Tocolytic Agents (Tocolytics)

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.

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Networked: 655 relevant articles (37 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lamont, Ronald F: 7 articles (09/2016 - 01/2003)
2.	Haas, David M: 7 articles (11/2015 - 03/2009)
3.	Crowther, Caroline A: 6 articles (01/2017 - 01/2009)
4.	Chauhan, Suneet P: 5 articles (12/2020 - 09/2005)
5.	Morrison, John C: 5 articles (03/2015 - 02/2007)
6.	Nassar, Anwar H: 5 articles (03/2012 - 10/2006)
7.	Usta, Ihab M: 5 articles (03/2012 - 10/2006)
8.	Mittendorf, Robert: 5 articles (01/2011 - 05/2002)
9.	Pryde, Peter G: 5 articles (01/2011 - 05/2002)
10.	Mittendorf, R: 5 articles (01/2006 - 01/2000)

Related Diseases

1.	Premature Obstetric Labor (Premature Labor) 05/01/2014 - "Since there is no FDA approved tocolytic to treat preterm labor, clinicians should use the tocolytic that has afforded them the best results with the least maternal/neonatal side effects." 01/01/2018 - "In preterm labor with cervical dilatation, the efficacy of tocolytics was proven for prolonging pregnancy. " 01/01/2015 - "Term birth rate in pregnant women treated for preterm labor is significantly smaller compared to the general population, which may indicate low efficacy of tocolytic drugs. " 07/01/1999 - "The objective was to perform a systematic review of prospective randomized trials evaluating the efficacy of oral tocolytics in the prevention of recurrent preterm labor and its associated complications. " 01/01/2018 - "However, in threatened preterm labor, the efficacy of tocolytics has not yet been well studied. "
2.	Premature Birth (Birth, Premature) 10/01/2022 - "Combinations of tocolytics are probably effective in delaying preterm birth by 48 hours (RR 1.17, 95% CI 1.07 to 1.27; moderate-certainty evidence), and 7 days (RR 1.19, 95% CI 1.05 to 1.34; moderate-certainty evidence). " 12/01/1999 - "Once the uterus is quiescent and intravenous tocolytics are stopped, prolonged use of tocolytics has not been shown to be effective in preventing preterm birth. " 06/08/2023 - "In this study, we probed the tocolytic and therapeutic potential of these small molecules using myometrial cells and tissues obtained from patients receiving cesarean deliveries, as well as a mouse model of PL resulting in preterm birth. " 01/01/2023 - "In this study, we probed the tocolytic potential of these compounds using human myometrial samples and a mouse model of preterm birth. " 10/01/2022 - "We included all randomised controlled trials assessing effectiveness or adverse effects of tocolytic drugs for delaying preterm birth. "
3.	Rupture 10/11/2023 - "Overall, 596 of 803 pregnant individuals (73.4%) received tocolytics after preterm prelabor rupture of membranes. " 10/11/2023 - "The administration of tocolytics after preterm prelabor rupture of membranes remains a controversial practice. " 06/06/2023 - "Demographic variables (maternal age, race/ethnicity, and prior preterm delivery) and obstetrical variables (cervical dilation, effacement, membrane rupture, and tocolytic administration) were evaluated against the primary outcome of ACS administration. " 02/27/2014 - "Tocolytics for preterm premature rupture of membranes." 10/05/2011 - "Tocolytics for preterm premature rupture of membranes."
4.	Pain (Aches) 09/01/2021 - "Secondary outcomes included mean time from insertion to delivery, tachysystole, operative delivery for non-reassuring fetal status (NRFS), tocolytics, fetal outcomes, pain information, and subject satisfaction. " 03/01/2014 - "Women with successful ECV tolerated side effects of the intervention better than after unsuccessful ECV (pain, tocolytics, mental and physical state, for all p < 0.001). " 07/01/2009 - "The pain was not relieved by the application of tocolytics or mild analgesics. " 11/01/2007 - "The pain was not relieved by the administration of tocolytics or mild analgesics. " 10/06/2022 - "Managing pain during labor requires understanding the tocolytic properties of analgesics and their advantages in preventing the consequences of pain."
5.	Birth Weight (Birth Weights) 10/01/2022 - "Combinations of tocolytics possibly result in fewer neonates with birthweight less than 2500 g (RR 0.74, 95% CI 0.59 to 0.93; low-certainty evidence). " 04/01/2001 - "Groups were similar in selected demographics, tocolytic exposure, gestational age at delivery, modes of delivery, and mean birth weights. " 02/01/2001 - "Tocolytic effectiveness was also similar in terms of mean [SD] gestational age at delivery (35.8 [3.9] weeks vs 35.5 [4.1] weeks) and mean [SD] birthweight (2,491 [813] g versus 2,461 [831] g). " 06/01/1995 - "This retrospective analysis suggests that tocolytic intervention in cases of symptomatic preterm previa may be associated with clinically significant prolongation of pregnancy and increased birth weight. " 05/01/1991 - "In addition to the well-known negative influence of birth weight less than 1000 g and gestational age of less than 28 weeks, such parameters as antenatal pre-pathological CTG findings, haemorrhages at the time of hospitalisation, and ineffectuousness of tocolytic drugs, were associated with a reduced survival rate. "

Related Drugs and Biologics

1.	Nifedipine (Adalat)
2.	Progesterone
3.	Ritodrine (Yutopar)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Terbutaline (Brethaire)
6.	Calcium Channel Blockers (Blockers, Calcium Channel)
7.	Adrenergic beta-Agonists (beta-Adrenergic Agonists)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Magnesium
10.	atosiban

Related Therapies and Procedures

1.	Therapeutics
2.	Bed Rest (Bedrest)
3.	Cervical Cerclage
4.	Tocolysis
5.	Pessaries