018 - "This study evaluated and compared the risk profiles of patients with hypertriglyceridemia, low-HDL-C levels or AD, in order to understand, which lipid profile is associated with greater risk. "

11/01/2023 - "The main objective of this study was to evaluate the safety and efficacy of a continuous intravenous insulin infusion order set specifically designed for managing hypertriglyceridemia. "
12/01/2018 - "Insulin is an unusual and affordable therapeutic option for some patients with severe hypertriglyceridemia and can be helpful in the prevention of acute and chronic complications. "
11/01/2014 - "Thus, combination of intravenous insulin with fasting appears to be an effective, simple, and safe treatment strategy in immediate management of extreme hypertriglyceridemia."
07/26/2019 - " Intravenous insulin is a safe and effective acute treatment for hypertriglyceridemia in children, even in infants. "
01/01/2022 - "To evaluate the safety and efficacy of IV insulin infusions in the acute management of hypertriglyceridemia. "

07/01/1995 - "The marked VLDL hypertriglyceridemia was decreased by 70% (P < .001), with an accompanying significant reduction in cholesterol concentrations. "
01/01/2020 - "Exacerbated postprandial hypertriglyceridemia (PP-HTG) and metabolic context both modulate the overall efficacy of the reverse cholesterol transport (RCT) pathway, but the specific contribution of exaggerated PP-HTG on RCT efficacy remains indeterminate. "
01/01/2016 - "Through this mechanism, KLF15 overexpression specifically ameliorates hypertriglyceridemia without affecting LXR-mediated cholesterol metabolism. "
12/17/2020 - "The present study was designed to investigate the inhibitory effect of roasted Nelumbinis folium (RN), which is a medicinal substance produced by heating lotus leaves, on lipid metabolism in high fat/cholesterol (HFC) diet-induced hypertriglyceridemia. "
01/01/2019 - "spinosa oxymel had no significant effect on the serum cholesterol but inhibited the progression of hypertriglyceridemia during the study. "

04/01/1995 - "Our study indicates that the compound is potentially beneficial for the treatment of hypertriglyceridemia with low HDL cholesterol in diabetes."
01/01/2017 - "Low levels of HDL cholesterol and hypertriglyceridemia are more prevalent in our study population. "
02/01/2016 - "The high prevalence of low HDL cholesterol and hypertriglyceridemia, especially in Brazil's North and Northeast regions, must be analyzed in future studies, to support the creation of strategies for efficient interventions. "
03/01/2012 - "Compared to studies performed at similar locations in years 2002-03 and 2005-06 there was increasing trend in prevalence of high non-HDL cholesterol and hypertriglyceridemia (Ptrend < 0.05) while other risk factors did not change significantly. "
09/01/2007 - "Sustained hypertriglyceridemia and low high-density lipoprotein-cholesterol during the study period was significantly associated with the genetic score. "

09/01/2008 - "In particular, hypertriglyceridemia and the ratio of small dense:large buoyant LDL particles are significantly improved. "
07/01/2012 - "The aim of this study was to investigate the association between leukocyte subtype counts and hyper-LDL cholesterolemia, hypertriglyceridemia, and hypo-HDL cholesterolemia. "
01/01/2006 - "Dyslipemia was manifested by increased concentration of tChol in 22%, elevated values of LDL Chol in 26%, decreased concentration of HDL Chol in 50%, and hypertriglyceridemia in 46% of study subjects. "
12/01/2004 - "The purpose of the present study was to investigate whether hypertriglyceridemia-induced small LDL particles are associated with endothelial dysfunction in postmenopausal women. "
11/01/2003 - "In the present study, we evaluated the impact of postprandial hypertriglyceridemia on the variation in LDL particle size. "

06/01/1992 - "Hypertriglyceridemia is usually due to poorly controlled diabetes and responds to improved glucose control. "
04/01/2015 - "In this study, we sought to compare the impact of maternally and paternally inherited hypertriglyceridemia on glucose and lipid metabolism in mice. "
07/25/2008 - "Since diabetes is often associated with hypertriglyceridemia, this study explores whether APOA5 gene expression is regulated by alteration in glucose homeostasis and the related pathways. "
12/01/2023 - "POI women presented with more unfavorable cardiovascular risk factors (higher prevalence of hypertriglyceridemia and high fasting glucose; higher TG, FINS, and HOMA-IR). "
12/01/2023 - "The prevalence of hypertriglyceridemia and high fasting glucose was significantly higher in POI than control (17.8% vs. 9.3%, p = .039; 16.9% vs. 6.6%, p = .008), without significant differences in the prevalence of other components of MetS (p > .05). "

08/01/2018 - "Results showed that only fructose-supplemented rats displayed postprandial and fasting hypertriglyceridemia (1.4 and 1.9-fold, p < 0.05) and a significant reduction in the discrimination index in the NOR test, whereas the results of the MWM test showed no differences between groups. "
06/01/2011 - "Globularia alypum aqueous extract decreases hypertriglyceridemia and ameliorates oxidative status of the muscle, kidney, and heart in rats fed a high-fructose diet."
01/01/2015 - "In the present study, a high-fructose diet (HFrD) fed rat model of hypertriglyceridemia was employed to further delineate the underlying mechanism by which NDGA exerts its anti-hypertriglyceridemic action. "
01/01/2013 - "In the study of hypertriglyceridemia induced by fructose, AEBO in doses of 400 mg/kg and 800 mg/kg reduced TG levels by 48.2% and 48.7%, respectively. "
11/01/1982 - "Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat."

