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Dideoxynucleosides

Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Also Known As:
ddNus; 2',3' Dideoxynucleosides; 2',3'-Dideoxynucleosides; Dideoxyribonucleosides
Networked: 27 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. McArthur, Justin C: 2 articles (06/2003 - 02/2002)
2. De Clercq, Erik: 1 article (07/2015)
3. Marquie-Beck, J A: 1 article (10/2008)
4. Gibson, S A: 1 article (10/2008)
5. Letendre, S L: 1 article (10/2008)
6. Hung, C F: 1 article (10/2008)
7. Vaida, F: 1 article (10/2008)
8. Lonergan, J T: 1 article (10/2008)
9. Ellis, R J: 1 article (10/2008)
10. Lactic Acidosis International Study Group: 1 article (11/2007)

Related Diseases

1. Infection
2. Peripheral Nervous System Diseases (PNS Diseases)
3. Acquired Immunodeficiency Syndrome (AIDS)
4. HIV Infections (HIV Infection)
5. Lactic Acidosis

Related Drugs and Biologics

1. Zidovudine (Retrovir)
2. Didanosine (Videx)
3. Zalcitabine (Hivid)
4. Stavudine (Zerit)
5. Mitochondrial DNA (mtDNA)
6. Anti-HIV Agents (AIDS Drugs)
7. Lamivudine (3TC)
8. Reverse Transcriptase Inhibitors
9. Interferon-alpha (Interferon Alfa)
10. Dextran Sulfate

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)