Sternocostoclavicular Hyperostosis

A rare, benign rheumatologic disorder or syndrome characterized by hyperostosis and soft tissue ossification between the clavicles and the anterior part of the upper ribs. It is often associated with the dermatologic disorder palmoplantar pustulosis, particularly in Japan. Careful diagnosis is required to distinguish it from psoriatic arthritis, OSTEITIS DEFORMANS, and other diseases. Spondylitis of pustulosis palmaris et plantaris is one of the possible causes; also, evidence suggests one origin may be bone infection. Bone imaging is especially useful for diagnosis. It was originally described by Sonozaki in 1974.

Also Known As:

Networked: 14 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteoporosis
3.	Hyperostosis
4.	Focal Infection
5.	Chest Pain (Chest Pains)

Experts

1.	Appelman-Dijkstra, Natasha M: 1 article (01/2021)
2.	Cañete, Ana Navas: 1 article (01/2021)
3.	Leerling, Anne T: 1 article (01/2021)
4.	Ramautar, Ashna I E: 1 article (01/2021)
5.	Winter, Elizabeth M: 1 article (01/2021)
6.	Horiuchi, Kazutaka: 1 article (09/2019)
7.	Komoda, Satsuki: 1 article (09/2019)
8.	Nakata, Syunsuke: 1 article (09/2019)
9.	Yuasa, Takeshi: 1 article (09/2019)
10.	Akimoto, Tetsu: 1 article (01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sternocostoclavicular Hyperostosis:

1.	Ibandronic Acid (Boniva)FDA Link 01/01/2006 - "Rapid pain relief and remission of sternocostoclavicular hyperostosis after intravenous ibandronate therapy." 09/01/2007 - "Lower dose, less intense dosing regimens of ibandronate relieve bone pain in non-malignant conditions: i.v. ibandronate (2 mg every 3 months with or without an initial 4 mg injection) provides pain relief for patients with corticosteroid-induced osteoporosis, localised transient osteoporosis (bone marrow oedema) and sternocostoclavicular hyperostosis. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/01/2008 - "Its use in corticosteroid-induced osteoporosis, Paget's disease and uncommon benign bone conditions such as localised transient osteoporosis (or bone marrow oedema syndrome) and sternocostoclavicular hyperostosis has also been explored. " 09/01/2007 - "Lower dose, less intense dosing regimens of ibandronate relieve bone pain in non-malignant conditions: i.v. ibandronate (2 mg every 3 months with or without an initial 4 mg injection) provides pain relief for patients with corticosteroid-induced osteoporosis, localised transient osteoporosis (bone marrow oedema) and sternocostoclavicular hyperostosis. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/1986 - "Pustulosis palmaris and plantaris, commonly associated with sternocostoclavicular hyperostosis, diminished after antibiotic therapy, as did the chest pain in most patients. " 08/01/1986 - "The similarities between age and sex distribution, and the responses to antibiotics of the patients with sternocostoclavicular hyperostosis and those with pustulosis suggest that these disorders have a common etiology, and that the pustulosis may represent "bacterid reaction", and the hyperostosis may also be a manifestation of a systemic reaction to a focal infection." 01/01/1986 - "The similarities between the age and sex distributions and the responses to antibiotics of the patients with sternocostoclavicular hyperostosis and those with pustulosis suggest that these disorders have a common etiology, and that the pustulosis may be a so-called bacterid reaction and the hyperostosis, a manifestation of a systemic reaction to a focal infection." 08/01/1986 - "Pustulosis palmaris et plantaris, commonly associated with sternocostoclavicular hyperostosis, diminished after antibiotic therapy as did the chest pain in most cases. "
4.	HLA-B27 Antigen (HLA B27 Antigen)IBA 12/03/1988 - "Although patients with sternocostoclavicular hyperostosis usually lack the tissue type antigen HLA-B27, there are grounds for suspicion that the disease is related to the group of seronegative spondylo-arthritides."
5.	Technetium Tc 99m MedronateIBA 06/01/1986 - "Eleven patients with PPP who were suspected to have sternocostoclavicular hyperostosis were studied with Tc-99m MDP whole body bone imaging. "
6.	Radioisotopes (Radionuclides)IBA 05/01/1986 - "A radionuclide and radiographic diagnosis of sternocostoclavicular hyperostosis."
7.	Proteins (Proteins, Gene)FDA Link 03/01/1986 - "These conditions include multiple myeloma, plasma cell granuloma, sternocostoclavicular hyperostosis, the POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes), and chronic symmetric plasma cell osteomyelitis of childhood. "
8.	Contrast MediaIBA 01/01/2017 - "Such characteristic structural abnormalities and our failure to identify the left subclavian vein with contrast material despite the abundant dilated collaterals in the left shoulder area encouraged us to diagnose our patient with sternocostoclavicular hyperostosis (SCCH) complicated by central vein obstruction. "
9.	Pamidronate (Aredia)FDA LinkGeneric 01/01/2021 - "Sternocostoclavicular Hyperostosis: Positive Clinical and Radiological Response on Pamidronate."

Therapies and Procedures

1.	Therapeutics 08/12/1988 - "[Irradiation as therapy in painful sternocostoclavicular hyperostosis]." 01/01/2006 - "Rapid pain relief and remission of sternocostoclavicular hyperostosis after intravenous ibandronate therapy." 01/01/1986 - "Pustulosis palmaris and plantaris, commonly associated with sternocostoclavicular hyperostosis, diminished after antibiotic therapy, as did the chest pain in most patients. " 08/01/1986 - "Pustulosis palmaris et plantaris, commonly associated with sternocostoclavicular hyperostosis, diminished after antibiotic therapy as did the chest pain in most cases. "
2.	Aftercare (After-Treatment) 03/01/1993 - "Both the local skin condition and the locomotory system improved after treatment, but sternocostoclavicular hyperostosis persisted. "
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 09/01/2019 - "[Coronary Artery Bypass Grafting complicated with sternocostoclavicular hyperostosis;Report of a Case]."