10/01/2019 - "A selective PPARα modulator, Pemafibrate, effectively improved hypertriglyceridemia without major adverse events in real practice, with half dose once-daily administration. "
07/15/2021 - "Conclusion Pemafibrate treatment may be safe and effective for MAFLD patients with hypertriglyceridemia."
10/01/2023 - "Pemafibrate improved diastolic function in patients with T2D and hypertriglyceridemia, suggesting that PPARα activation by pemafibrate prevents the development of DCM at an early stage."
10/01/2019 - "Half Dose Once-Daily Pemafibrate Effectively Improved Hypertriglyceridemia in Real Practice."
07/01/2023 - "The aims of this study were to evaluate the efficacy and safety of pemafibrate in hypertriglyceridemia patients under clinical settings. "

06/01/1998 - "Hypertriglyceridemia has also been associated with PI therapies, and is apparent even in patients experiencing good results from antiretroviral therapy. "
07/29/2014 - "These findings indicate that targeted PCSK9-based therapies may also be effective in the management of postprandial hypertriglyceridemia."
03/01/1997 - "EPO therapy led to a mild improvement in CRF hypertriglyceridemia but failed to improve VLDL-R expression. "
07/01/2022 - "Our objectives in this review are to summarize the key findings of the REDUCE-IT trial and its subsequent analyses as well as to call for the reevaluation and expansion of current guidelines to incorporate IPE as a therapy for patients at elevated cardiovascular risk with mild or moderate hypertriglyceridemia."
01/01/2022 - "Future trials of risk-reduction therapies in hypertriglyceridemia could use CAC >100 to enroll a high-risk study sample, with implications for a larger target population."

06/01/2023 - "Pregnancy-induced severe hypertriglyceridemia effectively treated with therapeutic plasmapheresis."
10/01/2019 - "In our opinion, plasmapheresis appears to be safe and effective in reducing hypertriglyceridemia. "
05/01/2021 - "The results of this study recommend the use of plasmapheresis as a better alternative in preventing recurrent AP in Chinese patients with severe hypertriglyceridemia."
05/01/2021 - "The present study designed to compare the effect of plasmapheresis (PPH) versus standard treatment (STD) in preventing recurrent AP in Chinese patients with severe hypertriglyceridemia. "
07/01/2022 - "Double Filtration Plasmapheresis (DFPP) in Severe Hypertriglyceridemia Patients - a Pilot Study."

01/01/2022 - "Therapeutic plasma exchange was performed in 4 stages to treat the hypertriglyceridemia. "
01/01/2019 - "Extreme hypertriglyceridemia is rare (0.014%); and during pregnancy, it may require plasma exchange."
12/01/2017 - "Role of therapeutic plasma exchange in the treatment of severe hypertriglyceridemia: an experience."
09/01/2013 - "[Treatment of hypertriglyceridemia: plasma exchange]."
12/01/2009 - "Therapeutic plasma exchange in patients with severe hypertriglyceridemia: a multicenter study."

01/01/2022 - "This non-bound VLDL fraction increases in hypertriglyceridemia and in type-2 diabetes but decreases upon diabetes treatment that restores the glycemic control. "
01/01/2022 - "Hypertriglyceridemia was associated with poor glycemic control and smoking. "
08/01/2022 - "This study highlighted high-risk categories for NAFLD in diabetes, like young, obese, hypertriglyceridemia, poor glycemic control, etc. This information will help health care providers in prioritizing screening among high-risk diabetes population."
08/30/2019 - "Severe hypertriglyceridemia in a subject with disturbed life style and poor glycemic control without recurrence of acute pancreatitis: a case report."
04/01/2005 - "Whereas hypertriglyceridemia [OR: 2.39; 95% CI (1.42-4.03)] and hypertension [OR: 1.65; 95% CI (1.13-2.41)] were significantly associated with poor glycemic control according to FPG. "

09/01/2017 - "Dietary restriction of fat remains the mainstay of management in primary hypertriglyceridemia. "
09/01/2013 - "Dietary modification, increased physical activity, and weight management are the cornerstones of initial management for mild hypertriglyceridemia, which is a contributor to cardiovascular risk. "
02/15/2008 - "Managing hypertriglyceridemia with diet modifications."
12/01/2001 - "These results indicate that DG oil may be useful as an adjunct to the standard diet therapy of fat restriction in the management of diabetics with hypertriglyceridemia."
07/01/2011 - "Treatment for severe hypertriglyceridemia is often 3-fold, including lifestyle changes, diet modification, and pharmacotherapy. "